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关键词： organic chemistry  

摘要： Next generation: Editorial Board Co‐Chair Jian Pei, together with the other Editorial Board members from China, reflects on the interdisciplinary future of organic chemistry and how the young Chinese researchers featured in this issue are making that future reality.

关键词： Second-Year Undergraduate   Graduate Education/Research   Chemical Education Research   Organic Chemistry   Reactions   Mechanisms of Reactions  

摘要： To explore the differences between how organic chemistry students and organic chemistry professors think about organic chemistry reactions, we administered a card sort task to participants with a range of knowledge and experience levels. Beginning students created a variety of categories ranging from structural similarities to process oriented categories. Professors and more experienced graduate students created their categories only for process oriented reasons. Professors discussed different features of the reactions than the students did, suggesting that students need guidance and opportunities to develop skills to identify mechanistically relevant features in a reaction. More specifically, at the University of Ottawa, a transformed organic chemistry curriculum has been designed and implemented where students are first taught the language of mechanisms before learning about specific reactions. Then, students are taught reactions in order of their governing pattern of mechanism, rather than by functional group. We developed a card sort task to investigate how students perceive the organization of the reactions in the curriculum as well as to explore how graduate students and professors think about organic chemistry reactions. There were 25 cards designed with reactants and reagents for reactions taught within the first two semesters of organic chemistry. The card sort task is composed of two parts: first, participants are asked to sort 15 cards into categories;second, the participants are given 10 additional cards and asked to incorporate them into their existing categories. During the fall 2017 semester, second semester organic chemistry students (N = 16), organic chemistry graduate students (N = 10), and professors who either teach and/or conduct research in organic chemistry (N = 7) were interviewed using the card sort task. We analyzed the participants' categories for cards that were frequently sorted together and the reasons they gave for creating the categor

关键词： Second-Year Undergraduate   Upper-Division Undergraduate   Organic Chemistry   Inquiry-Based/Discovery Learning   Kinetics   Reactive Intermediates  

摘要： Acquiring conceptual understanding seems to be one of the main challenges students face when studying organic chemistry. Traditionally, organic chemistry presents an extensive variety of chemical transformations, which often lead students to recall an organic transformation rather than apply conceptual knowledge. Strong surface level focus and rather weak conceptual at knowledge is the consequence. Purposefully designed tasks, which help engaging students to "overlook" the structural features, are proposed here as a means to enhance conceptual understanding and the integration of concepts. Following the idea of contrasting cases, broadly used in science education, and mirroring the epistemic practice of organic chemistry, we illustrate how contrasting cases can be embedded in an inquiry process to highlight the influence of electronic substituent effects on reactive intermediates and rates of organic reactions.

摘要： Carbon monoxide as an example of reducing agent, in contrast to classical reducing agents (hydrogen and metal hydrides), can provide very high atom precision for reductive addition of substrates with various functional groups. This enables synthesis of new compounds with unique structures and properties.

关键词： 饮食健康   生命   基础   有机化学  

摘要： 随着我国社会经济的发展,人们生活水平的提高,对饮食健康也越来越重视。民以食为天,我们的正常生活离不开食物,人体正常代谢需要从食物中摄取相关的营养物质,基础有机化学物质正是维护正常生命活动的重要因素。本文结合饮食健康,来论述学好生命中基础有机化学物质的重要性,为人们的健康饮食提供参考。

关键词： polyoxometalates   post-functionalization   redox chemistry   solvothermal reactions   vanadium  

摘要： We report the synthesis, post-functionalization, and redox behavior of two organically functionalized aggregates, [V6O7(OMe)(9){(OCH2)(3)C-CH2N3}] and [V6O7(OMe)(9){(OCH2)(3)C-NH2}]. All twelve (2)-oxo groups on the edges of the Lindqvist-type {V6O19} core were replaced by alkoxo ligands. The absence of a negative charge and the closed organic shell make these neutral mixed-valence compounds very stable towards hydrolysis and well soluble in almost all common organic solvents. These are important advantages over classical POMs. By post-functionalization through copper(I)-catalyzed Huisgen cycloaddition or imine formation, various organic moieties could be introduced. Even a well-soluble trimer composed of three hexanuclear vanadium units connected through an aromatic triimino core was synthesized and studied. The diverse redox behavior, the versatile reactivity, the good stability, and the excellent solubility make our vanadium compounds highly interesting for applications as building blocks in macromolecular chemistry as well as redox labels in biochemistry.

关键词： Ethers  

摘要： A method for the preparation of aryl alpha,alpha--difluoroethyl thioethers (ArSCF2CH3) is reported and the synthesis approach is extended to aryl alpha,alpha-difluoroethyl oxygen ethers. Selected building blocks are further elaborated in cross-coupling reactions and are incorporated into analogues of established trifluoromethyl ether drugs. Conformations are explored and log P studies of these motifs indicate that they are significantly more polar than their trifluoromethyl ether analogues rendering them attractive for bioactives discovery.

关键词： 有机化学   有机化合物   物质   链   烤面包   碳原子   穿着  

摘要： 不管是这本杂志，还是现在所穿着的棉服与尼龙质地的衣服，抑或今早吃的烤面包，这些都是有机化合物。所谓有机化合物，就是以碳原子（C）为骨架的化合物，我们每天都穿着有机化合物，吃着有机化合物。更重要的是，我们本身就是由有机化合物构成的。