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关键词： Andrographolide   Swine flu   Molecular docking   Molecular interaction   Influenza A virus  

摘要： Objective To find new bioactive molecules for the treatment of swine flu. Methods The present study is an attempt to elucidate inhibition potential of andrographolide and its derivatives along with an associated binding mechanism through virtual screening and molecular docking simulation studies. Results Our findings revealed structural conformation changes in 150 loop, secondary sialic acid binding site residues of ACZ97474 {Neuraminidase (A/Blore/NIV236/2009(H1N1)}. Andrographolide have been identified as the highest binging energy of −10.88 Kcal/mol, 3 hydrogen bond interactions (Arg152, Lys150, and Gly197), total intermolecular energy of −12.07 Kcal/mol with bioactivity value (Ki) of 10.59 nmol/L, while the Food and Drug Admistraton approved drug Oseltamivir and Zanamivir have shown 2 and 4 hydrogen bond interactions with binding energies of −6.28 Kcal/mol and −7.73Kcal/mol, respectively, which is higher than andrographolide. The guanidine group of Arg152 has binding affinities to the hydrophilic nature of the inhibitors (-OH and =O groups), as identified by docking of andrographolide (CID: 5318517) on neuraminidase. Conclusions Hence, andrographolide has the potential to inhibit neuraminidase activity of H1N1 and may be used as an alternative medicinal therapy for swine flu positive patient. With potent antiviral activity and a potentially new mechanism of action, andrographolide may warrant further evaluation as a possible therapy for influenza.

关键词： 壮族麽经布洛陀影印译注   造物神话   文学地理学   民族民间文学   少数民族文献  

摘要： 文学地理学以文学为核心,关注文学中的“人-地”关系.民族民间文学深植于风土民情土壤,地理因素不仅是民族文化发生和发展的根基,也是民间文学内容的主要构成.《壮族麽经布洛陀影印译注》中的造物神话以民众熟悉的自然意象来解释周遭事物来源,传达了壮族人民之于自然世界的态度,“敬天格物”理念贯串于整个“天→人→文学→人→天”的认知循环中,充分显现着壮民族整体性的天人和谐的生态哲学.

关键词： 陈学霖   北京建城   传说   民俗学  

摘要： 陈学霖关于北京建城传说的研究几乎贯穿其学术生涯,并取得了重要的研究成果。他对北京建城传说的研究以大小传统说为理论依据,在史学的框架内进行了分析,进一步印证和阐发了流行的民俗学理论,对加深认识元明史事与人物、对近代民间信仰与传说发展具有重要意义,同时也是史学研究的新角度和新探索。

关键词： 民俗   语境   田野研究   关键词  

摘要： 中国民俗学者自上世纪90年代起,将民俗学的研究视角转向语境中考察民俗,呈立体性的整体研究取向,使得"语境"成为民俗学研究、特别是民俗学田野研究的一个关键词。文章通过从语境问题的讨论史、语境与民俗学研究的关系、语境概念及其系统等议题入手,对民俗学田野研究中的语境构成要素及其分类作细致考察。

关键词： 投稿须知   贵州民族研究   综合性学术期刊   民族语言文字   民族民间文学   民族学   学术论文   学术价值  

摘要： 《贵州民族研究》是民族学类综合性学术期刊，主要刊载具有较高学术价值的学术论文，辟有民族工作、民族理论、民族经济、民族教育、民族历史、民族学、民族风俗、民族语言文字、民族民间文学、调查研究、民族学研究介绍等栏目。

关键词： 民俗学研究   对象和边界   学科独立性   合法性  

摘要： 民俗学研究的对象和边界是我国民俗学自身发展中一个重要的理论问题,如何认识和厘清这个问题关系到民俗学学科存在的合理性和独立性。本文侧重比较各国民俗学界关于民俗学研究的对象和边界这两个基础问题的认知历史,明确"民众日常生活中反复出现的传承性的生活文化"是民俗学研究对象和边界的核心内容,进一步讨论民俗学自身研究对象存在的不确定性及其形成原因,对由此引发的当下关于民俗学学科独立性的忧虑、疑惑作出回应,认为民俗学研究在其研究对象和边界的基本问题已明确的基础上应有其开放性立场和现代眼光。

关键词： 民俗学   教学改革   创新  

摘要： 本文针对高校民俗学课程,为了增强民俗学教学的效果,笔者对民俗学教学现状进行了研究分析,并提出了改进教学的建议。希望本文能够对国内高校民俗学课程教学改革起到抛砖引玉的作用。

关键词： 家仙   小碧头   田氏家族(南方)   民俗学  

摘要： 本文阐述了“安家仙”，俗称“安家神”的发展历程及南、北方的差别。以湖南省怀化市辰溪县孝坪镇杉坳村第10组小碧头为主要地域，小碧头田氏家族为主要群体，围绕“家仙”这一历史悠久的祭祀习俗开展调查。

关键词： Folklore   Folk culture   Folk literature   Travelogues   Maps   Travel   Walking   Field research  

摘要： Folk culture was a key concept and source of inspiration for the national romantic movement. This was decidedly the case in the Nordic countries, where folklore texts documented by folklore collectors, stored in large archives, and published in academic publications became intrinsically connected with the promotion of national identity. Additionally, in this article, I propose that folklore collectors' actual travels and physical presence may have significantly contributed to this process. Taking as a starting point Maurice Merleau-Ponty's (1962) contention that our bodily experience of movement provides us with a way of accessing the world, I argue that bodies in motion can have an integral role in the creation and performance of identities. Based on travelogues kept by nineteenth-century and early twentieth-century folklore collectors in Swedish-speaking Finland, I also reflect on the physicality of the fieldwork situation and the importance of bodily techniques.

关键词： FOLKLORE   SWEDEN   FINLAND  

摘要： In the fall of 2011, Indiana University hosted the annual meeting of the American Folklore Society. For three days in October, scholars gathered in Bloomington to celebrate the dynamic breadth of folklore on a campus that has been the home for the serious study of folklore for over sixty years. As a faculty member in the Folklore Institute, I was asked to serve as discussant for a panel on embodying Nordic spaces. Two of those papers are part of this volume; two more papers have been added since, and I read them now for the first time. The Journal of Folklore Research has a long history of publishing international folklore scholarship, and we continue that service with this volume on northern Europe. The four papers presented here add a diversity of voices—both of scholars and informants—and present new topics within familiar folklore genres, exposing readers in the United States and abroad to the concerns and approaches of contemporary scholars in northern Europe today.