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关键词： 翻转课堂   医学教学   问卷调查   访谈  

摘要： 本文根据收回的问卷还有访谈结果,分析了翻转课堂在生化课堂中的应用效果,指出了应用过程中出现的一些学生们效率不高,成绩也没有明显提高的现象,提出了相应的改进策略,找出适合南通大学杏林学院医学生的教学模式并为以后的教学改革提供指导。

关键词： 生物化学   课程思政   元素  

摘要： "生物化学"是食品科学与工程类的专业基础课程,"生物化学"知识体系中蕴含着丰富的思想政治教育元素。因此,为提升专业课程的课程思政教育水平、全方位育人,本课程教学团队充分挖掘《生物化学》内容的思政教育元素和探索相应的实施策略,将创新意识,坚持不懈、刻苦奋斗意识,文化自信,伦理道德,敬仰英雄安全意识等思政教育元素有机融入"生物化学"课堂教学中,有机结合专业知识传授与思想政治教学从而提高专业课程教学和思想道德教学的质量,最终达到"课程思政"育人的教学目标。

关键词： 大健康   医药生物化学   教学质量  

摘要： 在大健康产业兴起的背景下,为适应医药高职院校人才培养目标,符合医药专业岗位需求,针对学生情况及生物化学课程内容特点,从培养学生的学习兴趣、医药专业岗位需求、多元化教学方法等方面进行了探讨,为找到提高教学质量的有效路径提供参考。

关键词： Acetylphenol   alpha-Glucosidase   Diabetes   Structure-activity relationship   Hyperglycemic activity  

摘要： The discovery of novel alpha-glucosidase inhibitors and anti-diabetic candidates from natural or natural-derived products represents an attractive therapeutic option. Here, a collection of acetylphenol analogues derived from paeonol and acetophenone were synthesized and evaluated for their alpha-glucosidase inhibitory activity. Most of derivatives, such as 9a-9e, 9i, 9m-9n and 11d-1e, (IC50 = 0.57 +/- 0.01 mu M to 8.45 +/- 0.57 mu M), exhibited higher inhibitory activity than the parent natural products and were by far more potent than the antidiabetic drug acarbose (IC50 = 57.01 +/- 0.03 mu M). Among these, 9e and 11d showed the most potent activity in a noncompetitive manner. The binding processes between the two most potent compounds and alpha-glucosidase were spontaneous. Hydrophobic interactions were the main forces for the formation and stabilization of the enzyme acetylphenol scaffold inhibitor complex, and induced the topography image changes and aggregation of alpha glucosidase. In addition, everted intestinal sleeves in vitro and the maltose loading test in vivo further demonstrated the alpha-glucosidase inhibition of the two compounds, and our findings proved that they have significant postprandial hypoglycemic effects.

关键词： Biochemical parameters   H. nana   Histopathological   Mice   Mirazid  

摘要： Hymenolepiasis is a common parasitic infection of children and considered an opportunistic disease with a life-threatening effect among immunocompromised patients through cysticercoid dissemination. Mirazid (Commiphora molmol) is new phytotherapy for hymenolepiasis. So, the present study aimed to evaluate the effects of Mirazid treatment comparing to Praziquantel (PZQ) (standard treatment) among immunocompetent and immunocompromised infected albino mice through biochemical and histopathological parameters. A total of 60 clean male albino mice (immunocompetent group) were divided into equal five groups which were infected and treated with Mirazid beside PZQ. Another 72 infected immunocompromised animals were divided into equal six groups and were also treated with Mirazid and PZQ. Liver and kidney functions were estimated as well as histopathological examination of intestine and liver. Levels of AST in the serum of infected mice treated with Mirazid or PZQ recorded a highly significant increase compared to the normal control group. The percentage of increase was 83.30% and 36.60% respectively. While the infected group recorded a non-significant decrease in AST level and the percentage of decrease was − 7.4%. Immunocompetent groups showed a positive significant correlation with the control Mirazid or control PZQ groups recorded an increase in liver function enzymes (AST, Bilirubin, and GGT) (P < 0.001) comparing to the normal control group. In conclusion, Mirazid showed higher cure rates than PZQ, 95.45%, and 74.54% on the 15th and the 21st days, it reached 100% respectively associated with good improvement of histopathological changes in intestine and liver. © 2020, Indian Society for Parasitology.

