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关键词： Upper-Division Undergraduate   Physical Chemistry   Hands-On Learning/Manipulatives   Spectroscopy  

摘要： Few laboratory exercises exist that introduce undergraduate students to both the concepts and instrumentation used in rotational spectroscopy. Because of this gap in undergraduate laboratory training, a teaching laboratory for the pure rotational spectroscopy of benzonitrile has been developed and reported. Owing to benzonitrile's recent discovery in space, the molecular spectroscopic technique and target are applicable to both the physical chemistry and astronomy disciplines. Because of the size of the dipole moment and relative safety of the molecule chosen, the laboratory approach allows undergraduates to directly load, tune, measure, and assign spectra using the same quantum chemical approaches and spectroscopic assigning tools available to a researcher in the field. Concepts taught in this laboratory include the rigid and semirigid rotor, as well as low-level nuclear electric quadrupole coupling Hamiltonians. To minimize the budget and allow the students to get hands-on training with the rotational spectroscopy instrumentation, an interactive, low-cost, Balle-Flygare-type, cavity Fourier transform microwave (FTMW) spectrometer of research-grade quality was developed and is reported. Implementation of the laboratory exercise, time of exercise, and student response to the exercise is also reported.

关键词： Triticum aestivum   chitosan   cytocompatibility   antimicrobial   cross linking  

摘要： Polymeric films for various biomedical applications require to be biocompatible and non- toxic. Chemical route of modifications for functionalization of the films for improved properties lead to undesirable effects for biological applications. Hence a natural way to enhancing their properties is by functionalizing them using plant extracts. This report investigates the synthesis of bioactive phytochemical loaded polymer using Triticum aestivum (wheatgrass) extract incorporated in tripolyphosphate crosslinked chitosan. Physical and mechanical properties of the extract functionalized crosslinked chitosan were analyzed and this showed significant changes in thickness, tensile strength and % elongation of the blend. The extract functionalized chitosan was characterized using Fourier transform infrared spectroscopy (FT-IR), Scanning electron microscopy (SEM) and Energy dispersive spectroscopy (EDAX) confirming the interaction between the functional moieties of the extract and polymer. Antimicrobial analysis showed improved activity against Escherichia coli and Staphylococus aureus and Candida albicans. Presence of the extract in crosslinked chitosan enhanced the cytocompatibility in 3T3 cells carried out by MTT assay and showed improved cell migration properties determined by scratch assay. Communicated by Ramaswamy H. Sarma

关键词： Cocrystals   lornoxicam   intrinsic dissolution rate   tabletability   in    vitro dissolution  

摘要： Objective The present study was aimed to prepare and characterize new cocrystals of lornoxicam (LORX), a BCS class II drug employing 1,3-dimethyl urea (DMU) as a coformer to improve physicochemical, pharmaceutical, and pharmacokinetic performance. Methods A screening study was conducted by employing three techniques viz. neat grinding, liquid-assisted grinding (LAG), and solvent evaporation (SE) using different drug-coformer molar ratios (1:1, 1:2, and 1:3). Samples were characterized by DSC, PXRD, ATR-FTIR, SEM, intrinsic dissolution rate (IDR) studies, compressional studies, and pharmacokinetic studies. In vitro dissolution and stability studies (25 degrees C/60%RH and 40 degrees C/75%RH for three months) were carried out for cocrystal tablets. Results LAG and SE were found successful in ratio 1:3 and IDR showed approximately 28- and 19-fold increase, respectively in 0.1 N HCl (pH 1.2) and buffer (pH 7.4) as compared to pure LORX. The cocrystal exhibited good tabletability and was similar to 2.5 times that of LORX at 6000 Psi. Dissolution profiles of tablets of cocrystal increased (56% and 100% at pH 1.2 and 7.4, respectively in contrast to those of physical mixture (PhyMix) (similar to 35% and similar to 10%) and pure LORX (similar to 17% and similar to 7%) within 60 min. The C-max and AUC(0-infinity) for the selected cocrystal were significantly increased (p < 0.05) which was 2.4 and 2.5 times, respectively, that of LORX in a single dose oral pharmacokinetic study executed in rabbits. Tablets of cocrystal were found stable at both conditions. Conclusion The study indicates that cocrystallization with DMU can concomitantly improve tabletability, dissolution rate, and in vivo performance of dissolution limited drug LORX.

