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关键词： 本科院校   医学生物化学   线上线下混合教学   微课  

摘要： 本科院校是培养人才的摇篮,学校开设医学生物化学课程,旨在为国家输送高素质复合型人才。为了提高教学质量,高校要转变传统的教学方式,将线上与线下教学有机结合,打造混合式教学模式,开发优质微课资源,给学生带来全新的体验。教师要转变传统的教学理念,对教学进行合理设计,为学生打造充满吸引力的课堂。本文首先介绍了医学生物学课堂教学与学习现状,然后详细介绍了基于微信公众平台的线上线下混合式教学模式建设和混合式教学模式下微课资源的开发策略。

关键词： 课程思政   生物化学与分子生物学   案例教学法  

摘要： 课程思政是当代高校教育的新理念,加强德育教育对提高医学生的综合素质尤为重要。生物化学与分子生物学是和医学密切相关的前沿学科,包含了丰富多元的“思政元素”,利于课程思政的开展。但此课程不仅知识点多且杂,更由于专业术语较生僻,加大了学习困难。在充分认识到此课程内容特点及思政意义后,对课程中所具有的"思政元素"进行了系统深入发掘、分类与整理,并融合传统教学特色和案例教学法的优势,加以合理的课程设计,将课程中思政教学元素的融合发展成为常态化、正常化。

关键词： 医学   生物化学   课程思政  

摘要： 为提高医学类专业人才培养质量,充分发掘课程的育人功能,我们以医学生物化学课程为载体、以立德树人为根本任务开展课程思政,通过线上线下混合式教学,将价值塑造、知识传授和能力培养三者有机融为一体,潜移默化中引导学生塑造正确的世界观、人生观、价值观,将生物化学打造成有高度、有深度、有温度的医学类专业“金课”。

关键词： 思政元素   生物化学   教学探讨  

摘要： 课程思政是立德树人和现代教师课程教育的必然要求。生物化学是生物学专业本科生的必修课程,将思政元素融入生物化学教学中,不仅能够提升学生的专业水平,还能深化生物化学教学探讨,让学生将实际生活与课本知识紧密结合,对生物化学专业课的课程思政进行了有益的探索。2016年12月,习近平总书记在全国高校思想政治工作会议上发表重要讲话,强调“把思想政治工作贯穿教育教学全过程,开创我国高等教育事业发展新局面”。党的“十八大”以来,党中央先后召开全国高校思想政治工作会议、全国教育大会,对于思政课建设多次讲过意见。习近平总书记对教育工作强调得最多,尤其是思政课建设是强调最多的。高等教育肩负着培养德智体美全面发展的社会主义事业建设者和接班人的重大任务,办好我国高校,办出世界一流大学,必须牢牢抓住全面提高人才培养能力这个核心点。由此可见,将思政元素融入专业课中是非常重要和必要的。在“互联网 ”时代,提高高校大学生思想政治教育,构建思政教育体系,是当前高校培养复合型人才的必要途径。

关键词： 实验教学改革   生物化学与分子生物学   传统教学法   “互联网+”混合式教学法  

摘要： 《生物化学与分子生物学》实验是一门重要的基础实验课程,在医学院校应用型人才培养方面发挥着至关重要的作用。新冠疫情下,高校实验教学遇到了新的挑战。该文采用对比研究法,在一年级本科实验教学过程中,探索传统教学法和“互联网+”混合式教学法的应用。实践证明:“互联网+”混合式教学法获得更高的学生喜爱度,学习效果更佳,同时还能更新教师知识结构,促进师生交流。“互联网+”混合式教学法适合在《生物化学与分子生物学》实验教学中推广应用。

关键词： 一流专业建设   生物化学   思政元素   立德树人  

摘要： “生物化学”是生物科学专业核心课程之一。针对青岛农业大学生物科学专业学生在德育提升、基本能力与创新能力提升、职业素养提升、职业发展能力等方面存在的突出问题,在一流专业建设背景下,以立德树人育人目标为统领,从对该课程的教学大纲修订、课程思政元素的挖掘、“以学生为中心”的教学方法改革、构建课程“学-思-知-行”四位一体的育人体系等方面,对“生物化学”课程的课程思政教学进行了思考和探索,以期为实现专业课程育人目标提供新思路和新方案。

关键词： 执业助理医师资格考试   通过率   生物化学  

摘要： 针对过去几年云南省职业院校毕业生执业助理医师资格考试通过率较低的现状,着重分析生物化学教学存在的突出问题,提出生物化学教师必须转变观念,使教学贴近临床、贴近执业助理医师资格考试,优化教学大纲,实施以学生为中心的多元化教学模式,改革生物化学考核评价体系,为提高职业院校执业助理医师资格考试通过率奠定坚实基础。

