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关键词： 甘油三醋酸酯   有机合成   催化剂   合成工艺   酯化反应   工艺条件  

关键词： 有机合成   绿色合成   有机合成方法   原料   催化剂   溶剂   环境污染  

摘要： 绿色有机合成是指采用无毒、无害的原料,催化剂和溶剂,选择具有高选择性、高转化率,不生产或少生产对环境有害的副产品合成,其目的是通过新的合成方法,开发制备单位产品产污系数最低,资源和能源消耗最少的先进合成方法和技术。

关键词： “树脂-捕获-释放”技术   有机合成   功能化聚合物   清除剂   液相合成物  

摘要： ”树脂 -捕获 -释放”技术使用功能化聚合物清除剂选择性地吸附目标产物 ,液相组合合成小分子化合物库 .这一技术结合了固相和液相的优点 ,操作简便、快捷 ,反应容易控制 ,产物易分离 ,且产率高 ,纯度好 .

关键词： 有机合成   有机化学  

ISBN: (纸本)7536936893

摘要： 该书介绍了一整套设计有机合成的方法，包括合成子概念的运用、用切断法对目标分子进行分析、推导合成所需要的原料、各种合成路线的对比以及设计合成线路时所运用的战略和战术等。

关键词： 精细化工-有机合成-高等学校-教学参考资料  

摘要： 本书针对精细有机合成的理论基础、精细有机合成的工艺学基础、氢化与还原等理论，提供了内容精要、练习题并给出答案。

关键词： Peptides and proteins   Organic reactions   Catalysts   Solvents   Catalysis  

摘要： The development of cascade conversions (i.e. combined (catalytic) reactions without intermediate recovery steps as taking place in living cells) is considered as one of the important future directions for carrying out sustainable organic syntheses with inherently safer designs. It will drastically reduce operating time and costs as well as consumption of auxiliary chemicals and use of energy. Production of waste for multistep syntheses might ultimately reach the level of well below 1 kg per kg of product. The concept of cascade conversions is demonstrated by a representative selection of illustrative, mostly catalytic, examples on laboratory as well as on pilot or industrial scale and discussed within the strategic context of new synthesis methodology as required by present developments in life sciences industries. Full exploitation of such multistep syntheses and catalysis will require the development of novel, mutually compatible, organic and biosynthetic methods and procedures. Eventually a full integration of organic synthesis and biosynthesis can be envisaged. Syntheses requiring a smaller range of reaction parameters and reagents but a more intricate array of efficient catalysts might be expected. Integration with in situ product separation techniques will become mandatory, preferably by continuous processing.

ISBN: (纸本)7561818297

关键词： Pyridine  

摘要： A variety of pyrido[2,1-b]benzothiazole derivatives could be prepared by reaction of 2-cyanomethylbenzothiazole, formaldehyde, and various active methylene reagents. Also some polyfunctionally-substituted pyridines were prepared by reaction of 2-cyanomethylbenzothiazole, formaldehyde, and an a-functionally substituted acrylonitrile.

关键词： Laccases   Phenol Oxidases   oxyfunctionalisation   hydroxylated products   biocatalysts  

摘要： This is a review of recent progress in developing biocatalytic reactions. involving two major groups of phenol oxidases, viz., laccases (benzenediol: oxygen oxidoreductase E.C. 1.***.13.2) and polyphenol oxidases (phenol: oxygen oxidoreductase, E.C. 1.***.18.1, also known as tyrosinase). Oxidases catalyse reactions involving direct activation of oxygen, and within this group, the multi-copper oxidases catalyse the four-electron reduction of oxygen to water with the concomitant one-electron oxidation of a substrate. Such reactions, applied in biocatalytic systems, provide effective methods to achieve oxyfunctionalisation, (particularly asymmetric oxyfunctionalisation reactions) and routes to controlled and predictable formation of oxy- and hydroxylated products, and polymers. The review includes discussion of the characteristics of these enzymes which are of relevance to their application as biocatalysts.

关键词： batch reactor   intensified by microwave   REACTIVE GASES   MICROWAVE   ON-LINE MONITORS   single-mode   Organic Synthesis   Inert   Reaction Time   Scalability   Cycloaddition Reaction   PARALLEL PROCESSING (COMPUTERS)   Ships  

摘要： The direct scalability of microwave-assisted organic synthesis (MAOS) in a prototype laboratory-scale multimode microwave batch reactor is investigated. Several different organic reactions have been scaled-up typically from 1 mmol to 100 mmol scale. The transformations include multicomponent chemistries (Biginelli dihydropyrimidine and Kindler thioamide synthesis), transition metal-catalyzed carbon-carbon cross-coupling protocols (Heck and Negishi reactions), solid-phase organic synthesis, and Diels-Alder cycloaddition reactions using gaseous reagents in prepressurized reaction vessels. A range of different solvents (high and low microwave absorbing), Pd catalysts (homogeneous and heterogeneous), and varying reaction times and temperatures have been explored in these investigations. In all cases, it was possible to achieve similar isolated product yields on going from a small scale (ca. 5 mL processing volume) to a larger scale (max 500 mL volume) without changing the previously optimized reaction conditions (direct scalability). The prototype, benchtop multimode microwave reactor used in the present study allows parallel processing in either quartz or PTFE-TFM vessels with maximum operating limits of 300 C and 80 bar of pressure. The system features magnetic stirring in all vessels, complete on-line monitoring of temperature, pressure and microwave power, and the ability to maintain inert or reactive gas atmosphere.