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关键词： 活出自己   不锈钢板   在阳台上   房子   阳台   风光带   春夏秋冬  

摘要： 我住渌江风光带,买了二楼大户型的房子,赠送阳台三四十平方米,我们将它制作成阳光房。本来上面是玻璃的,装好没几天,高空石子坠破了两块玻璃,安全起见,干脆装成了不锈钢板,下面用浅黄色的帆布镶嵌在顶上,加上浅黄底色金黄条纹的窗帘,整个阳台的格调感觉很温馨。靠南的一堵墙全部是由玻璃构架而成,阳光一大把“输送”进来,下午太阳西斜时更厉害。我种的花草植物都长得壮实,外面还留了十多个平方米没有封起来,更被我种得绿意盈盈,花香四溢。站在阳台上可以看见清澈的渌江水欢快地流淌着,河岸两边的花草植物随着春夏秋冬的更替而变换着“容颜”。这个房子的阳台是我买了好几套房子中最钟爱最满意的阳台。

关键词： 体型系数   水平构件   《高规》   荷载规范   雨篷   遮阳板   工程事故   双坡  

摘要： 1问题引入JGJ 3—2010《高层建筑混凝土结构技术规程》(简称《高规》)第4.2.8条规定,“檐口、雨篷、遮阳板、阳台等水平构件,计算局部上浮风荷载时,风荷载体型系数不宜小于2.0。”有了《高规》这条规定,雨篷的负风压体型系数μs取值为-2.0是没有争议的。但《高规》没有规定雨篷向下的正风压荷载体型系数如何取值,所以争议较大。很多人觉得不用考虑正风压,原因很简单,从已发生的工程事故来看,基本都是雨篷被吹翻,很少听过被吹掉,也有人认为可参考GB 50009—2012《建筑结构荷载规范》(简称《荷载规范》)表8.3.1第29项“单坡及双坡顶盖”的体型系数来取值,但也觉得与雨篷形式不太一样。对于向下荷载工况控制时,正风压的不利作用是不能忽略的,大雪时将雨篷压塌的事故,谁敢说没有正风压的作用呢?只是《荷载规范》没有规定,每个人的想法肯定不一样,所以执行起来很困难。

关键词： 主体功能区   主体功能区战略和制度   评估调整   国土空间规划  

摘要： 完善主体功能区战略和制度是提升国土空间治理体系和治理能力现代化的重要内容。我国主体功能区十年建设成效显著,三大战略格局基本形成。党的十八大以来,党中央陆续提出一系列新的战略部署,部分地区现有主体功能区定位难以适应国家新的发展理念和战略要求,部分县域主体功能定位难以满足其多元性的发展需求或因行政区划调整导致其主体功能定位与实际情况不符,部分地区主体功能区定位存在评估调整的客观需求。本论述基于《省级国土空间规划编制指南(试行)》,探索建立了"1+3+5"的评估调整体系与方法,构建了"3+N"主体功能分区体系,为各地开展主体功能区评估调整工作提供思路。

关键词： 道路   沥青填充式伸缩缝   胶结料   蠕变试验   黏弹性  

摘要： 以国内生产的沥青填充式桥梁无缝伸缩缝材料(以下简称MUT)为研究对象,采用动态剪切流变仪在8种不同的应力等级下,对其黏弹性进行蠕变试验,并结合一种聚合物模型对试验数据进行拟合,表征并分析了短期老化与温度改变对MUT黏弹性的影响。研究结果表明:短期老化与温度的降低均能够显著降低各个应力等级下的蠕变柔量以及蠕变柔量对于加载时间与加载应力的敏感性,扩大了线性黏弹性的应力范围,增强了MUT抵抗变形的能力;而温度的升高则会造成相反的影响;采用的聚合物模型对于试验结果具有理想的拟合效果,能够良好地表征MUT的黏弹性。

关键词： Perforations   Functionally graded materials (FGM)   Thermomechanical   Flexural   Higher-order   Finite element method (FEM)  

摘要： The flexural behavior of functionally graded composite panels with single and multiple rectangular perforations is examined subjected to complex loading conditions, including uniform/sinusoidal pressure and uniform/linear/nonlinear thermal field. The constituent materials are assumed to be temperature-dependent, whereas the instantaneous material properties are evaluated using the power-law function via Voigt's homogenization scheme. Here, the displacement field is based on the equivalent single-layer higher-order kinematics with nine degrees of freedom. The equations of motion are obtained using minimum total potential energy principle and isoperimetric finite-element approximations via Lagrange elements. The mesh convergence test is carried out to show the stable and appropriate mesh density;however, to check the correctness, the present solution is compared with the benchmark solutions. In addition, new numerical examples are presented to demonstrate the effect of different parameters, such as the number of perforations, power-law coefficients, aspect ratios, loading, and edge conditions on the deflection responses of perforated functionally graded composite panels.

