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关键词： 课程思政   思想政治理论课   组织学与胚胎学   立德树人   医学高校   全国高校思想政治工作会议   课堂教学   本科阶段  

摘要： 习近平总书记2016年在全国高校思想政治工作会议上提出“课程思政”这一理念,指出高校要利用好课堂教学这个主渠道,让各类专业课程与思想政治理论课同向同行,形成协同效应[1],更好地完成“立德树人”这一教育根本任务。许多高校已经开始积极探索课程思政,然而纵观当前的研究现状,对“课程思政”的探索大多是从宏观层面出发,缺乏结合具体教学知识点的思政元素分析与挖掘。本文将结合组织学与胚胎学课程中的部分教学内容进行思政点探索与设计,同时希望对国内医学高校本科阶段专业课程思政教学改革起到一定借鉴作用。

关键词： 组织学与胚胎学   SPOC   课程建设  

摘要： 响应教育部打造"金课"及"信息化教育"改革,利用超星学习通网络教学平台,全新创建SPOC的所有组织学与胚胎学课程资源,为实现线上线下的自主学习、合作学习、移动学习、创新性学习、混合学习、个性化学习和探究性学习打下基础,从而提高教学质量。

关键词： 组织学与胚胎学   教学能力   青年教师   培养  

摘要： 组织学与胚胎学是一门重要的基础医学课程,由于其知识枯燥无味,学生学习存在一定的困难。对于青年教师而言,如何提高组织学与胚胎学的教学能力,是一个极大的挑战。本文从开展岗前培训、青年教师导师制的实行、听课、教案及课件的准备、课前试讲、进行课后反思、积极参与教学类竞赛、积极参与教学研究等方面阐述青年教师教学能力的培养措施。

关键词： 多种教学法   组织胚胎学   教学效果  

摘要： 组织学与胚胎学是医学生进入大学首先学习的专业基础课,其组织学内容主要是研究显微镜下的组织形态结构以及结构与功能的关系,胚胎学内容是研究受精卵的形成及人体的发育过程中形态结构变化规律。传统的教学法图片小、清晰度低,内容抽象枯燥、板书失真、呆板,学生不容易理解和学习。随着教学手段的不断改进,教学经验逐渐丰富,逐渐摸索实践经验,该研究发现以PPT多媒体教学形式为主要形式,课堂教学形式灵活多样、内容不断丰富,适时把学科间的联系、营养学知识、执业医师考试大纲、基本案例等有机的应用到教学中,从而激发学生的学习兴趣,活跃了课堂氛围,教学质量也得到了很大的提高,为后期临床课的学习打下了坚实的基础。

关键词： 基础医学  

ISBN: (纸本)9787030683540

摘要： 本书在《组织学与胚胎学学习指导》（第一版）的基础上修订完成，体现以学生为中心、以培养岗位胜任力为导向的指导思想，内容上主要参照《组织学与胚胎学》（唐军民、张雷主编，2018），并补充吸取国内外医学院校编著的教材及相关资料进行编写。全书共25章，每章包括大纲要求、学习要点、复习题和参考答案四部分内容。

关键词： Anti-M?llerian hormone   Antral follicle count   IVF?embryo transfer   Number of embryos   Poor ovarian response   POSEIDON criteria  

摘要： Research question: What is the association between serum anti-M?llerian hormone (AMH) concentrations and the number of utilizable embryos obtained per stimulation cycle of IVF/intracytoplasmic sperm injection (ICSI) in POSEIDON Groups 3 and 4? Design: Retrospective cohort study of 412 cycles, in which patients in POSEIDON Groups 3 and 4 (antral follicle count [AFC] ?5 and AMH <1.2 ng/ml) underwent complete IVF/ICSI treatment cycles in the Reproductive Center of the First Affiliated Hospital of Xinjiang Medical University between January 2017 and March 2019. Patients underwent IVF/ICSI treatment using either progestin-primed ovarian stimulation (PPOS) or gonadotrophin-releasing hormone (GnRH) antagonist protocol as ovarian stimulation protocol. Results: Three models were established to analyse the correlation between AMH and the number of utilizable embryos in this study. After adjusting for covariates (age, baseline FSH, stimulation protocol and AFC), the number embryos increased by 0.1 (95% confidence interval [CI] 0.06?0.14) with each increment of 0.1 ng/ml in AMH concentration. AMH was transformed from a continuous variable to a categorical variable (through trisection of AMH concentrations) and for the sensitivity analysis it was found that the number of embryos in the high AMH group (0.52?1.19 ng/ml) was 0.62 (95% CI 0.37?0.97) higher than in the low AMH group (0.06?0.24 ng/ml). Conclusions: High AMH in patients in POSEIDON Groups 3 and 4 was found to be associated with an increase in the number of available embryos in IVF/ICSI. The potential reproductive prognosis can be assessed by AMH, to reduce the abandonment of treatment due to underestimation or to implement multiple ineffective stimulation cycles of treatment.