关键词： 微课   物理化学   中药学   教学模式  

摘要： 微课作为信息化技术与教育深度融合的重要教学方式之一,以其内容紧凑饱满、逻辑清晰严密、学习方便快捷的优点,得到了高校工作者的广泛关注。本文基于中药学专业物理化学教学过程中普遍存在的“教师难教、学生难学”现象,在探讨中药学专业物理化学教学中存在问题的基础上,将微课与中药学专业物理化学传统教学模式有机结合,突破传统教学模式壁垒,为提升教学效果提供参考。

关键词： 物理化学   课程思政   教学改革  

摘要： 在推进新时代思想政治工作改革攻坚时期,课程思政创新改革也在逐步推进。项目组结合化学专业基础必修课物理化学的课程思政优质课程改革,探讨了物理化学知识体系中的思政元素,介绍了物理化学课程思政教学改革的具体措施和特色。初步改革效果表明,物理化学课程思政创新改革可以促进物理化学教学、提高教学效果和加强学生的思想政治修养。

关键词： DNA结合蛋白   物理化学性质   图形表示法   特征选择   支持向量机  

摘要： DNA结合蛋白在细胞内外的各种活动中起着重要作用。本文提出一种新的DNA结合蛋白预测方法(grDNA-Prot),使用20个氨基酸组成频率和基于AAindex数据库531个氨基酸物理化学性质的图形表示法描述蛋白质序列信息。此外,还采用三种特征选择方法来选择最优特征,并通过5折交叉验证,建立了基于支持向量机的DNA结合蛋白识别预测模型。为验证该方法的有效性,本文在独立测试数据集上与其他方法进行了比较。这些结果表明,Hydrophobicity (H)、Physicochemical properties (P)和Alpha and turn properties (A)是有效区分DNA结合蛋白和非DNA结合蛋白的主要氨基酸物理化学性质。

关键词： 新冠肺炎   中国传统文化   物理化学   教学设计  

摘要： 2020年新冠肺炎引发的疫情在全球蔓延。不同文化和观念在这场疫情中不断发生碰撞和交流,也引发人们对价值观的重新考量。在人类命运联系空前紧密的时代,在传统价值体系遭受争议和考验的时刻,文章立足于物理化学这门专业基础核心课程,围绕如何在大学课堂教学中贯穿社会主义核心价值观和中华文化的优秀传统,进行了深入的反思,并对课程模式进行了探讨。

关键词： 环境   物理化学   教学   改革  

摘要： 物理化学课程作为环境类课程中的一门基础课,在培养环境类人才、解决环境问题中发挥着至关重要的作用.因此,顺应环境类物理化学的课程特点,针对其教学现状中的不足进行改革十分必要.在进行课程教学时,教师应注意知识的连贯性与各章节间的衔接,教学与科研实践的结合,该课程与环境类其他课程的交叉及教学方法的改革.在进行课程学习时,学生应端正学习态度,紧跟课程进度,课后多做习题,并结合实际巩固提升.通过教学实践,在考核制度改革方面可安排小型测试、设置综合实践与期末测试.通过以上改革,使环境类物理化学课程在培养环境类人才、解决环境问题中更好地发挥作用.

关键词： 物理化学AISEC   项目教学   分析和改进  

摘要： 本文设计了ISEC物理化学翻转课堂教学模式,并就考核点小组项目环节进行了设置和分析。对化学工程与工艺专业ISEC物理化学教学过程中,项目部分的分数、对应大纲位置、考核方法和细则、结果分析和项目改进。为进一步探索和提高ISEC物理化学教学水平提供了相应的参考和经验。

关键词： 物理化学   MOOC   课程思政   三阶段教学模式  

摘要： 为实现全方位育人目标,借助MOOC教学新阵地,积极挖掘物理化学课程中蕴含的思政元素,对物理化学MOOC课程思政进行了探索和实践。文中列举了物理化学与哲学思维、走近化学家、赏古诗学物化、学物化倡环保等课程思政的实例并实践了"导学-研学-思学"三阶段物理化学MOOC课程思政教学新模式,从而促进学生思想道德和课程教学质量的全面提升。