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关键词： 历史街区活化   肌理保护   建筑分类   “建筑组团”划分防火分区   分类消防措施  

摘要： 为指导各地积极稳妥实施城市更新行动,防止大拆大建,近日,住房和城乡建设部研究起草了《关于在实施城市更新行动中防止大拆大建问题的通知》。通知提出,在“坚持应留尽留,全力保持城市记忆”方面,要求保留利用既有建筑,保持老城格局尺度,延续城市特色风貌。对此,在符合市场经济规律的背景下,基于以保护历史肌理为底线的规划原则下,本文以佛山旧城的文化商业街区为实践案例研究,提出以“建筑组团”方式划分防火分区,通过多种消防构造设置来满足分区间的建筑消防间距要求,同时对保护建筑进行有效防火隔离,可对街巷的肌理和文物建筑的价值实现最大化的保护。

关键词： 城市阳台   城市滨水区   生态设计   雨洪调蓄   生态净水   亲水   立体游憩  

摘要： 滨水区城市阳台同时具备生态重要性、高游憩需求、城市形象展示等多种功能诉求。在生态文明背景下,秉承长江“生态优先、绿色发展”的理念,南京市江北新区核心区城市阳台的设计提出了兼顾雨洪调蓄、净化等生态系统服务功能与构建多层次游憩网络的设计方法,可为滨水区城市阳台设计提供参考。

关键词： 天涯共此时   月亮   阳台  

摘要： 1.授命9月21日夜,中秋,月亮悬于天际。海上生明月,天涯共此时。已经晚上11点多,阳台上坐了一会儿,与妻说了一些闲话,就准备睡了,毕竟明天又要上班了。

关键词： 西域都护府   乌拉泊古城   轮台   访古   功能分区  

摘要： 新疆历史上有两个轮台。一个是汉轮台,即西域都护府所在地乌垒城,现在巴州轮台县境内。另一个是唐轮台,即现在的乌拉泊古城,地处乌鲁木齐市南郊。周日的上午,艳阳高照,秋色初显,我们登临唐轮台故城。夯土筑成的城墙历历在目,虽然断壁残垣,但依然气势磅礴,风骨凛凛。城垣基本呈正方形,边长各里许。大城之内又划分为三个小城,作为不同的功能分区。

摘要： Purpose/Objective(s) We investigated the efficacy of a combination of radiotherapy with antigen-capturing nanoparticles (AC-NPs; 123 ± 45 nm) containing digitoxin and anti-PODXL siRNA encapsulated in nanocapsules (567 ± 38 nm) that release their contents upon radiation exposure. We performed two radiotherapy sessions. Treatment with AC-NPs achieved successful immuno-radiotherapeutic effects on the primary tumors. An abscopal effect was also observed in the metastatic tumors by dendritic cell (DC)-mediated T-cell priming with PD-L1 blockade. New metastasis reduction was achieved by the dissociation of circulating tumor cell (CTC)-clusters by digitoxin and by reducing the extravasation of the dissociated CTCs via siRNA-mediated silencing of PODXL. Materials/Methods For session 1; nanocapsules were generated by mixing iopamiron and 400 μg anti-PD-L1 antibody (Ab) with a 1.0 mL solution containing 4.0% alginate, 3.0% hyaluronate, and 1 µg/mL P-selectin. This mixture was sprayed into 0.5 mmol/l FeCl2 supplemented with 1 µg/mL anti-VEGFR-1/2 Ab. For session two, 400 nM digitoxin and 50 nM anti-PODXL siRNA were encapsulated in poly lactic-co-glycolic acid (PLGA) AC-NPs using the nanoprecipitation method. The particles were mixed with the above cocktail and sprayed into 0.5 mM/L FeCl2 with 1 µg/mL anti-P-selectin Ab. This yielded encapsulated PLGA AC-NPs containing digitoxin. In session 1; 1 × 1010 nanocapsules were intravenously injected in BALB/c mice exhibiting primary 4TI mammary carcinoma in the left hind leg and lung metastases. Tumor accumulation was monitored using CT imaging. Subsequently, 10/20 Gy 60 Co γ-radiation was locally administered to the primary tumors. In session 2; 1 × 1010 nanocapsules were intravenously injected and allowed to interact with P-selectin for 9 h; 10/20 Gy 60 Co γ-radiation was locally administered. Results In session 1, CT revealed the accumulation of anti-VEGFR-1/2 nanocapsules around the primary and metastatic tumors. The microcapsules

关键词： Resonant waveguide grating biosensor   Real-time kinetics   Cell-based assay   Label-free   Primary human lymphoid cells   Activated and resting immune cells  

摘要： Today, there is an intense demand for lab-on-a-chip and tissue-on-a-chip applications in basic cell biological research and medical diagnostics. A particular challenge is the implementation of advanced biosensor techniques in point-of-care testing utilizing human primary cells. In this study, a resonant waveguide grating (RWG)-based label-free optical biosensor technique has been applied for real-time monitoring of the integrated responses of primary human tonsillar B cells initiated by B cell receptor (BCR) and modified by Fc gamma RIIb and CR1 engagement. The BCR-triggered biosensor responses of resting and activated B cells were revealed to be specific and dose dependent, in some cases with strong donor dependency. Targeted inhibition of Syk attenuated the label-free biosensor response upon BCR stimulation. Indifferent protein human serum albumin (HSA) did not interfere with the recorded signal to BCR stimulation. Simultaneous engagement of BCR and Fc gamma RIIb modulated the kinetic signal of the cells. Activated and resting B cells exhibited different response profiles upon simultaneous engagement of BCR and CR1. This advanced approach has the potential to decipher interfering signaling events in human B cells, manage differences between activated and resting B cell states, helping to understand the actual integrated response of these immune cells, and could be useful in the point-of-care diagnostic testing on human primary cells.

关键词： 高速公路桥梁   伸缩缝维护   问题改善  

摘要： 为探究高速公路桥梁伸缩缝维护工作问题和改善方案,研究伸缩缝的常见类型和主要成因,提出高速公路桥梁伸缩缝维护技术要点,并结合某沿海高速公路桥梁伸缩缝治理工程实例,研究伸缩缝类型表现及发生原因,提出伸缩缝快速修补办法和沿海高速公路桥梁养护办法,供同类工程参考。

关键词： 阳台   背书   发条  

摘要： 严诤从阳台进来时,我正睁开惺忪睡眼。他推开门的瞬间,一股冷风灌进来,我急着叫:“赶快关门,冷死了!”严诤笑着说:“大懒虫,还不起床,太阳都出来了。”我在床上硬是再赖了几分钟床才恋恋不舍地离开温暖的被窝。我打心底佩服严诤,这家伙身体里像安装了定时发条,每天早上,一到五点半就会准时醒来,然后到阳台上背书。