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关键词： 行为康复训练   精神发育迟滞   生活质量  

摘要： 目的:研究行为康复训练提升精神发育迟滞患者生活质量的应用效果.方法:现选取2018年2月-2019年2月期间内,于我院接受治疗的精神发育迟滞的患者70例,将开展常规康复护理的35例设定为A组,将开展常规康复护理与行为康复训练的35例设定为B组,分析比较两组患者的临床护理结果.结果:护理后,B组患者的各项NOSIE评分均明显低于A组,P＜0.05;且B组患者的各项生活质量评分均明显高于A组,P＜0.05.结论:行为康复训练应用于精神发育迟滞患者的临床护理中效果显著,可有效提升患者的生活质量,值得推广运用.

关键词： Business administration  

摘要： JOHN ARTHUR GORY. THE EFFECTS OF VETERAN IDENTITY STRAIN, PTSD, AND SOCIAL SUPPORT ON VETERANS’ JOB SATISFACTION (Under the direction of DR REGINALD A. SILVER) Military veterans transitioning from the Armed Forces to the civilian workforce face many challenges and obstacles such as anxiety, depression, unemployment, and unstable work relations. As of September 2017, there were over 4.2 million United States veterans from the post-9/11 era alone. More than 5 million U.S. veterans are expected to return to our communities and the civilian workforce by the year 2020 (Stern, 2017). The vast majority of Americans have little understanding of military service or the impact service may have on civilian employment outcomes (Taylor, Morin, & Parker, 2011). With tens of thousands of veterans having returned from Iraq and Afghanistan, little focus has been concentrated on post deployment reintegration efforts into the civilian workforce. The present dissertation explores veteran reintegration by evaluating the association between veteran identity strain (Vet-IS) and job satisfaction. It also investigates how the relationship between Vet-IS and job satisfaction may be influenced by perceived social support and Posttraumatic Stress Disorder (PTSD). Data were collected via a 60-item electronic survey distributed to employed veterans (n=135) in the United States. The proposed research hypotheses were tested using partial least squares – structural equation modeling (PLS-SEM). Results from the analysis demonstrate a statistically significant direct effect of Vet-IS on job satisfaction. However, the moderating effects of both perceived social support and PTSD were found to be nonsignificant on the association between Vet-IS and job satisfaction. The findings are discussed in light of their theoretical and practical implications and suggestions are offered for future research on veteran employment and retention. INDEX WORDS: Veteran Identity Strain, PTSD, Social Support, Job Satisfac

关键词： 双相障碍   精神病   心境稳定剂   躁狂症  

摘要： 目的:研究心境稳定剂联合新型抗精神病药物在双相障碍中的应用效果。方法:随机选择我院2017年2月至2019年2月收治的双相情感障碍躁狂症患者分组进行研究,以随机数字分组的方法,平均分为实验组和对照组,给予两组患者不同治疗方法,判断最终效果。结果:在治疗4周和2个月后的评分中,观察组患者的评分明显低于对照组,观察组患者治疗总有效人数为35例,总有效率为97.22%,1例患者出现了不良反应,所占比重为2.78%,各项结果均优于同期对照组,差异显著有统计学意义(P<0.05)。结论:心境稳定剂联合新型喹硫平药物治疗双相障碍,有积极的临床效果,值得进一步推广和使用。

关键词： Dance   Performing arts  

摘要： This thesis examined how inner healing can be guided when dance is treated as a vessel to explore the root of our private selves by identifying and exposing the inner struggles that shape our moral identity. This study provided an understanding of how the pillar foundations of lived experiences, cultural interactions, and spiritual and/or religious teaching from adolescence to adulthood establish the development of an individual’s moral identity. This inquiry analyzed the connection between moral development, moral code, moral integrity, moral identity, phenomenology, existential phenomenology, and somatic-based practices with the psychological healing inquiries of PTSD and moral injury. From the information gained through the literature research and somatic-based practice more specifically Laban/Bartenieff Fundamentals, it guided the choreographic process to further investigate what holds the potential to reconcile with internal moral struggles as a means toward transforming and reintegrating conflicting natures while driving forward the process of healing.

