教学课程资源库 更多>>

关键词： 肾性贫血   适应性反应   机体细胞   医学奖   低氧诱导因子   HIF   信号通路   氧浓度  

摘要： 继上期,本刊又邀请我国低氧研究领域的专家撰文,简述2019年诺贝尔生理学或医学奖获得者发现细胞如何感知和适应氧浓度变化的研究,探讨低氧诱导因子(HIF)信号通路对相关生理及病理生理过程的认识和对疾病干预靶点的意义,以及HIF通路发现的成功转化--HIF-PHD抑制剂(PHD inhibitor, PHI)治疗肾性贫血。

关键词： 动物生理学实验   教学改革   探索  

摘要： 动物生理学实验是一门独立开设的、实践性较强的课程,是动物科学和动物医学专业必修的专业基础课。通过动物生理学实验的学习拥有稳固的基础知识和过硬的实践技能是重要目标。为使学生更好地掌握该门课程,适时合理地进行教学改革迫在眉睫。通过简述动物生理学实验传统教学现状、改变现有的教学模式和相应的考核机制,因材施教,分类教学,以期通过教学改革使学生在巩固理论知识的同时掌握实验基本技能,提高实践创新能力及综合素质。

关键词： OBE教育理念   动物生理学   实验教学  

摘要： 文章首先对OBE教育理念进行了概述,然后分析了动物生理学实验教学现状,最后提出了基于OBE教育理念的动物生理学实验教学改革策略,包括以学习成果为导向,改革实验教学内容;转变教学模式,提倡参与式教学,发挥学生主体作用;建立多元化课程评价体系。

关键词： 高职医学   生理学   实践教学   改革  

摘要： 随着职业教育的不断发展和完善,为实现高职医学教育培养目标,医学生理学课程整合势在必行。医学实 践教学是医学教育的重要组成部分,是深化理论知识、强化专业知识,培养学生实践操作能力和创新能力的关键环 节,是提高学生专业素质和增强就业竞争力的重要途径。文章探讨高职医学生理学实践教学改革内容,培养出符合 现代医学要求的应用型高级技术人才。

关键词： 运动生理学   中职   体育   训练   应用  

摘要： 运动生理学是中职体育院校教学中一门基础性理论学科,主要研究人体对运动的反应及适应能力。运动生理学的学习及应用为中职体育院校学生专项训练提供有效的理论参考依据。因此,通过浅谈中职体育院校运动生理学在田径、足球、篮球等专项训练中的应用情况,为中职体育院校教练员制定科学、合理的训练计划和内容提供理论和实践参考。

关键词： 3D   口腔解剖   教学  

摘要： 口腔解剖生理学是口腔医学生的专业基础必修课。但口腔颌面部的解剖形态结构复杂,学生难以理解和掌握,同时尸体标本的来源匮乏。故课题组人员探索将院校与上海桥媒信息科技有限公司合作开发的数字化3D虚拟口腔解剖教学平台应用到口腔解剖生理学教学中,改变了学生被动的学习状态,激发了学生的主动学习兴趣,并取得了较好的教学效果。

关键词： 职教云   3D   body   解剖生理学   高职药学  

摘要： 探讨职教云联合3D body软件在高职药学专业人体解剖生理学教学中的应用价值。以河南护理职业学院2018级药学专业的两个教学班为研究对象,其中药学1班采用传统理论课教学;药学2班采用职教云联合3D body软件进行教学。在学期末,对两个班的考试成绩、对课程的整体评价进行统计学分析。结果发现,在高职解剖生理学教学中采用职教云联合3D body软件教学能显著提高教学质量,值得推广应用。

关键词： kidney   kinetics   organic cation   transport  

摘要： Organic cation transporters play a critical role in mediating the distribution of cationic pharmaceuticals. Indeed, organic cation transporter (OCT)2 is the initial step in the renal secretion of organic cations and consequently plays a defining role in establishing the pharmacokinetics of many cationic drugs. Although a hallmark of OCTs is their bmad selectivity, this characteristic also makes them targets for unwanted, adverse drug-drug interactions (DDIs), making them a focus for efforts to develop models of ligand interaction that could predict and preempt these adverse interactions. This review discusses the molecular characteristics of these transporters as well as the evidence that established the OCTs as key players in the distribution of organic cations. However, the primary focus is the present understanding of the complexity of ligand interaction with OCTs, particularly OCT2, including evidence for the presence of multiple ligand-binding sites and the influence of substrate structure on the affinity of the transporter for inhibitory ligands. This leads to a discussion of the complexities associated with the development of protocols for assessing the inhibitory potential of new molecular entities to perpetrate unwanted DDIs. the criteria that should be considered in the interpretation of the results of such protocols. and the challenges associated with development of models capable of predicting unwanted DDIs.

