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关键词： 静息态功能磁共振成像   功能连接   功能分区   t-分布随机邻域嵌入   自动谱聚类  

摘要： 本文针对目前脑功能分区不够准确的问题,基于静息态功能磁共振数据,提出了一种融合t-分布随机邻域嵌入(t-SNE)与自动谱聚类(ASC)的人脑功能精细分区的算法.首先,基于静息态功能磁共振图像,对需功能划分的脑区与全脑的时间序列作相关分析,得到需划分脑区的功能连接模式;然后,利用t-SNE算法提取高维功能连接模式特征;最后,通过基于本征间隙的ASC算法自动确定聚类数目,并对降维后的脑区特征分类,得到精细划分的脑亚区.模拟种子区域上的实验结果表明,相较谱聚类算法,以及结合主成分分析的谱聚类算法,本文方法对脑功能体素划分更优.进一步将本方法应用到真实人脑的功能分区中,成功地将海马旁回分为左右半球各3个亚区.本研究表明使用t-SNE与ASC融合的算法可提高脑功能分区准确性,是脑功能精细分区、进而构建脑功能图谱的一种有效方法.

关键词： 尖叫声   精雕细琢   阳台  

摘要： 令人讨厌的“臭大姐”说到蝽或者蝽象,同学们可能一头雾水。但如果我换个称呼——臭大姐,大家一定会恍然大悟:“哦!就是那种每年秋天都会飞到阳台窗户上、浑身一股恶臭的臭虫吧!”没错,作为我们平日里常见的昆虫之一,蝽给我们无非就留下了两个印象:特别丑和特别臭,以致很多人在看见它们之后往往都会在伴随着一声“臭虫”的尖叫声中捂着鼻子走开,胆大一些的可能还会在叫声中给这个可怜的小家伙来上几脚。说到臭味,同学们知道为什么我们要用“蝽”这个名字称呼它们吗?

关键词： 公路桥梁   伸缩缝   施工方案  

摘要： 从公路桥梁伸缩缝技术的作用出发,结合某桥梁工程实例,分析了该公路桥梁伸缩缝的施工方案,对伸缩缝施工技术施工前的准备以及具体的施工要点展开研究,重点对该技术的应用效果加以检验,以期为同类工程施工提供参考。

关键词： 无中隔墙连拱隧道   爆破振动控制   设计优化   振动监测  

摘要： 无中隔墙连拱隧道建设技术是连拱隧道发展的新方向,在施工时取消了侧导洞和中导洞,不仅加快了施工进度,还保证了隧道的防排水独立。无中隔墙连拱隧道的后行洞开挖支护是保证隧道结构整体稳定的关键点,云南楚姚高速陈家冲隧道在后行洞开挖施工中采用部分区域人工机械开挖和爆破开挖结合的工艺,并在先行洞衬砌增设减震材料和其他减震措施等,保证了后行洞安全掘进和先行洞衬砌不被震裂。隧道现场振动监测结果表明,使用该技术取得了良好的效果,可为类似工程提供参考。

关键词： Endothelial cells   Raman spectroscopy   Heart   Aorta   Brain   Liver   Kidney  

摘要： Raman spectroscopy is successfully becoming an analytical tool used to characterize alterations in the biochemical composition of cells. In this work, we identify the features of Raman spectra of murine primary endothelial cells (EC) isolated from lungs, heart, liver, brain, kidney and aorta of normal mice, as well as from heart, lung and liver in a murine model of heart failure (HF) in Tgaq*44 mice. Primary cells were measured in suspension immediately after their isolation. Raman images showed that isolated primary EC were elliptical or circular, and did not show organ-specific spectral features for any of the studied organ, i.e. lungs, heart, liver, brain, kidney and aorta. Principal Component Analysis pairwise analysis of primary endothelial cells from FVB mice and Tgaq*44 mice revealed an increased protein content in EC isolated from the heart and increased lipid content in EC isolated from the lung in Tgaq*44 mice. No significant differences were found in the EC isolated from the liver using the same chemometric procedure. To our knowledge, this is the first report in which Raman spectroscopy has been used to characterize the biochemical phenotype of primary murine EC with developing HF. This pilot study shows that Raman-based analysis of freshly isolated primary EC did not revealed organ-specific features, however disease-associated changes were found in the coronary and pulmonary EC in the early stage of heart failure in Tgaq*44 mice.

关键词： 石化工厂布局   安全防护   功能分区   消防道路   防火距离   防爆距离  

摘要： 工厂设施的合理布局以及与危险源之间充足的防护距离,对石化工厂事故灾害的预防和控制具有重要作用。研究发现:工厂设施布局应按照不同的功能分区来组织厂区内部格局,人员集中场所应远离危险源;各功能分区之间用通道分隔,并按照标准规范要求合理设置消防道路;防火距离依据GB 50016《建筑设计防火规范》和GB 50160《石油化工企业设计防火标准》而定;防爆距离根据安全定量风险评估确定,将风险控制在可接受的范围之内,从根本上降低重大事故灾害发生的概率并减少次生灾害。

关键词： breast cancer   microwave ablation   metastasis   NK cells   surgery  

摘要： Surgery is essential for controlling the symptoms and complications of stage IV breast ***,locoregional treatment of primary tumors often results in distant progression,including lung metastasis,the most common type of visceral *** a minimally invasive thermal therapy,microwave ablation(MWA)has been attempted in the treatment of breast cancer,but the innate immune response after MWA has not yet been *** two murine models of stage IV breast cancer,we found that MWA of primary breast cancer inhibited the progression of lung metastasis and improved *** cells were activated after MWA of the primary tumor and exhibited enhanced cytotoxic functions,and the cytotoxic pathways of NK cells were *** experiments showed that NK cells but not CD4+or CD8+T cells played a pivotal role in prolonging ***,we found that compared with surgery or control treatment,MWA of the primary tumor induced completely different NK-cell-related cytokine *** were activated after MWA of the primary tumor and produced IL-15 that activated NK cells to inhibit the progression of *** addition,MWA of human breast cancer stimulated an autologous NK-cell *** results demonstrate that MWA of the primary tumor in metastatic breast cancer inhibits metastatic progression via the macrophage/IL-15/NK-cell *** of the primary tumor may be a promising treatment strategy for de novo stage IV breast cancer,although further substantiation is essential for clinical testing.

关键词： 市政道路   桥梁建设   伸缩缝   施工技术  

摘要： 在开展市政道路桥梁建设工作时,其施工技术的质量会在很大程度上影响工程的质量,其中伸缩缝施工技术是一种常用的技术,但它的实际操作难度相对较高.现场工作人员为了更好地利用该技术进行现场施工操作,需要加强技术注意事项以及技术操作步骤的研究.