关键词:
Chicken
Coccidia
Gene vaccine
Research progress
摘要:
Coccidiosis is a protozoan disease that seriously threatens the poultry in-dustry. At present, the prevention and treatment of chicken coccidiosis mainly rely on chemical drugs and coccidia live vaccine. However, drug control has problems of drug resistance and drug residue, and the coccidia live vaccine has drawbacks of pathogenicity, high production costs and virulence enhancement. Instead, genetic en-gineering vaccine is easy to operate, stable, safe and efficient, so it has become a hot spot in the prevention of chicken coccidiosis. In this paper, the research status, immune mechanism, immune effect's influencing factors and cytokine adjuvant appli-cation of genetic engineering vaccine against chicken coccidiosis were reviewed to provide some reference for the research and application of chicken coccidiosis gene vaccine.