关键词： 生物化学   新工科   课程思政   互联网+  

摘要： 国家发展对人才提出了越来越高的要求。“新工科”计划、“课程思政”建设等为教学改革等指明了方向,而新冠疫情的暴发迫使高校教师掌握和应用在线教学工具,在某种程度上促进了教育教学的改革。在后疫情时期,食品专业的生物化学课程的教学,应融合生物化学思政资源,充分利用“互联网+”资源,改进教学方式,优化课程体系,调动学生的主观能动性,培养学生的综合能力,体现课程知识传授和人文关怀融合的全方位育人,推进生物化学教学到达一个新阶段。

关键词： 生物化学   示范性实验   开放管理   教学改革  

摘要： 以本校生物制药专业大一下学期的本科生为对象,选择植物过氧化物酶的提取、活性测定及同工酶凝胶电泳分析作为示范性实验项目进行探索,在同行们积累的经验基础上,摸索出了一套"放""管"结合的综合性设计性实验教学模式,既发挥了学生的主动性和创造性,又保证了较好的实验教学效果。经在本校相近专业推广,反映良好,显示较好的推广示范潜力。

关键词： Enzyme kinetics   Principle of dimensionless transformation   Dimensionless substrate concentration   Dimensionless kinetic constant   Relative magnitude of kinetic constants   Dimensionless inactivation constant  

摘要： A novel general principle was proposed to transform enzyme kinetic equations into unified dimensionless forms. The principle consists of six steps. The principle was applied to ten complex biochemical reaction systems and their characteristics were mathematically analyzed. The approach has six merits.: (i) the number of parameters is reduced, (ii) the rate expressions and their progress curves become much simpler, easily understood and are analyzed globally by the newly defined dimensionless time, T, (iii) the relative magnitude of kinetic constants and of the maximum velocity involved in the rate equations are straightforwardly estimated by three type m values, (iv) mass balance and stoichiometric relationship of the dimensionless rate expressions are exactly the same format as of the actual rate expressions, (v) 2D or 3D plots of the unified dimensionless equations can be depicted without inputs of the actual experimental data of the variables and kinetic constants, and (vi) the newly defined dimensionless inactivation constant, Kiact, is useful to estimate the effect of the enzyme inactivation on the batch reactions. The principle is beneficial for the mathematical analyses of complex biochemical reactions involving two or more kinds of enzymes, for those involving two or more substrates or for those involving both.

关键词： 身心和谐发展   体育养生   生物化学   中国传统体育养生文化   融合研究   思想精髓   系统化   实践意义  

摘要： 现在体育养生文化由经历几千年历史考验流传至今的中国传统体育养生文化发展而来,对引导人们健康生活有着积极作用。故进一步把它的思想精髓融入到运动建康生物化学中,不仅对促进人身心和谐发展具有重要意义,而且对促进体育养生向系统化科学发展具有很高的理论价值和实践意义。

关键词： Photosynthesis  

摘要： Light, or visible radiation, serves as a source of energy for photosynthesis of plants and most algae. In addition, light and ultraviolet radiation (UV-A and UV-B) act as a biological signal, triggering several cellular processes that are mediated by photoreceptors. The aim of this study was to evaluate the physiological and biochemical responses of Osmundea pinnatifida driven by different radiations through putative photoreceptors. For this, O. pinnatifida was grown under different radiation treatments composed by high intensity of light emitted by a low pressure sodium lamp (SOX), aiming to saturate photosynthesis, which was supplemented by low intensities of visible (red, green and blue) and ultraviolet radiation (UV-A and UV-B), in order to activate photoreceptors. Growth rates, photosynthesis, antioxidant activity, polyphenols, soluble proteins, phycobiliproteins, mycosporine-like amino acids (MAAs) and carotenoids were evaluated during the experiment. Complementary UV-A radiation positively influenced growth rates after 15 days of experiment, although the presence of a peak of blue light in this treatment can also have contributed. UV-B radiation increased the concentration of zeaxanthin and chlorophyll a. The blue light caused the accumulation of chlorophyll a, violaxanthin, phycoerythrin and polyphenols on different days of the experiment. Phycoerythrin also increased under green and red light conditions. Our results showed that some compounds can be modulated by different radiation, and the involvement of photoreceptors is suggested. In red algae, photoreceptors sensitive to red, green and blue light have been identified, however little is known about UV photoreceptors. The presence of photoreceptors sensitive to UV radiation in O. pinnatifida is discussed.