生理学-文献订阅-三峡大学图书馆

王步标华明

肖茜

中国科学院生物物理研究所

摘要： 非哺乳动物的离顶盖通路被认为是哺乳动物上丘—丘脑枕(pulvinar)—纹皮层外通路的同源结构。家鸽的离顶盖通路是从顶盖发出纤维输出到圆核，后者又投射到端脑的内皮质。本文采用细胞外记录技术，首次在家鸽端脑内皮质记录到检测碰撞信息即对迫近运动敏感的细胞。根据它们的脉冲发放特征，将其分为tau细胞和eta细胞。Tau细胞开始发放的时间不随刺激球的大小和运动速度的改变而改变，它们都在碰撞前某个固定时间开始发放;eta细胞开始发放的时间和刺激球直径与运动速度比值的平方根成线性关系。对标记的记录位置分析后发现，实验中记录到的对迫近运动敏感的细胞均位于内皮质的尾侧。通过计算机扫描技术检测这些细胞的感受野，笔者发现迫近运动敏感细胞的感受野有三种类型：eta细胞的感受野为中心抑制区外周兴奋区的同心圆式结构，兴奋区外面没有抑制区;tau细胞的感受野包括两类：全兴奋区的感受野结构以及兴奋区和抑制区并列的结构。同时，细胞感受野的抑制区在对碰撞信息的检测中不起抑制作用。由此看来，家鸽端脑内皮质存在检测碰撞信息的细胞，但它对碰撞信息的检测不依赖于二维扫描得到的感受野结构。

现代生理学实验教程第3版

沈岳良陈莹莹

来源详细信息

信息

来源详细信息

关键词： 体适能华人运动生理学运动营养食品

摘要： 第2届北京国际运动营养食品高层论坛即将举行[本刊讯]第2届北京国际运动营养食品高层论坛将于2006年8月7日-10日在北京召开。本届高层论坛由中国体育科学学会、中国食品科学技术学会主办,北京市昌平区政府、中国食品科学技术学会运动营养食品分会、北京康比特公司承办。本届论坛将以“运动营养与竞技能力和国民健康”为主题,旨在推动我国运动营养食品行业的快速发展,更好地服务于全民健身以及奥运会竞技体育备战,并满足国内运动营养产业与国际接轨的需要。届时将会聚国内外体育界、食品界、卫生界知名运动营养学专家,进行大会专题报告。论坛邀请到4位来自新西兰、德国、美国的运动营养专家和13位国内专家讲学,共同深入分析国际国内“与运动营养相关的多项产业”的发展现状和前景展望。同时,论坛还将围绕运动营养与奥运金牌、健身健美与运动营养、运动营养与学校体育、女性和老年人健康与运动营养、国内外运动营养产业的发展及展望等作专题讲座,并进行论文报告。第5届“华人运动生理及体适能学者学会”年会将于今年10月召开[本刊讯]第5届“华人运动生理与体适能学者学会”(SocietyofChineseScholaronExercisePhysiology&Fi...

Comparison of gene expression signatures of diamide, H2O2 and menadione exposed Aspergillus nidulans cultures -: linking genome-wide transcriptional changes to cellular physiology -: art. no. 182

Pócsi, I Miskei, M Karányi, Z Emri, T Ayoubi, P Pusztahelyi, T Balla, G Prade, RA

Univ Debrecen Fac Sci Dept Microbiol & Biotechnol H-4010 Debrecen HungaryUniv Debrecen Fac Med Dept Med H-4012 Debrecen HungaryOklahoma State Univ Dept Biochem & Mol Biol Stillwater OK 74078 USAUniv Debrecen Fac Med Dept Neonatol H-4012 Debrecen HungaryOklahoma State Univ Dept Microbiol & Mol Genet Stillwater OK 74078 USA

来源 BioMed Central期刊

详细信息

关键词： Gene Probe Responsive Gene Menadione Diamide Ntf2

摘要： Background: In addition to their cytotoxic nature, reactive oxygen species (ROS) are also signal molecules in diverse cellular processes in eukaryotic organisms. Linking genome-wide transcriptional changes to cellular physiology in oxidative stress-exposed Aspergillus nidulans cultures provides the opportunity to estimate the sizes of peroxide (O-2(2-)), superoxide (O-2(center dot-)) and glutathione/glutathione disulphide (GSH/GSSG) redox imbalance responses. Results: Genome-wide transcriptional changes triggered by diamide, H2O2 and menadione in A. nidulans vegetative tissues were recorded using DNA microarrays containing 3533 unique PCR-amplified probes. Evaluation of LOESS-normalized data indicated that 2499 gene probes were affected by at least one stress-inducing agent. The stress induced by diamide and H2O2 were pulse-like, with recovery after 1 h exposure time while no recovery was observed with menadione. The distribution of stress-responsive gene probes among major physiological functional categories was approximately the same for each agent. The gene group sizes solely responsive to changes in intracellular O-2(2-), O-2(center dot-) concentrations or to GSH/GSSG redox imbalance were estimated at 7.7, 32.6 and 13.0 %, respectively. Gene groups responsive to diamide, H2O2 and menadione treatments and gene groups influenced by GSH/GSSG, O-2(2-) and O-2(center dot-) were only partly overlapping with distinct enrichment profiles within functional categories. Changes in the GSH/GSSG redox state influenced expression of genes coding for PBS2 like MAPK kinase homologue, PSK2 kinase homologue, AtfA transcription factor, and many elements of ubiquitin tagging, cell division cycle regulators, translation machinery proteins, defense and stress proteins, transport proteins as well as many enzymes of the primary and secondary metabolisms. Meanwhile, a separate set of genes encoding transport proteins, CpcA and JlbA amino acid starvation-responsive transcription factors,

口腔医学基础——口腔解剖生理学

来源详细信息