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关键词： 无机化学   化学实验   分析化学  

ISBN: (纸本)9787548229230

摘要： 本书分为无机及分析化学实验基础知识，化学实验基本操作，化学原理、元素性质与物理量少测定，分析化学实验，综合和设计性实验五部分，内容包括：化学实验规则、实验室安全知识、实验数据处理、试剂的取胜和试管操作、滴定操作练习、酸碱平衡和沉淀平衡等。

关键词： proteomics   cross-linking   mass spectrometry   protein structure  

摘要： Protein chemical cross-linking and mass spectrometry enable the analysis of protein protein interactions and protein topologies;, however, complicated cross-linked peptide spectra require specialized algorithms to identify interacting sites. The Kojak cross-linking software application is a new, efficient approach to identify cross-linked peptides, enabling large-scale analysis of protein protein interactions by chemical cross-linking techniques. The algorithm integrates spectral processing and scoring schemes adopted from traditional database search algorithms and can identify cross-linked peptides using many different chemical cross-linkers with of without heavy isotope labels. Kojak was used to analyze both novel and existing data sets and was compared to existing cross-linking algorithms. The algorithm provided increased cross-link identifications over existing algorithms and, equally importantly, the results in a fraction Of computational time. The Kojak algorithm is open-source;cross-platform, and freely available. This software provides both existing and new cross-linking researchers alike an effective way to derive additional cross-link identifications from new or existing data sets. For new users, it provides a simple-analytical resource resulting in more cross-link identifications than other Methods.

关键词： Porous membranes   Diamond coating   Ananlytical chemistry   Electrochemistry  

摘要： In this study, novel diamond porous membranes are developed through a reliable process providing a unique pathway toward large surface area and porous materials. Mainly deposited onto flat surface so far, we demonstrate here that diamond coating is possible on very complex 3D shapes, even nanoporous ones, through an original nanoseeding process and adapted growth conditions. Such membranes or filters exhibit outstanding features thanks to the unique mechanical properties and surface chemistry of diamond. Indeed, the straightforward tuning of their surface properties associated to their high stability ensures the diamond porous membranes' applications in the scope of filtration, separation and extraction. Preliminary electrochemical studies highlight the membranes' potential to be used for high specific area electrode applications. After an extensive characterization of these new diamond porous membranes, their potential for protein extraction will be demonstrated through mass spectrometry detection. (C) 2015 Elsevier B.V. All rights reserved.

关键词： Upper-Division Undergraduate   Analytical Chemistry   Inquiry-Based/Discovery Learning   Atomic Spectroscopy   Quantitative Analysis  

摘要： For most chemistry curricula, laboratory-based activities in quantitative and instrumental analysis continue to be an important aspect of student development/training, one that can be more effective if conceptual understanding is delivered through an inquiry-based process relating the material to relevant issues of public interest and student career trajectories. Laboratory experiences that actively engage students in this manner can be difficult to identify and execute. A special topics, project-based laboratory module is presented here that utilizes multiple techniques and instruments to investigate toxic metal content (lead, cadmium, and arsenic) in children's toys and toy jewelry. The module effectively illustrates a considerable number of fundamental and advanced quantitative analysis principles including sample digestion, Beer Lambert law, calibration curve, and standard addition analyses, as well as instrumental analysis considerations of atomic absorption spectroscopy including atomization efficiency (e.g., flames vs furnaces), matrix modifiers, and nondestructive spectroscopy. Module effectiveness stems from the illustration of critical chemical analysis principles in the context of projects with student-directed hypotheses and experimental results that are clearly relevant to the interface of basic science, medicine, and public health: primary career interests for a significant number of undergraduates in the physical and life sciences.

关键词： Upper-Division Undergraduate   Analytical Chemistry   Inquiry-Based/Discovery Learning   Spectroscopy  

摘要： This letter to the editor comments on the paper, "Purity Analysis of the Pharmaceuticals Naproxen and Propranolol: A Guided-Inquiry Laboratory Experiment in the Analytical Chemistry Laboratory".

关键词： Double-sided microfluidic   lab-on-a-chip   iron speciation   green analytical chemistry   natural water  

摘要： Microfluidics minimize the amounts of reagents and generate less waste. While microdevices are commonly single-sided, producing a substrate with microchannels on multiple surfaces would increase their usefulness. Herein, a polymethymethacrylate substrate incorporating microchannel structures on two sides was sandwiched between two polydimethylsiloxane sheets to create a multi-analysis device, which was used for the spectrophotometric analysis of the ferrous ion (Fe2+) and the ferric ion (Fe3+), by utilizing colorimetric detection. To monitor the signals from both channel networks, dual optical sensors were integrated into the system. The linear ranges for Fe2+ and Fe3+ analyses were 0.1- 20 mg (R-2 = 0.9988) and 1.0 - 40 mg L-1 (R-2 = 0.9974), respectively. The detection limits for Fe2+ and Fe3+ were 0.1 and 0.5 mg L-1, respectively. The percent recoveries of Fe2+ and Fe3+ were 93.5 - 104.3 with an RSD < 8%. The microdevice demonstrated capabilities for simultaneous analysis, low waste generation (7.2 mL h(-1)), and high sample throughput (180 h(-1)), making it ideal for greener analytical chemistry applications.

关键词： 模糊综合评价方法   实验教学模式   分析化学   开放式   程序性   化学实验课程   培养目标   设计模式  

摘要： 分析化学实验课程是学科教学体系中的构成要件．对于实现应用性、复合型人才的培养目标，具有极其重要的教育价值．探索了渐进式的开放实验设计模式，即局部开放和完全开放两种，使学生通过基础性实验，提高性实验及应用、创新性实验三个阶段逐渐进入全面发展的状态．通过有益的实践，以期该教学模式在激发学生学习兴趣、培养实践能力、培育创新意识方面具有良好的促进作用以及对化学其它实验课程起到良好的示范和辐射作用．为了评价该教学模式的实施效果，设计了教学评价的定性指标体系，并通过模糊综合评价方法进行运算，得出定量的综合评价结果以评价该教学模式的实施效果[1-4]．

关键词： 分析化学实验   网络   考试系统  

摘要： 本文介绍了分析化学实验网络考试系统的设计策略,以及该系统的体系结构和功能特点。该网络考试系统不仅能满足网络实验考试系统的要求,而且能促进教师的教和学生的学,提高教师的工作效率以及学生的考试积极性,同时也使得分析实验考试更具灵活性。

关键词： 创新人才   培养   分析化学   教学改革  

摘要： 文章选择创新人才培养条件下的分析化学教学改革为本次研究的重点内容,结合笔者实践经验,首先介绍高校分析化学教学制约性因素,再对创新人才培养环境下的分析化学教学改革程序进行深入剖析,期待通过优化分析化学教学改革路径,对日后分析化学教学实践活动的开展提供参考建议。