摘要：
Purpose/Objective(s) Among patients (pts) with brain metastases (BM), the population of pts with cystic brain metastases (CBM) is poorly described. CBM present unique treatment dilemmas for symptom and disease control. We aimed to better describe the characteristics and treatment outcomes of these pts. Materials/Methods We retrospectively analyzed medical records of all pts diagnosed with BM and referred to radiotherapy (RT) at our institution between August 2017 and June 2020. We included pts with at least one CBM, defined as a ring enhancing lesion, comprising at least 50% of the diagnosed lesion with a diameter > 0.5cm. We excluded pts previously treated with brain RT and those with leptomeningeal disease. The largest cystic lesion was chosen as the target lesion for assessment. Results Of 452 pts with BM referred to RT, 121 (26.7%) had CBM according to our aforementioned definition. Among pts with CBM, NSCLC (55.4%) and breast cancer (13.2%) were the most common primaries. 72.7% were diagnosed synchronously with the diagnosis of metastatic disease. Symptomatic disease led to diagnosis in 71.1% of cases. 51 pts (42.1%) underwent surgery prior to RT while 63 (52.1%) received RT alone. When comparing the two groups, surgical pts had higher rates of symptomatic BM (86.3% vs. 61.9%, P = 0.004), fewer BM and larger maximal lesion diameter. 12 pts were not treated with RT and excluded from the survival and response analysis. Non-focal RT (whole brain or posterior fossa RT) was delivered to 37.6% and focal RT (radiosurgery or fractionated RT) to 62.4%. Focal RT pts had better performance status (PS), improved control of systemic disease and fewer BM (median – 2 vs. 5 lesions, P < 0.001). Median survival (MS) in the treated cohort was 17 months. 1-year and 2-year survival rates were 60.7% and 40.9%, respectively. Survival significantly improved with PS, younger age, fewer BM and upfront surgery (MS-not reached vs. 13.6mo, P = 0.03). RT method did not significantly affe
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中文科技期刊
国家哲学社会科学学术...
