关键词：
pharmacokinetics
multicompartmental models
dynamic contrast enhancement MRI
Crohn's disease assessment
摘要：
Post-contrastographic techniques represent an innovative method to identify pathologies out of anomalous perfusion of specific drugs (contrast agent) in ill body regions. In this framework, pharmacokinetics provides general models to describe the spatio-temporal distribution of drugs within the body: Simple model relies on the concept of compartment, that is, a body region with uniform properties. So, whole body can be thought of as made up of different compartments, interacting with each other by mass flows;this scheme reminds us of the typical sketch of a chemical process, whose active elements are tanks exchanging mass flows with each *** this framework, chemical engineering fundamentals (transport phenomena and chemical reaction engineering) provide the basic tools to represent the dynamic evolution of biological systems, once they can be sketched in terms of interacting compartments. The quantitative analysis, thus, is based on physically representative models, whose parameters describe physiological *** this work, we present a physiologically based pharmacokinetics model based on a joint, multiscale representation of body seen at global (systemic compartment) and local (region of interest compartment) scales: This model is able to face different limits of benchmark physiologically based pharmacokinetics models (Tofts, Brix, and Patlak), providing meaningful and quantitative model parameters, descriptive of contrast-enhanced physiological key properties. We apply the model to the analysis of dynamic magnetic resonance imaging with a contrast agent perfusion in Crohn's disease. All in all, we are going to demonstrate the method that can discriminate among ill and sane tissues, whereas the systemic parameters remain substantially *** model complies very well with clinical data, assessing the vascularization degree through characteristic properties (permeation characteristic time), and the spatial analysis assesses the vascular distributio
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详细信息
中文科技期刊