关键词： 创伤后应激障碍   恐惧记忆   5-HT1A   Rac1   桑螵蛸散  

摘要： 第一部分:恐惧记忆是人或动物遭受威胁性、灾难性刺激时产生的一种记忆,适当的恐惧可以使机体能够更好的适应环境,但过度的恐惧会导致恐惧障碍相关疾病的发生,如创伤后应激障碍。研究发现5-HT系统对情绪记忆,特别是恐惧记忆有重要的调节作用。我们课题组前期研究发现海马Rac1活性调节大鼠背景恐惧记忆的遗忘,5-HT2A受体可调节海马Rac1的活性且两者间有相互作用。大量研究表明5-HT1A受体也参与恐惧记忆的调节,但恐惧学习后海马5-HT1A受体表达变化及下游分子目前没有完全研究清楚,5-HT1A受体是否也能影响海马Rac1的活性仍未知。本课题对此问题进行探讨。目的:探讨背景条件恐惧学习后海马5-HT1A受体的表达变化及其是否通过调节海马Rac1的活性影响大鼠的恐惧记忆。方法:(1)SD大鼠条件背景恐惧学习后免疫组织化学和Western blot(WB)检测海马5-HT1A受体的表达。(2)SD大鼠分三组,海马CA1分别予vehicle+vehicle,vehicle+WAY100635(5-HT1A受体拮抗剂)或WAY100635+NSC23766(Rac1抑制剂)后,检测海马Rac1的活性。(3)免疫共沉淀检测5-HT1A受体与Rac1之间是否有相互作用。(4)大鼠海马CA1分别予vehicle+vehicle,vehicle+WAY100635或WAY100635+NSC23766药理学干预后进行条件恐惧记忆学习,学习后24h进行恐惧记忆的检测。结果:(1)条件恐惧记忆学习后免疫组织化学和蛋白印迹实验显示大鼠海马5-HT1A受体表达上调。(2)海马CA1分别予Vehicle+Vehicle(V+V),Vehicle+WAY100635(V+W)或NSC23766+WAY100635(N+W)后,WB实验结果显示与对照组相比,Vehicle+WAY100635(V+W)组海马Rac1的活性增高(p<0.05),NSC23766+WAY100635组海马Rac1的活性降低(p<0.001)。(3)免疫共沉淀检测5-HT1A受体与Rac1之间存在有相互作用。(4)三组大鼠条件恐惧学习成绩类似,24h提取结果显示与对照组相比,Vehicle+WAY100635组的僵立时间(freezing time)降低(p<0.01),NSC23766+WAY100635组僵立时间与对照组相似。结论:(1)大鼠条件恐惧学习后海马5-HT1A受体的表达上调,伴随着恐惧记忆增强。(2)CA1区予5-HT1A受体拮抗剂后,海马Rac1活性上调,Rac1抑制剂可抵消5-HT1A受体拮抗剂导致的海马Rac1活性的上调。(3)5-HT1A受体与Rac1之间存在有相互作用。(4)抑制海马5-HT1A受体诱发大鼠条件恐惧记忆减弱,抑制海马Rac1活性可消除5-HT1A受体拮抗剂所致的大鼠恐惧记忆减弱。以上结果提示5-HT1A受体通过调节海马Rac1的活性影响大鼠的背景恐惧记忆。第二部分:桑螵蛸散由桑螵蛸、远志、龙骨、人参、茯神、当归、龟甲组成,是祖国医学治疗恐症的经典名方,但其作用机制不十分清楚。海马为学习记忆的关键脑区,研究发现恐惧应激可导致海马结构及功能改变,逆转其变化有助于动物恐惧记忆的清除。我们推测桑螵蛸散可能影响海马的可塑性而发挥作用,为证实此推测我们进行了以下实验。目的:探索桑螵蛸散对大鼠背景条件恐惧记忆形成的作用及潜在机制。方法:成年的雄性SD大鼠随机分成两组,分别灌胃予桑螵蛸散(0.425g/kg)或vehicle一周,后进行大鼠3次0.4m A持续1s的足底电击条件恐惧学习,学习后24h提取。部分大鼠学习前取海马行蛋白印迹实验和免疫组织化学染色,检测学习记忆相关的分子p-CREB、c-fos、p-Pak1、Rac1-GTP的表达变化。结果:(1)与对照组相比,桑螵蛸散组大鼠海马的CA1区(p<0.001)、CA3区(p<0.001)、DG区p-CREB表达上调(p<0.01),CA3区c-fos表达上调(p<0.001);p-Pak1、Rac1-GTP的表达无差异。(2)行为学结果显示桑螵蛸散组大鼠第3次恐惧学习后僵立时间(freezing time)低于对照组(p<0.05),24h提取成绩桑螵蛸散与对照组相比无差异。结论:桑螵蛸散可诱发海马p-CREB、c-fos表达上调,并对大鼠的恐惧学习有抑制作用。

关键词： 盆腔肿瘤   良恶性   血清肿瘤标志物  

摘要： 目的探究血清肿瘤标志物检测在盆腔良恶性妇科肿瘤诊断与鉴别诊断中的意义。方法 2019年3月至2020年3月,共有101例盆腔肿瘤患者在内蒙古医科大学附属人民医院妇科就诊,患者均可提供足量空腹血样送检,以穿刺活检病理学结果为金标准,分析患者的检查结果。结果 101例盆腔肿瘤中,71例良性肿瘤,30例恶性肿瘤。良性肿瘤患者的CEA水平大于恶性肿瘤患者(P<0.05),良性肿瘤患者的CA125、CA153、CA199水平均小于恶性肿瘤患者(P<0.05),良性肿瘤患者的CA125、CA153、CA199阳性率小于恶性肿瘤患者(P<0.05)。结论盆腔肿瘤患者诊断疾病期间,检验血清肿瘤标志物,部分患者的指标明显发生异常,可见具有一定的应用价值。

