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关键词： 混合式教学   学习分析   学习路径挖掘   教学改革  

摘要： 伴随线上线下相结合的混合式教学的广泛开展,线上教学平台积累形成数量可观、类型丰富的学习过程数据。应用学习分析技术对这些学习过程数据作出分析有望能获得更为精准的学情,可为教学改革提供科学依据。本研究通过收集并分析一门大学课程实施混合式教学后的学习过程数据,挖掘了学习该课程的大学生在网络平台上的整体学习路径,从学习风格和学业成绩两个方面挖掘形成了聚类学习路径。路径挖掘结果显示,混合式教学应精细化安排不同学习模块中的学习资源以提升资源访问率,需丰富学习资源类型以满足不同学习偏好,要提升学习资源的逻辑性和可视化程度以促进深度学习,还应借助小组研讨以促进同伴学习和替代式学习。

关键词： 翻转课堂   生物化学   教学改革   教学效果评估  

摘要： 阐述了生物化学课程基于翻转课堂模式下的教学改革思路,对课前资料准备、课堂教学、课后答疑解惑环节进行了有益探索,以河南科技大学农学专业学生为研究对象,开展生物化学翻转课堂模式教学改革,比较分析其教学效果。结果显示,翻转课堂可以激发学生学习兴趣,提高学习效率,增强自主获取知识的能力等,提出翻转课堂教学中亟待解决的关键问题及对策建议。

关键词： 生物化学   课程思政  

摘要： "课程思政"是新时代高校落实立德树人这一根本任务的重要途径。本文从总体要求、教学目标、教学内容、教学方法和考核方式5个维度出发,对"课程思政"视角下生物化学教学进行了初步探索和实践,并重点在教学内容维度介绍了如何挖掘和有机融合思政元素,有助于实现生物化学课程的隐性育人功能。

关键词： 中医院校   研究生   生物化学   课程教学  

摘要： 近年来随着中医药事业的发展,中医院校正逐步向运用现代科学技术阐释传统医学理论的方向转变。生物化学技术是推动中医药现代化强有力的工具,其相关理论依据和实验技术也更多地应用到中医药的实验研究中。为了进一步提高中医院校研究生生物化学课程的教学质量,进一步优化改革生物化学课程的教学模式,研究者对本校选修生物化学课程的77名研究生进行了问卷调查和分析。调查结果显示,选课学生大部分理论基础较强,实验基础薄弱,学习目的明确,各自有相关的学习方法,对于课程的进行有很多创新性的建议。通过问卷调查分析,了解到学生对于生物化学课程的掌握程度、学习动机、学习目的、学习方法以及对课程的建议,调查结果能够为授课教师提供很好的参考,为课程的改革提供依据。

关键词： 医学生物化学   教学改革   教学体系  

摘要： 扬州大学医学院已进行多年的留学生医学生物化学的课程建设,在教学过程中逐步摸索出一整套新的教学模式和教学体系,激发留学生的学习兴趣和主动性,提高理解和分析问题的能力。文章从课程体系、教学方式和考核细则等几方面进行探讨和总结,以期进一步提高教学质量及对教学改革起到积极的促进作用。

关键词： 生物化学实验   知识型人才   信息时代   实用型人才   科技和经济   人才需求   深化理解   综合国力  

摘要： 随着科技革命不断推进,全球科技水平不断提高,信息时代悄然而至。科技是信息时代的重要基石,故近些年各国竞争的实质是以科技和经济为基础的综合国力的竞争。生物化学涉及生物、食品、医学等诸多领域,与国家的科技水平密切相关。如今时代不断发展,社会对生物化学相关领域的人才需求呈现出由知识型人才向实用型人才转变的趋势,同时标准也有了相应提高。实验是生物化学中的一个重要组成部分,通过实验,学生可以验证、深化理解相关知识理论。

关键词： multifunctional protein   lectin properties   bioinsecticides   enzyme activity   insect gut  

摘要： Talisin is a storage protein from Talisia esculenta seeds that presents lectin-like and peptidase inhibitor properties. These characteristics suggest that talisin plays a role in the plant defense process, making it a multifunctional protein. This work aimed to investigate the effects of chronic intake of talisin on fifth instar larvae of Spodoptera frugiperda, considered the main insect pest of maize and the cause of substantial economic losses in several other crops. The chronic intake of talisin presented antinutritional effects on the larvae, reducing their weight and prolonging the total development time of the insects. In addition, talisin-fed larvae also showed a significant reduction in the activity of trypsin-like enzymes. Midgut histology analysis of talisin-fed larvae showed alterations in the intestinal epithelium and rupture of the peritrophic membrane, possibly causing an increase of aminopeptidase activity in the midgut lumen. Talisin also proved to be resistant to degradation by the digestive enzymes of S. frugiperda. The transcription profile of trypsin, chymotrypsin and aminopeptidase genes was also analyzed through qPCR technique. Talisin intake resulted in differential expression of at least two genes from each of these classes of enzymes. Molecular docking studies indicated a higher affinity of talisin for the less expressed enzymes.

关键词： Wound healing   Nanoemulsion   Lavandula angustifolia   Glycyrrhiza glabra   Rat  

摘要： Cutaneous wound healing is one of the public health interests. This study aimed to investigate the effects of nanoemulsion cream containing lavender essential oil and licorice extract on the healing of deep skin wound in a rat model. Eighty-five male Wistar rats were randomly divided into five groups including untreated defects as negative control and defects treated with vehicle ointment, lavender essential oil and licorice extract in emulsion and nanoemulsion forms, and phenytoin 1% as the positive control with an excisional wound on the dorsal neck of each rat. On days 2, 7 and 14 oxidative stress factors were evaluated in wound tissue homogenates. The expression of transforming growth factor-beta (TGF-beta), and type I and type III collagen genes were evaluated. Also, wound tissue samples were processed for Hematoxylin Sr Eosin and Masson-Trichrome staining. Nanoemulsion reduced the wound area more than other groups significantly. Real-time PCR data demonstrated that nanoemulsion and phenytoin groups have shown the best result in increasing TGF-beta 1, Type I and type III collagen genes expression compared to the other groups. Reduction in lipid peroxidation level and increasing in SOD and GPx activity was also significant in the nanoemulsion and phenytoin groups. The formation of granular tissue likewise the appearance of collagen in nanoemulsion and phenytoin groups were faster than the other groups. Nanoemulsion cream containing lavender essential oil and licorice extract exhibited a promising wound healing potential towards the excisional wound model in rats.

关键词： Iron   Membrane enzymes   Antioxidant system  

摘要： Iron is an essential element for human life. However, it is a pro-oxidant agent capable of reacting with hydrogen peroxide. An iron overload can cause cellular changes, such as damage to the plasma membrane leading to cell death. Effects of iron overload in cellular biochemical processes include modulating membrane enzymes, such as the Na, K-ATPase, impairing the ionic transport and inducing irreversible damage to cellular homeostasis. To avoid such damage, cells have an antioxidant system that acts in an integrated manner to prevent oxidative stress. In addition, the cells contain proteins responsible for iron transport and storage, preventing its reaction with other substances during absorption. Moreover, iron is associated with cellular events coordinated by iron-responsive proteins (IRPs) that regulate several cellular functions, including a process of cell death called ferroptosis. This review will address the biochemical aspects of iron overload at the cellular level and its effects on important cellular structures.