摘要：
We have previously demonstrated familial dysfunction of C5 in humans, and successful therapy of same with fresh plasma. Leiner, in 1908, suggested changing the wet nurse or substituting bottle feeding. We have therefore, measured functional C5 activity in human, cow, goat, lamb, proprietary and soy milks. A previously described assay of yeast opsonization, which requires normal function of the first five complement components was utilized. Ability of the various milks to restore opsonic activity to two separate C5 deficient serums-human and B10D2 old line mouse-was measured. Confirmation that only C5 activity was being measured was obtained by a)comparing results with those obtained by addition of purified human complement components (As little as 1.5ug/*** C5 will fully restore opsonic activity to C5 deficient serums);b)inhibition of opsonic restoration of the milks with highly purified anti-C5 but not with anti-C3. The data showed that all preparations tested, including soy milk had significant functional C5 activity. We conclude:1)Sources other than plasma may serve in recovery of C5 and/or therapy of abnormal C5 states;2)Functional activity of C5 lasts far longer in milks than in human plasma; 3)The finding of apparent complement activity in milk without animal protein-i.e., soy milk has obvious major biologic implications.
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