关键词： Embryonic stem cell   DEGs   Hypoxia   HIF-1α   H2afz  

摘要： Background Under hypoxia, mouse embryonic stem cells (mESCs) lose the ability to self-renew and begin to differentiate through down-regulation of LIFR-STAT3 pathway via hypoxia-inducible factor-1 alpha (HIF-1 alpha). However, it remains largely unknown what kinds of factors are involved in hypoxia-induced differentiation of mESCs. Purpose This study aims to identify the differentially expressed genes (DEGs) in early differentiation of mESCs under hypoxia. Methods Here we utilized a Genefishing technique (TM) to discover the new DEGs during hypoxia-induced early differentiation in CCE mESCs. Next, we investigated the role of DEGs using morphological observation, alkaline phosphatase (ALP) assay, STAT3 activation analysis, and biomarkers analysis for stemness. Results We detected 19 DEGs under hypoxia and performed cloning with sequencing in six genes. We confirmed the expression patterns of five DEGs including H2afz and GOT1 by realtime PCR assay. Among them, H2afz was significantly decreased under hypoxia, depending on HIF-1 alpha. H2afz-overexpressing CCE mESCs maintained their ALP activity and stem cell markers (Nanog and Rex1), even in hypoxic condition. On the other hand, the early differentiation markers such as FGF5 and STAT5a, which had been increased in hypoxic conditions, were reduced by H2afz overexpression. Conclusion We discovered that H2afz could be a new target gene that functions in hypoxia-induced differentiation in mESCs and have revealed that it is involved in maintaining the pluripotency of mESCs in the early stages of differentiation. These findings will provide insights into mechanisms of hypoxia-mediated differentiation of mESCs during early development.

关键词： 组织学   胚胎学   理实一体化  

摘要： 组织胚胎学为形态学科,是主要的基础课程之一,为有效提高组织胚胎学教学成效,深化学生对此课程相关知识的理解及认识,在课堂中采取理实一体化教学,使理论与实践有机结合,发挥教师主导作用,激发学生学习情绪,丰富课堂内容,实现组织胚胎学教学质量的提高目的。

关键词： 对分课堂   组织学与胚胎学   教学改革  

摘要： 对分课堂是基于国内本土教育形势下提出的一种课堂教学改革新模式。我们将对分课堂模式运用于我校生物技术本科专业基础课组织学与胚胎学的教学中,旨在提高组织学与胚胎学的教学质量,推进课程教学的改革与实践。结果发现,学生学习的积极性和兴趣得到激发,学生的个性化发展得到促进,学生自主学习能力得到提高,同时培养了学生对于中国传统文化的认同以及健康中国的理念。

关键词： 混合式教学   组织学与胚胎学   教学改革  

摘要： 混合式教学法对于作为基础医学的组织学与胚胎学教学有着十分重要的意义。教师通过混合式教学法可以让学生经过传统模式的教学方法,在实验室中学习组织学与胚胎学的基本知识,另一方面通过线上的信息化教学手段,让学生对于人体微细结构有更深入的理解。这对于解决目前组织学与胚胎学学科中存在的“内容繁杂、学生学习思路不清晰”、“组织学知识点分散、学生牢固记忆难度大”等现象有着天然的优势。一是能够有效提升学生的学习兴趣,二是可以把组织学与胚胎学相关知识点形成有机的知识网络。