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关键词： 物理化学   思政教育   药学  

摘要： 物理化学是药学的专业基础课,其知识和相关应用已渗透到药学各个领域,课程思政融入教学的各个环节已成为新形势下的迫切任务。将社会主义核心价值观贯穿教学过程,结合优秀传统文化,根据药学专业特点,优化教学内容,革新教学方法,达到培养学生高尚情操、激发浓厚学习兴趣、提高教育教学质量的目的。

关键词： Nanoemulsions   Chitosan films   Transdermal drug delivery  

摘要： Transdermal patches for analgesic purposes are widely used, however, their occlusive characteristics can often cause allergic reactions, irritating contact dermatitis, and allergic contact dermatitis upon extended use. Chitosan is a natural positively charged bioadhesive polysaccharide with several biological properties, being promising templates for sustained and controlled topical or transdermal drug delivery. Methyl salicylate (MS) is a nonsteroidal topical anti-inflammatory drug (NSAID). MS is a lipophilic oily drug commonly found in transdermal patches, being difficult to incorporate into hydrophilic formulations such as Chitosan-based films. Thus, MS is a good candidate to be encapsulated into nanoemulsions (NE). This work reports the formulation development, physical-chemical characterization, and in vitro drug release of NE-loaded Chitosan films formulated with MS, as a novel substitute for transdermal analgesic patches. MS was encapsulated into NE, which were prepared by ultrasonication and presented 29.3 nm +/- 0.1 and PdI 0.167 +/- 0.005. The incorporation of MS into NE prevented phase separation and provided a homogeneous physical blending formulation, as confirmed by FTIR, TGA. NE-loaded films provided high drug incorporation in the films 94.08% +/- 6.63%), and a smaller crystallinity degree in comparison with physical mixture films, suggesting a plasticizing effect of nano-sized droplets. Besides, mean weight, thickness, and moisture content were increased in NE-loaded films in comparison with chitosan-based control films. In vitro drug release from NE-loaded films was significantly higher than for physical mixture films, following Weibull and Korsmeyer-Peppas release kinetics models. The results suggest that NE-loaded chitosan film can increase the drug loading capacity of oil drugs and successfully control in vitro release, constituting a novel approach for transdermal drug delivery of NSAIDs. (C) 2020 Elsevier B.V. All rights reserved.

关键词： 物理化学   氧化石墨烯   5,5′-联四唑-1,1′-二氧二羟胺   TKX-50   网络纳米结构   复合含能材料   热分解  

摘要： 为了研究5,5′-联四唑-1,1′-二氧二羟胺(TKX-50)/氧化石墨烯(GO)纳米复合含能材料的热分解性能,采用液氮喷雾冷冻干燥法,制备了TKX-50/GO复合材料;通过扫描电子显微镜-能谱仪(SEM-EDS)、X射线衍射仪(XRD),对样品的形貌、结构以及表面元素含量进行了表征和分析;采用热重-差示扫描量热法(TG-DSC)分析了复合材料的热分解性能;采用Kissinger法计算了其表观活化能。结果表明,采用液氮冷冻喷雾干燥法制备的TKX-50/GO复合材料具有纳米级层状网络结构;与TKX-50相比,TKX-50/GO复合含能材料的第一阶段分解峰峰温向低温方向移动12.0、12.5、12.2℃,第二阶段分解峰峰温向低温方向移动12.5℃和16.4℃,随着GO含量的增加,第二阶段分解峰变得不明显,TKX-50/GO5两个分解阶段重叠,表观活化能从146.2kJ/mol提高到163.3、168.5和172.9kJ/mol。GO提高了复合含能材料的活化能垒,使分解峰温提前,缩短了反应区间时间,从而提高了能量释放速率,促进了TKX-50/GO复合材料的热分解。

关键词： beta-Lactoglobulin   Gum arabic   D-Limonene emulsion   Physicochemical stability   UHT processability   Antimicrobial efficiency  

摘要： The objectives of the present work were to investigate the influence of Gum Arabic (GA) on the physicochemical properties and ultra-high temperature (UHT) processability of beta-lactoglobulin(beta-lg)-stabilized D-limonene emulsions. Moreover, we also wanted to evaluate the antimicrobial efficiency and mechanism of beta-lg-GA bilayer D-limonene emulsions. Physicochemically stable bilayer emulsions could be formed with an optimal concentration of GA (1.00 wt%), which showed a higher tolerance to both flocculation and coalescence, as well as better protective effects on D-limonene against UHT-treatment that up to 94.32% of D-limonene was retained in emulsions. Likewise, it is also noteworthy that no obvious difference in the minimal inhibitory concentration could be found between bilayer emulsions with or without UHT processing. Moreover, the antimicrobial effects of the bilayer emulsions with UHT treatment were shown to be dose-dependent, which was evidenced from the results of scanning electron microscopy and the determination of released cell constituents.

