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关键词： Proteins  

摘要： The dysbiosis of gut microbiota is closely related to the occurrence and development of inflammatory bowel disease (IBD). The manipulation of intestinal flora through prebiotics or probiotics is expected to induce and maintain the remission of IBD symptoms. 6-week-old C57BL/J mice were daily gavaged with fructooligosaccharides (FOS) or the synbiotic two weeks before the administration of dextran sulfate sodium (DSS). The supplementation of FOS or synbiotic could significantly ameliorate the body weight loss and colon histological damage in DSS-induced acute colitis mice. The altered composition of gut microbiota in acute colitis mice was reversed by FOS or Synbiotic supplementation, with a characteristic of decreased abundance of Mucispirillum. Both FOS and synbiotic mitigated DSS-induced loss of mucus protein (MUC2) and epithelium tight junction proteins (ZO-1, Occluding, Claudin1) in colon mucosa. The expression of pro-inflammatory cytokines (IL-6 and TNF-alpha) was decreased by FOS or synbiotic treatment, while the expression of Tbx21 and IL-10 was increased. The results suggested that the modulation of gut microbiota by FOS or synbiotic supplementation could decrease the inflammation potential of colonized commensals, which prevented the impairment of the intestinal barrier and induced a regulation of immune response in DSS-induced acute colitis mice.

关键词： 影像学技术   法医病理学   应用价值  

摘要： 影像学技术是当前最常用的检查技术之一,随着技术水平的不断提高,其在法医病理学当中也能够发挥出较高的应用价值。在很多法医病理学常见问题当中,如个体识别、死因分析、损伤时间判断、致伤方式判断、身体异物识别等方面,都能得到较好的应用。

关键词： pathological diagnosis   lesions   special dyeing  

摘要： Toxicity pathology assessment is one of the most important link in preclinical safety evaluation of drugs, to determine the nature of the lesion and the toxic target organs, and special staining is simple, the result is reliable, can assist the pathological diagnosis, the correct application of a variety of special staining method can identify certain chemicals within the organization, in order to verify the existence of various structures, which can play a decisive role in the diagnosis of pathological changes.

关键词： MOOC平台   病理学   教学设计   混合式  

摘要： 线上线下混合教学已是先进的新型教学模式。“病理学”是衔接医学基础与临床的重要桥梁课程。目前,高职学生整体素质弱,教学设计混乱。基于MOOC平台病理学混合教学模式的设计,由平台自主学习、课堂教学和实践运用三部分组成的,以肝硬化为例进行的混合教学设计,利于提高学生学习主动性、学习效果,利于角色的转变,充分发挥学生的个性化学习潜能,培养学生的自主学习和合作能力,提高教学质量和效率。

关键词： Stroke   Carotid web  

关键词： 子宫内膜息肉   临床病理学特征   鉴别诊断   临床效果  

摘要： 随着生活节奏的加快,女性面临着越来越大的压力,其患病的可能性随之升高,临床上子宫内膜息肉的患者随之增多,对该类患者的发病原因进行分析,对检查方式和治疗方案进行研究,这是临床医学工作者重点关注的方向和课题。方法:对我院在2020年1月至2020年12月入院检查并被确诊为子宫内膜息肉的53例患者资料进行回顾和分析。结果:通过分析发现,28例患者的临床表现以阴道出血为主,19例患者的临床表现以不规则阴道出血为主,4例患者的临床表现以绝经后再发生阴道出血为主,2例患者月经无明显改变;对上述53例患者中的18例患者行全子宫切除术,对其余患者采用保守治疗。结论:子宫内膜息肉是发生在女性子宫内膜中的一种病变,主要由于患者的内膜的异常增生而出现的息肉样改变所导致,有学者指出,子宫内膜息肉与炎症、内分泌紊乱和雌激素水平过高等因素有关。临床上对子宫内膜息肉是通过超声检查来进行确诊的。由于子宫内膜息肉发病机制复杂,诱因较多,发病初期又无典型的临床症状,常被误诊或漏诊。这要求医护人员应根据的患者的临床表现,结合病理学特征,通过超声方式对其进行临床鉴别,根据患者的实际情况采取不同的方案进行治疗,提高患者的预后质量和生活质量。

关键词： Stroke   Middle cerebral artery   Dihydrocapsaicin   Antioxidant   Anti-apoptotic  

摘要： Aims: Ischemic stroke occurs when there is a sudden blockage of cerebral blood flow. This condition is a major cause of mortality, especially in low-income countries, and its incidence is dramatically increasing. Therapeutic strategies against stroke are therefore required. The present study explored the effects of dihydrocapsaicin on neuronal loss, brain infarct volume, and antioxidants in a rat model of permanent occlusion of the right middle cerebral artery (***). Main methods: Male Wistar rats received dihydrocapsaicin intraperitoneally for 7 days after permanent occlusion of their right middle cerebral artery (***). Then, the brain infarct volume, neuronal density, and antioxidant and anti-apoptotic activities in the cortex and hippocampus were determined at the end of the study. Key finding: Dihydrocapsaicin treatment was found to significantly improve neuronal density, decrease infarct volume, reduce MDA elevation, improve CAT and SOD activities, decrease the density ratio of Bax and caspase-3, and increase the density ratio of Bcl-XL to beta-actin in the cerebral cortex and hippocampus. Significance: The present study suggests that dihydrocapsaicin effectively mitigates cerebral ischemia-induced pathological changes in vivo, partly via antioxidant and anti-apoptotic pathways.

关键词： 宫颈薄层液基细胞学检测   HPV检测   联合检测   宫颈组织病理学  

摘要： 分析宫颈薄层液基细胞学、HPV联合检测与宫颈组织病理学的关系。方法:研究时间:2020年2月-2021年2月。本研究的研究对象为95例需要宫颈癌筛查的患者。进行薄层液基宫颈细胞学检查和HPV检测。结果:宫颈薄层液基细胞学检测阳性率为18.94%(18/95),宫颈薄层液基细胞学联合HPV检测阳性率为32.52% (31/95),TCT联合HPV检测符合率为85.71%(18/21)。宫颈薄层液基细胞学、HPV联合检测与宫颈组织病理学诊断符合率较高(P<0.05),差异有统计学意义。结论:在宫颈癌筛查中,宫颈薄层液基细胞学联合HPV检测,更有利于宫颈癌的早期检出,为患者早期干预提供依据。