关键词： 生活技能训练   自我管理小组   精神发育迟滞   社会功能  

摘要： 目的探讨生活技能自我管理小组训练队精神发育迟滞患者社会功能的影响。方法选取我院于2019年1月～2020年6月收治的精神发育迟滞患者68例,随机分为观察组和对照组两组,每组34例。对照组予常规精神病患者护理干预,观察组则在此基础上实施生活技能自我管理小组训练,采用社会功能缺陷评定量表(SDSS)分别在干预前和干预4周后评价并比较两组患者的社会功能。结果干预前两组患者的SDSS评分相似,差异无统计学意义(P>0.05);实施生活技能自我管理小组训练后,观察组患者的SDSS评分显著低于对照组,差异有统计学意义(P<0.05)。结论生活技能自我管理小组通过将精神发育迟滞患者组成小组,对其进行生活技能培训,鼓励组员间互相帮助、监督,有效改善了患者的社会功能和生活自理能力,有助于其日后重返社会。

关键词： Pharmacology   Mental health   Pharmaceutical sciences   Clinical psychology  

摘要： Oxytocin is a psychologically interesting and physiologically complex neuropeptide. Due to its involvement in fear processing and social functioning, oxytocin has been discussed as a potential biomarker for posttraumatic stress disorder (PTSD). This dissertation’s first arm (studies 1 - 5) explored oxytocin’s involvement along the pathway from traumatic event exposure to PTSD symptom development, manifestation, and remission. Studies 1 and 2 covered the stage of PTSD symptom development and its pharmacological prevention. They are based on data from a double-blind, multicenter, randomized, placebo-controlled trial which evaluated the effects of repeated intranasal oxytocin administration early posttrauma on PTSD symptoms one and a half, three and six months later. Study 1 demonstrated that the intervention’s effects, which were beneficial in individuals with high acute PTSD symptoms, were independent of sex and hormonal contraception use. Study 2 demonstrated that higher blood oxytocin concentrations, as assessed early posttrauma, were associated with higher PTSD symptoms at the follow-up timepoints in women using hormonal contraception. No prognostic effects were observed in men or cycling women. Interaction effects with the intervention were observed in none of the groups. Study 3 is a systematic review which summarized studies that investigated endogenous oxytocin concentrations, oxytocin receptor gene DNA variation and methylation in trauma exposed individuals and such with manifest PTSD symptoms. Data on oxytocin receptor gene functioning were insufficient for meta-analysis. The meta-analyses on endogenous oxytocin concentrations showed that they were neither a good biomarker for traumatic event exposure, nor for PTSD symptoms. Especially the observed impact of the biochemical analysis method seems problematic when using endogenous oxytocin concentrations as potential diagnostic biomarker. Studies 4 and 5 covered the stage of PTSD symptom remission related to p

关键词： 脑卒中   短暂性脑缺血发作   创伤后应激障碍   依恋   反刍   药物依从性  

摘要： 目的:探究依恋与反刍思维在脑卒中患者创伤后应激障碍及药物依从性的影响方法:1.选取自2018年12月至2019年9月河北省第二医院神经内科住院部符合临床诊断标准的脑卒中患者300例。行一般资料问卷,关系问卷,美国国立卫生研究院卒中量表或短暂性脑缺血发作评分,亲密关系体验量表,反刍反应量表评估。在3个月后对研究对象进行随访,随访评估PCL-C问卷及Morisky服药依从性量表。2.统计分析:采用SPSS24软件进行数据处理。统计方法包括一般性统计描述、方差分析及回归分析等。结果:本研究274例患者,无PTSD症状占29.6%,轻微PTSD症状占62.8%,有明显PTSD症状占7.7%;依恋回避上均分为3.18±0.85,依恋焦虑均分为3.07±1.17;症状反刍均分19.15±5.70,强迫思考均分9.61±2.80,反省深思均分7.89±2.51;不同依恋类型患者在PTSD得分上的差异有统计学意义,（F=5.936 P=0.006）;不同PTSD程度患者在症状反刍维度上的差异（F=3.712 P=0.026）、强迫思考维度上的差异（F=3.909P=0.021）均有统计学意义。不同PTSD程度患者在依恋回避维度上的差异（F=3.30 P=0.038）、在依恋回避焦虑上的差异（F=4.185 P=0.016）均有统计学意义。PTSD得分与依恋焦虑存在显著相关（r=0.225）,与症状反刍（r=0.197）和强迫思考（r=0.187）存在显著相关。其中症状反刍、强迫思考中介了依恋焦虑与PTSD之间的关系;在各指标上不同用药依从性程度的差异无统计学意义,依恋风格、反刍思维以及PTSD得分与用药依从性均无显著相关。结论:1.脑卒中患者PTSD阳性率较高2.不安全依恋及负性反刍的脑卒中患者PTSD水平较高3.依恋焦虑对PTSD有正向预测作用,症状反刍与强迫思考中介了依恋焦虑与PTSD4.成人依恋风格、反刍思维以及PTSD得分对用药依从性可能没有预测作用