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关键词： Biomedical discipline   Computer science  

摘要： R-loops play diverse functional roles, but controversial genomic localization of R-loops have emerged from experimental approaches, posing significant challenges for R-loop research. The development and application of an accurate computational tool for studying human R-loops remains an unmet need. Here, we introduce DeepER, a deep learning-enhanced R-loop prediction tool. DeepER showcases outstanding performance compared to existing tools, facilitating accurate genome-wide annotation of R-loops and a deeper understanding of the position- and context-dependent effects of nucleotide composition on R-loop formation. DeepER also unveils a strong association between certain tandem repeats and R-loop formation, opening a new avenue for understanding the mechanisms underlying some repeat expansion diseases. To facilitate broader utilization, we have developed a user-friendly web server as an integral component of R-loopBase. We anticipate that DeepER will find extensive applications in the field of R-loop research.

关键词： BPA   Trophic transfer   Fluctuating temperature   Climate change   Moulting   Growth rate  

摘要： Bisphenol A (BPA), a synthetic organic compound widely used in the production of plastics, is recognized as an emerging contaminant because of its toxicity and the potential risks associated with bioaccumulation in organisms. Despite potential environmental hazards, there is a lack of studies examining BPA toxicity mechanisms and its potential impact on various trophic levels, with even fewer exploring whether global stressors such as temperature can affect the toxicity of BPA in organisms. Our aim was to assess the combined impact of BPA and varying temperature regimes on life-history traits in Daphnia magna. Our results revealed a significant impact of BPA on the growth, reproduction, and accumulated moulting of D. magna, with adverse effects primarily associated with the assimilation of BPA in algae rather than the BPA present in the medium, pointing to a trophic transfer mechanism. The interactive effect between BPA and temperature demonstrated a slight stimulatory effect of low BPA level on D. magna growth rate under warming constant conditions, but an inhibitory under warming fluctuating temperatures. Additionally, a BPA threshold was identified, below which growth became temperature-dependent. This study emphasizes the crucial role of considering temperature in predicting how toxins may affect Daphnia within aquatic food webs.

关键词： Open access  

摘要： There has been some concern about the impact of predatory publishers on scientific research for some time. Recently, publishers that might previously have been considered ‘predatory’ have established their bona fides, at least to the extent that they are included in citation impact scores such as the field-weighted citation impact (FWCI). These are sometimes called ‘grey’ publishers (MDPI, Frontiers, Hindawi). In this paper, we show that the citation landscape for these grey publications is significantly different from the mainstream landscape and that affording publications in these venues the same status as publications in mainstream journals may significantly distort metrics such as the FWCI. © 2024, CC BY.

关键词： Human learning   Computer and information sciences   Pandemics   COVID 19   Algorithms   Numerical analysis   Universities   Virus testing  

摘要： The COVID-19 pandemic had radically changed higher education. The sudden transition to online teaching and learning exposed, however, some benefits by enhancing educational flexibility and digitization. The long-term effects of these changes are currently unknown, but a key question concerns their effect on student learning outcomes. This study aims to analyze the impact of the emergence of new models and teaching approaches on the academic performance of Computer Science students in the years 2019-2023. The COVID-19 pandemic created a natural experiment for comparisons in performance during in-person versus synchronous online and hybrid learning mode. We tracked changes in student achievements across the first two years of their engineering studies, using both basic (descriptive statistics, t-Student tests, Mann-Whitney test) and advanced statistical methods (Analysis of variance). The inquiry was conducted on 787 students of the Lublin University of Technology (Poland). Our findings indicated that first semester student scores were significantly higher when taught through online (13.77 +/- 2.77) and hybrid (13.7 +/- 2.86) approaches than through traditional in-person means as practiced before the pandemic (11.37 +/- 3.9, p-value < 0.05). Conversely, third semester student scores were significantly lower when taught through online (12.01 +/- 3.14) and hybrid (12.04 +/- 3.19) approaches than through traditional in-person means, after the pandemic (13.23 +/- 3.01, p-value < 0.05). However, the difference did not exceed 10% of a total score of 20 points. With regard to the statistical data, most of the questions were assessed as being difficult or appropriate, with adequate discrimination index, regardless of the learning mode. Based on the results, we conclude that we did not find clear evidence that pandemic disruption and online learning caused knowledge deficiencies. This critical situation increased students' academic motivation. Moreover, we conclude that we hav

关键词： Lemierre's syndrome   Fusobacterium necrophorum   mNGS   metabolic syndrome   case report   odontogenic infection  

摘要： Background: Lemierre's syndrome is a rare and serious complication of pharyngitis with an estimated annual incidence of 1 in 100,000 people worldwide. It is characterized by septic thrombophlebitis of the internal jugular vein with metastatic infection, usually after oropharyngeal infection. Rare cases of Lemierre's syndrome have been reported to be caused by odontogenic infection. Case report: A 33-year-old male visited our hospital with symptoms of fever and sore throat for 16 days. The other symptoms included pain in his left neck and shoulder. In addition, metabolic syndrome was diagnosed based on waist circumference, diabetes, and hyperlipidemia. Fusobacterium necrophorum bacteria was detected using the metagenomic next-generation sequencing (mNGS) technique. The enhanced computerized tomography (CT) scan showed thrombosis of the left proximal jugular vein and brachiocephalic vein. Based on these observations, Lemierre's syndrome was diagnosed. The etiology was that the fillings in the root canal tooth were lost with no blood or pain about 2 weeks before the onset. The patient recovered after treatment with antibiotics and blood purification. Conclusion: Lemierre's syndrome should be evaluated for patients with fever, sore throat, and neck pain. If the loss of fillings from root canal therapy occurs, especially for those with metabolic syndrome, we should be aware of the possibility of this disease. Furthermore, the mNGS test can be used as a crucial supplementary diagnostic tool for patients with undetermined fever.

关键词： Computer science   Machine learning   Society  

摘要： In a test of the chatbot's language abilities it fails at certain languages.

关键词： Management Board   Position Statement   Vice President   Technical Actions   Computer Science   Parallelization   Computer Technology   Electrical Engineering   Industrial Systems   Software Engineering   Steering Committee   Research Software   Young Professionals   Diversity And Inclusion   Opportunities For Members   Technical Community   University Of Waterloo   Department Of Computer Science   Peer Reviewed Conference   Blockchain   Cybersecurity   Technical Leadership   University Of Toronto   Years Of Experience   Supply Chain Management  

摘要： Provides society information that may include news, reviews or technical notes that should be of interest to practitioners and researchers.

关键词： Computer science   Machine learning   Society  

摘要： The Large Language Models that power chatbots are known to struggle in languages outside of English — this podcast explores how this challenge can be overcome.

关键词： Careers   Lab life   Computer science  

摘要： Do fewer things, work at a natural pace and obsess over quality, says computer scientist Cal Newport, in his latest time-management book.