关键词： environmental engineering   kinetic parameters   microbial interaction   nitrifiers  

摘要： Is it possible to find trends between the parameters that define microbial growth to help us explain the vast microbial diversity? Through an extensive database of kinetic parameters of nitrifiers, we analyzed if the dominance of specific populations of nitrifiers could be predicted and explained. We concluded that, in general, higher growth yield (Y-XS) and ammonia affinity (a(NH3)(0)) and lower growth rate (mu(max)) are observed for ammonia-oxidizing archaea (AOA) than bacteria (AOB), which would explain their considered dominance in oligotrophic environments. However, comammox (CMX), with the maximum energy harvest per mole of ammonia, and some AOB, have higher a(NH3)(0) and lower mu(max) than some AOA. Although we were able to correlate the presence of specific terminal oxidases with observed oxygen affinities (a(O2)(0)) for nitrite-oxidizing bacteria (NOB), that correlation was not observed for AOB. Moreover, the presumed dominance of AOB over NOB in O-2-limiting environments is discussed. Additionally, lower statistical variance of a(O2)(0) values than for ammonia and nitrite affinities was observed, suggesting nitrogen limitation as a stronger selective pressure. Overall, specific growth strategies within nitrifying groups were not identified through the reported kinetic parameters, which might suggest that mostly, fundamental differences in biochemistry are responsible for underlying kinetic parameters.

关键词： aetiological evolution   characterisation methods   imported cases   Spain   tegumentary leishmaniasis  

摘要： Leishmaniasis is a transmissible disease caused by Leishmania protozoa. Spain is endemic for both visceral and cutaneous leishmaniasis, the autochthonous aetiological agent being Leishmania infantum. Around the world, the L. donovani complex is associated with visceral symptoms, while any species of the Leishmania or Viannia subgenera affecting human can produce tegumentary forms. In a context of growing numbers of imported cases, associated with globalisation, the aim of this study was to analyse the aetiological evolution of human tegumentary leishmaniasis in a region of Spain (Catalonia). Fifty-six Leishmania strains, isolated from 1981 to 2018, were analysed using MLEE, gene sequencing (hsp70, rpoIILS, fh and ITS2) and MALDI-TOF. The utility of these different analytical methods was compared. The results showed an increase in leishmaniasis over the two last decades, particularly imported cases, which represented 39% of all cases studied. Leishmania infantum, L. major, L. tropica, L. braziliensis, L. guyanensis and L. panamensis were identified. The combination of molecular and enzymatic methods allowed the identification of 29 different strain types (A to AC). Strain diversity was higher in L. (Viannia), whilst the different L. major types were relatable with geo-temporal data. Among the autochthonous cases, type C prevailed throughout the studied period (39%). Minor types generally appeared within a short time interval. While all the techniques provided identical identification at the species complex level, MALDI-TOF and rpoIILS or fh sequencing would be the most suitable identification tools for clinical practice, and the tandem hsp70-ITS2 could substitute MLEE in the epidemiological field.

关键词： male   medicinal plants   spermatozoa   testis   testosterone  

摘要： The oral administration of Tribulus terrestris and Lepidium meyenii extracts on reproductive, biochemical and body parameters was evaluated in rats. Thirty-six male Wistar rats weighting 210 +/- 18 g were divided into six experimental groups (n = 6). Each group received, daily for 28 days, different solutions: T. terrestris (100 mg/kg), L. meyenii (1 g/kg) and T. terrestris at doses of 75, 50 and 25 mg/kg combined with L. meyenii at doses of 0.25, 0.5 and 0.75 g/kg, respectively, and distilled water (control). T. terrestris increased (p < 0.05) the serum testosterone, regardless of dose. Combined use of the extracts increased (p < 0.05) the diameter of the epididymal duct and epididymis lumen. The combinations of T. terrestris (75 and 50 mg/kg) with L. meyenii increased (p < 0.05) the sperm concentration. There were no differences (p > 0.05) in the other semen characteristics;relative weight of organs;and serum levels of urea, creatinine, alanine and aspartate transaminase, gamma glutamyl transferase, cholesterol, triglycerides, glucose, follicle-stimulating hormone and luteinizing hormone. No histopathological changes were observed (p > 0.05). It is concluded that the association of T. terrestris and L. meyenii has positive effects on serum testosterone, sperm concentration and epididymal morphology, with no evidence of effects in the testis, liver, spleen and kidneys.