关键词： animal use alternatives   instructional films and videos   physiology   problem-based learning   virtual laboratories  

摘要： Over the years, much criticism against animal use for physiology teaching has been made. Hence, replacement by suitable alternatives has increased in several pedagogical approaches. This study examined students' perceptions of animal versus virtual (video/computer) laboratory classes in physiological sciences associated with the effectiveness of the problem-based learning (PBL) hybrid curriculum. Three cohorts of medical students from the University of Ribeirao Preto, who participated in animal or virtual physiology classes or both, were asked to fill out a 5-point Likert questionnaire about knowledge acquisition/motivation, importance to PBL learning goals, skills acquired. need for animal use, academic formation, learning impairment, and alternative methods. We also assessed their grades in the final exam. A total of 350 students were included, in which 108 participated only in virtual classes, 120 only in practical animal laboratory classes, and 122 in both approaches. The majority agreed that the two methods improved their knowledge acquisition/motivation and helped to reinforce tutorial goals and to acquire skills. However, the cohort who experienced both approaches favored animal laboratory. Students believe animal use is needed and did not impair their learning. Conversely, their opinion about academic formation without animal laboratory classes was divided, as was whether this approach inspired them to seek alternative methods. Despite the different perceptions, there was no difference among the groups' final grades (7.3 +/- 1 vs. 7.2 +/- 1 vs. 7.2 +/- 2 for virtual or practical animal laboratory classes or both, respectively). Therefore, virtual activities are not as effective as animal use in the opinions of the students, but they are successful strategies in physiology learning that can be used in practical classes in a hybrid PBL curriculum.

关键词： Native T1   Native T2   Stress cardiovascular magnetic resonance   Quantitative perfusion   Myocardial blood volume   Extracellular volume   Mapping  

摘要： Background: Both ischemic and non-ischemic heart disease can cause disturbances in the myocardial blood volume (MBV), myocardial perfusion and the myocardial extracellular volume fraction (ECV). Recent studies suggest that native myocardial T1 mapping can detect changes in MBV during adenosine stress without the use of contrast agents. Furthermore, native T2 mapping could also potentially be used to quantify changes in myocardial perfusion and/or MBV. Therefore, the aim of this study was to explore the relative contributions of myocardial perfusion, MBV and ECV to native T1 and native T2 at rest and during adenosine stress in normal physiology. Methods: Healthy subjects (n = 41, 26 +/- 5 years, 51% females) underwent 1.5 T cardiovascular magnetic resonance (CMR) scanning. Quantitative myocardial perfusion [ml/min/g] and MBV [%] maps were computed from first pass perfusion imaging at adenosine stress (140 microg/kg/min infusion) and rest following an intravenous contrast bolus (0.05 mmol/kg, gadobutrol). Native T1 and T2 maps were acquired before and during adenosine stress. T1 maps at rest and stress were also acquired following a 0.2 mmol/kg cumulative intravenous contrast dose, rendering rest and stress ECV maps [%]. Myocardial T1, T2, perfusion, MBV and ECV values were measured by delineating a region of interest in the midmural third of the myocardium. Results: During adenosine stress, there was an increase in myocardial native T1, native T2, perfusion, MBV, and ECV (p <= 0.001 for all). Myocardial perfusion, MBV and ECV all correlated with both native T1 and native T2, respectively (R-2 = 0.35 to 0.61, p < 0.001 for all). Multivariate linear regression revealed that ECV and perfusion together best explained the change in native T2 (ECV beta 0.21, p = 0.02, perfusion beta 0.66, p < 0.001, model R-2 = 0.64, p < 0.001), and native T1 (ECV beta 0.50, p < 0.001, perfusion beta 0.43, p < 0.001, model R-2 = 0.69, p < 0.001). Conclusions: Myocardial native T1, native T