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关键词： Laboratory Instruction   Hands-On Learning/Manipulatives   Second-Year Undergraduate   Amino Acids   Medicinal Chemistry   Synthesis  

摘要： An experiment for the synthesis of N-acyl derivatives of natural amino acids has been developed as part of the Distributed Drug Discovery (D3) program. Students use solid-phase synthesis techniques to complete a three-step, combinatorial synthesis of six products, which are analyzed using LC-MS and NMR spectroscopy. This protocol is suitable for introductory organic laboratory students and has been successfully implemented at multiple academic sites internationally. Accompanying prelab activities introduce students to SciFinder and to medicinal chemistry design principles. Pairing of these activities with the laboratory work provides students an authentic and cohesive research project experience.

关键词： Second-Year Undergraduate   Upper-Division Undergraduate   Organic Chemistry   Laboratory Instruction   Inquiry-Based/Discovery Learning   Collaborative/Cooperative Learning   Reactive Intermediates   Stereochemistry   NMR Spectroscopy   Molecular Modeling  

摘要： A multifaceted experiment, accessible to students either in an introductory organic chemistry course or in a more advanced laboratory setting, is described for investigating the addition of dichlorocarbene to E- and Z-beta-methylstyrenes. The innovative exercise, which integrates elements of synthesis, mechanisms, instrumental analysis, computational chemistry, and collaboration, provides students with an opportunity to learn important laboratory skills while highlighting key concepts covered in class. In particular, the coupling constants from H-1 NMR spectroscopy are used to diagnose the stereochemistry of addition, and integral ratios are evaluated to determine percent conversion of the starting alkenes into dichlorocyclopropanes. The experimental observations are correlated with results from calculations of the singlet-triplet energy gap in the carbene.

关键词： 有机化学   教学方法   能力培养   因材施教  

摘要： 有机化学对于提高学生们的逻辑思维能力和科学素养具有至关重要的意义,本文进行了大量的调查和研究,经过实践总结,对有机化学教学现状进行了充分的分析,探讨了有机化学教学中的高效培养策略,从而鼓励教师因材施教,提高教学质量。同时,需要解决目前教学中的矛盾,调整教学内容,吸引学生的学习兴趣,帮助他们建立自主学习模式,从而更新有机化学教学改革思路,最终培养学生们的创新能力和科学素养。

关键词： 有机化学   重排反应   产生原理  

摘要： 有机化学中的反应有非常多的分类,本文就重排反应这一类,进行了一些浅显的讨论和分析,同时介绍了一些重排反应在材料合成和医药领域的具体应用.

摘要： Highlights from the article: Guest editor Nikolay E. Nifantiev introduces the Institute Feature dedicated to N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences (ZIOC), Moscow. I hope very much that this Special Issue and the described results will attract attention of the large audience of the I European Journal of Organic Chemistry i and will stimulate new contacts and collaborations with laboratories at ZIOC.