关键词： Cationic   Anionic   Dithiocarbamate chitosan   pH tunable   Adsorption coupled reduction   Sulfur functionality  

摘要： Over the past, extensive works executed to treat anionic and cationic heavy metal ions from wastewater. Although very few adsorbents were developed to adsorb anionic and cationic heavy metal ions from the same system. In this study, we explored the pH tunable complete reduction plus adsorption mechanism of Pb2+ and Cr2O72- by dithiocarbamate-based composite. The pH study recommended that;adsorption of Pb2+ occurred at pH 5.5, besides Cr2O72- reduction coupled adsorption executed at pH 3. Furthermore, quick adsorption occurred within 60 min with adsorption capacities of 228.69 and 219.75 mg g(-1) for Pb2+ and Cr2O72-, respectively. Adsorption isotherm well described by the Redlich-Peterson model, also adsorption processes were fitted by pseudo-second-order kinetics model. Interestingly, characteristic techniques, a physical monolayer model and thermodynamic models were applied to the experimental results to further understand the adsorption mechanisms. The results indicated that the physical model with two types of interaction energies was more appropriate to interpret the adsorption mechanism. Based on the physical model, three thermodynamic functions were calculated and interpreted to attribute new macroscopic interpretations at the molecular level of the adsorption systems. Inspiringly, the metal-composite system highly effective for 5 regeneration cycles and fixed bed column could decontaminate 17.2 L similar to 10 mg L-1 Pb2+ and 7.3 L similar to 10 mg L-1 Cr2O72- to the EPA's wastewater discharge limit by 5 g of CSC@SDBC with the yielding of 400 and 346 mL of eluent, respectively. Theoretically, a liter of CSC@SDBC column may efficiently adsorb 145,646 mg of Pb2+ and 57,518 mg of Cr2O72- from industrial effluent, these were calculated from the Bohart-Adams model. These collective batch and fixed-bed systems were cost-effective and environmentally tolerable techniques to remove anionic and ca-tionic heavy metal ions from industrial wastewater.

关键词： 无机非金属材料物理化学   CAI系统   多媒体   计算机技术  

摘要： 无机非金属材料物理化学课程教学的内容繁杂、难度巨大。因此,进行C A I系统开发辅助教学十分重要,本文分析了CAI系统的特点,阐述了开发无机非金属材料物理化学CAI系统的意义,并从设计系统组成部分、收集准备系统素材、使用多种媒体软件这三方面分析CAI系统的设计开发工作。

关键词： 物理化学   热力学   教学  

摘要： 物理化学是化学的最重要的基础学科之一,是化学、化工、材料、制药、食品、和环境工程等专业的一门重要的专业基础课。本文主要总结了不同条件下物理化学热力学理论中的一些热力学函数的计算公式的应用,以帮助学生更好的掌握公式的应用,培养学生学习归纳的能力,逻辑思维能力和创新思维能力。

关键词： 物理化学   雨课堂   教学改革  

摘要： 物理化学是工科院校工科专业最重要的四大基础课之一,对培养学生各方面能力有很重要的作用。传统的物理化学教学是教师主讲,讲解过程虽细致,但由于公式繁多,学生对学习的积极性不高。本文基于雨课堂,采用"打卡通关式"教学模式,使传统课堂教学多样化,提高了学生学习兴趣,取得了较好的教学效果。

关键词： 课程思政   物理化学   教学改革  

摘要： "课程思政"是当前专业课程教学改革的重要内容。本文以物理化学课程教学为例,对课程思政开展了相关的探索与实践。通过对思政内涵的深入学习,提出在物理化学课程学习中引入化学史,在课程内容上深入挖掘思政元素,润物无声、潜移默化地将程思政元素与专业知识有机融合。在教学过程中借助智慧教学平台更加便捷有效地实现课程思政。本研究可为坚持全课程育人,深化课程思政改革提供参考。

关键词： 材料科学与工程专业   课程群建设   创新人才培养   自主学习   教学模式  

摘要： 该文笔者所在院校研究生材料科学与工程专业拥有无机非金属、金属及加工三个特色方向,均设置了相关的材料物理化学课程。为了适应学科发展不断深入的要求,对原有课程设置的重复性以及协调性不足的情况做了探索性改变。通过各个课程间的统一和融合,整合学科优势师资力量,实现优质师资资源效益最大化,提高教学质量。同时有效提高教师教学效率并强化学生的自主学习能力,促进和激发学生的创新能力。