关键词:
Cholera infection
Waning vaccine-induced immunity
Lyapunov function
Global stability
Optimal control
摘要:
In this paper, a cholera infection model with vaccination strategy is investigated. By analyzing corresponding characteristic equations, the local stability of each of feasible equilibria is established. By means of Lyapunov functions and LaSalle's invariance principle, it is proved that if the basic reproduction number is less than unity, the disease-free equilibrium is globally asymptotically stable. If the basic reproduction number is greater than unity, the endemic equilibrium is globally asymptotically stable. In addition, by using Pontryagin's maximum principle, several reasonable optimal control strategies are suggested to the prevention and control of the cholera infection. Numerical simulations are carried out to illustrate the theoretical results. (C) 2019 Elsevier Inc. All rights reserved.