关键词： 隔断墙   电梯   轻质材料   房车   楼梯   阳台   别墅   自动排列  

摘要： 隔断墙德国公司研发的隔断墙会自动排列成墙,把大房间分隔成一个个小房间。每块活动墙是由复合轻质材料制成,上下都嵌在轨道中,可以自由移动形成隔墙。每一块墙就好像列兵一样,排成一队向前走,只要几分钟,一道墙就平地而起。带电梯的房车房车如何住出别墅的感觉?新型房车Life Home V90 Villa Edition,颠覆了传统的房车结构,你只要点一下按钮,车顶就会升起,变成一个二层小楼,并且,还有一个小阳台,方便晒太阳看星星。车内没有楼梯,采用一个单人电梯取代,方便在狭小的空间中升降。

关键词： 阳台   大都市   加固  

摘要： 尽管现在大都市里,日新月异,高楼林立,可我家仍住的是1970年代初期修建的简易楼,三家共用一个厕所,六家共享一个走廊,可以说,要多简易,有多简易。然而,在前些年,工厂却以“防震加固”为由,在楼后为每家“加固”了一个阳台,并将一楼的阳台彻底封了起来,变成了一个斗室。住在一楼的我,从此多了半间房子。

关键词： Adjuvant Therapy   TKI   RCC   Renal Cell Carcinoma   Meta-Analysis  

摘要： PURPOSE: Tyrosine kinase inhibitors (TKIs) have been widely used in the management of patients with metastatic renal cell carcinoma (RCC). However, the use of systemic therapies in the adjuvant setting of localized and locally advanced RCC has shown conflicting results across the literature. Therefore, we aimed to conduct an updated systematic review and meta-analysis comparing the efficacy and safety of TKIs in the adjuvant setting for patients with localized and locally advanced RCC. MATERIALS AND METHODS: The MEDLINE and EMBASE databases were searched in December 2020 to identify phase III randomized controlled trials of patients receiving adjuvant therapies with TKI for RCC. Disease-free survival (DFS) and overall survival (OS) were the primary endpoints. The secondary endpoints included treatment-related adverse events (TRAEs) of high and any grade. RESULTS: Five trials (S-TRAC, ASSURE, PROTECT, ATLAS, and SORCE) were included in our meta-analysis comprising 6,531 patients. The forest plot revealed that TKI therapy was associated with a significantly longer DFS compared to placebo (pooled HR: 0.88, 95% CI: 0.81- 0.96, P=0.004). The Cochrane's Q test (P = 0.51) and I-2 test (I-2 = 0%) revealed no significant heterogeneity. Adjuvant TKI was not associated with improved OS compared to placebo (pooled HR: 0.93, 95% CI: 0.83-1.04, P=0.23). The Cochrane's Q test (P=0.74) and I-2 test (I-2 = 0%) revealed no significant heterogeneity. The forest plot revealed that TKI therapy, compared to placebo, was associated with higher rates of high grade TRAEs (OR: 5.20, 95% CI: 4.10-6.59, P<0.00001) as well as any grade TRAEs (OR: 3.85, 95% CI: 1.22-12.17, P=0.02). The Cochrane's Q tests (P < 0.0001 and P < 0.00001, respectively) and I-2 tests (I-2 = 79% and I-2 = 90%, respectively) revealed significant heterogeneity. CONCLUSIONS: The findings of our analyses suggest an improved DFS in patients with localized and locally advanced RCC receiving adjuvant TKI as compared to placebo

关键词： B-cell development   humoral immunity   immunoglobulin class switch recombination   inborn errors of immunity   predominantly antibody deficiencies   primary immunodeficiency  

摘要： Predominantly antibody deficiencies (PADs) encompass a heterogeneous group of disorders characterized by low immunoglobulin serum levels in the presence or absence of peripheral B cells. Clinical presentation of affected patients may include recurrent respiratory and gastrointestinal infections, invasive infections, autoimmune manifestations, allergic reactions, lymphoproliferation, and increased susceptibility to malignant transformation. In the last decades, several genetic alterations affecting B-cell development/maturation have been identified as causative of several forms of PADs, adding important information on the genetic background of PADs, which in turn should lead to a better understanding of these disorders and precise clinical management of affected patients. This review aimed to present a comprehensive overview of the known and potentially involved molecules in the etiology of PADs to elucidate the pathogenesis of these disorders and eventually offer a better prognosis for affected patients.