关键词:
Medical imaging
Computer science
Oncology
摘要:
Purpose: To identify opportunities to improve automatic contouring of organs at risk for head and neck cancer patients by developing a convolutional neural network to conduct automatic contouring and comparing its performance to contemporary atlas-based methods. Methods: Using a cohort of 265 anonymized planning CT scans and their associated physician-defined structure set, with 19 set aside for evaluation, a convolutional neural network (CNN) was trained to predict contour data for eleven common organs at risk (OAR) in head and neck cancer patients. Once trained, the neural network predicted contours for the 19 CT scans that were in the evaluation dataset. A commercial deformable atlas-based automatic contour generation function was used to generate competing contour data for the same 19 CT scans. Each output was compared to approved physician-generated manual contours across three quantitative metrics: Dice similarity coefficient (DSC), mean surface distance (MSD), and 95th percentile Hausdorff distance (HD). Performance differences between the modalities on a given metric for each OAR were evaluated for statistical significance using a two-tailed t-test with a p-value threshold of 0.05 to define a statistically significant difference between the modalities. Results: The CNN scored better on all three metrics for both parotid glands and both submandibular glands. For the cochlea and brachial plexus, the CNN scored better on some metrics, and on some metrics, there was no statistically significant difference between the two modalities. For the brain, larynx, and spinal cord, the metrics showed no statistically superior modality. For the brainstem, the CNN contours scored statistically worse than the atlas-based method. The table below shows the percent improvement from the scores of the atlas-based contours to those of the CNN for each OAR category. Categories marked as “N/A” did not meet the significance threshold. [Table omitted] Conclusion: Except for the brains