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摘要： 中华医学会神经病学分会肌电图与临床电生理学组和中华神经科杂志编辑委员会初步拟定，2014年8月底在贵州省贵阳市召开第13届全国肌电图与临床神经电生理学术会议暨规范化研讨会。届时将邀请肌电图和临床神经电生理学组的著名专家授课及主持会议。大会现面向全国广大肌电图和临床电生理研究人员进行征稿，欢迎大家积极投稿，参会者将获得国家级I类继续教育学分10分。

摘要： 中华医学会神经病学分会肌电图与临床电生理学组和中华神经科杂志编辑委员会初步拟定于2014年8月28—30日在贵州省贵阳市召开第13届全国肌电图与临床神经电生理学术会议暨规范化研讨会。会议继承了每2年召开1次神经电生理相关学术会议进行学术交流的优良传统，将邀请肌电图和临床神经电生理学组的著名专家授课及主持会议。现面向全国广大肌电图和临床电生理研究人员进行征稿，欢迎大家积极投稿。参会者将获得国家级Ⅰ类继续教育学分10分。

关键词： 生理学   课堂教学质量   医学生  

摘要： 生理学是生物科学的一个分支,是以生物机体的生命活动现象和机体各个组成部分的功能为研究对象的一门科学。是医学院校相关专业学生的入门课程和必修主干课程。生理学内容多,理论性强而抽象,课时少,是以解剖学、组织胚胎学等基础学科为基础,以药理学、病理生理学为桥梁,并与临床各学科发生有机联系的课程,在医学课程体系中作用非常重要。因此,做好生理学课堂教学,提高课堂教学质量就显得尤为重要。

关键词： 中医药院校   生理学   实验课   虚拟实验   教学  

摘要： 在中医药院校生理学的教学过程中,使用虚拟实验方法,在虚拟的实验环境中较为真实的模拟完成实验,可以提高学生学习兴趣,加深对课程内容的理解,有效缓解教学目标与现有实验条件不足、实验学时受限的矛盾,并为中医药院校生理学实验教学提供新的思路。

关键词： 解剖生理学   心理   医学生  

摘要： 对医学生学习解剖生理学的心理进行剖析,他们存在的问题有:动机不良,不愿学;兴趣不浓,不好学;情感不强,不乐学;意志不够,不勤学;方法不妥,不善学。采取的对策是:激发学习动机,增强学习兴趣,培养学习热情,磨炼学习意志,加强教学研究。

关键词： ovary   signaling   catecholamine   computational model   polycystic ovary syndrome  

摘要： STUDY QUESTION: Is the neurotransmitter dopamine (DA) in the human ovary involved in the generation of reactive oxygen species (ROS)? SUMMARY ANSWER: Human ovarian follicular fluid contains DA, which causes the generation of ROS in cultured human granulosa cells (GCs), and alterations of DA levels in follicular fluid and DA uptake/metabolism in GCs in patients with polycystic ovary syndrome (PCOS) are linked to increased levels of ROS. WHAT IS KNOWN ALREADY: DA is an important neurotransmitter in the brain, and the metabolism of DA results in the generation of ROS. DA was detected in human ovarian homogenates, but whether it is present in follicular fluid and plays a role in the follicle is not known. STUDY DESIGN, SIZE AND DURATION: We used human follicular fluid from patients undergoing in vitro fertilization (IVF), GCs from patients with or without PCOS and also employed mathematical modeling to investigate the presence of DA and its effects on ROS. PARTICIPANTS/MATERIALS, SETTING AND METHODS: DA in follicular fluid and GCs was determined by enzyme-linked immuno-sorbent assay. GC viability, apoptosis and generation of ROS were monitored in GCs upon addition of DA. Inhibitors of DA uptake and metabolism, an antioxidant and DA receptor agonists, were used to study cellular uptake and the mechanism of DA-induced ROS generation. Human GCs were examined for the presence and abundance of transcripts of the DA transporter (DAT;SLC6A3), the DA-metabolizing enzymes monoamine oxidases A/B (MAO-A/B) and catechol-O-methyltransferase and the vesicular monoamine transporter. A computational model was developed to describe and predict DA-induced ROS generation in human GCs. MAIN RESULTS AND ROLE OF CHANCE: We found DA in follicular fluid of ovulatory follicles of the human ovary and in GCs. DAT and MAO-A/B, which are expressed by GCs, are prerequisites for a DA receptor-independent generation of ROS in GCs. Blockers of DAT and MAO-A/B, as well as an antioxidant, prevented the g

关键词： breast cancer   lactation   mammary epithelium   secretory pathway   SPCA2  

摘要： Breast cancer is the second leading cause of cancer mortality in women, estimated at nearly 40,000 deaths and more than 230,000 new cases diagnosed in the U. S. this year alone. One of the defining characteristics of breast cancer is the radiographic presence of microcalcifications. These palpable mineral precipitates are commonly found in the breast after formation of a tumor. Since free Ca2+ plays a crucial role as a second messenger inside cells, we hypothesize that these chelated precipitates may be a result of dysregulated Ca2+ secretion associated with tumorigenesis. Transient and sustained elevations of intracellular Ca2+ regulate cell proliferation, apoptosis and cell migration, and offer numerous therapeutic possibilities in controlling tumor growth and metastasis. During lactation, a developmentally determined program of gene expression controls the massive transcellular mobilization of Ca2+ from the blood into milk by the coordinated action of calcium transporters, including pumps, channels, sensors and buffers, in a functional module that we term CALTRANS. Here we assess the evidence implicating genes that regulate free and buffered Ca2+ in normal breast epithelium and cancer cells and discuss mechanisms that are likely to contribute to the pathological characteristics of breast cancer.

关键词： 神经电生理学   贵阳医学院附属医院   临床工作者   稿约   杂志   癫痫   学术刊物   中华医学会  

摘要： 一、本刊由中华医学会神经病学分会脑电图与癫痈学组和贵阳医学院联合主办，由贵阳医学院附属医院承办，是目前我国癫痈与临床神经电生理专业唯一经批准国内外公开发行的学术刊物。本刊的宗旨是为我国癫痈学，临床神经电生理学及神经科临床工作者提供一个学术园地，

关键词： 动物生理学实验   教学改革   考核方法改进  

摘要： 动物生理学实验教学对本科生基本实验操作技能和创造性实验能力的培养具有重要意义,改进动物生理学实验教学和考核方法可以指导和检验学生更好的学习和掌握实验课程。在传统的教学和考核方法基础上对动物生理学实验课程教学环节和考核方法进行合理改进,重在紧扣教学各个环节,突出对学生实验操作能力的培养,对学生是一个提高能力的好手段,得到学生的肯定,教学效果良好。

关键词： 植物生理学   实验教学   创新能力  

摘要： 为培养学生的实验创新能力,本文从三个方面探讨了植物生理学实验教学中创新能力的培养:更新实验教学内容,加强综合性及设计性实验能力的培养;改革实验教学模式,创新实验教学方法;健全实验考核制度,创新课程评价方式。