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关键词： 氨基酸催化   Aldol反应   创新设计性实验   科研能力  

摘要： 氨基酸催化的不对称Aldol反应是不对称催化领域的一个研究热点,将其转化为设计性创新实验并面向化学院三年级学生开设。通过对反应底物、催化剂、溶剂等不同反应条件的探索,加深学生对手性、烯胺催化等概念、机理的理解,培养学生的科研能力及创新能力。

关键词： 新工科   环境工程专业   有机化学   改革与探索  

摘要： 基于新工科建设背景,针对环境工程专业有机化学课程存在知识点多和课时少等局限,利用建设环境工程领域有机化合物污染治理案例库和“大班授课+小班研讨”教学模式等辅助模式,开展教学与生产实践及科研相结合等课程内容改革的探索与实践,培养学生多维度的创新能力、学习能力及获取能力,并在教学中进行了一系列有意义的尝试,为环境工程专业新工科应用型人才培养提供有益探索。

关键词： 有机化学   农科专业   存在问题   对策  

摘要： 近年来,高校教学改革不断深入,固有的有机化学教学模式已不能满足当前教学的需求。为提高农科专业《有机化学》课程的教学质量,本文结合作者近十年本科有机化学的教学实践,从课程设置的现状、存在问题和原因等方面进行了深入的分析,提出提高课堂教学质量、强化教材建设、加强师资力量建设等对策。

关键词： 有机化学   课堂教学   新课导入  

摘要： 新课的导入是教学过程的开始,良好的课堂导入有助于激发学生的学习热情,提高学生的学习兴趣,从而提高课堂教学效果,因此新课导入要讲究方法和技巧。结合自身从事有机化学教学的实际经验和体会,介绍了有机化学课堂教学导入新课的几种方法,如日常生活导入、化学药物事件导入、社会热点新闻导入、诺贝尔化学奖导入和学生自主导入等,希望给有机化学教师提供一些参考。

关键词： Upper-Division Undergraduate   Problem Solving/Decision Makin&   Biochemistry   Organic Chemistry  

摘要： A chemistry course designed as an elective for chemistry, biochemistry, biology, and pharmaceutical science majors is described. The course is designed for second- through fourth-year undergraduate students. The prerequisite is first-semester, second-year undergraduate organic chemistry with the second semester of the organic sequence as a corequisite. The emphasis is on the mechanistic organic chemistry of enzyme transformations. An inductive approach is utilized in which students are initially taught an array of mechanistic probe experiments and learn how to design and implement these experiments to elucidate mechanisms. The intent of this research/hypothesis-driven approach is to enable students to propose experiments to test premises. After proposing probe experiments, the students will receive data so that, upon their interpretation of the data, they can propose potential mechanism(s) and defend their proposals. The primary chemical literature is emphasized throughout the course. Potential syllabi, a detailed overview of the applicable mechanistic probe experiments, multiple problem sets for distribution to students (with a faculty answer guide), a listing of 40 appropriate primary literature research articles utilized in the course, a listing of additional resources, and an extensive student study guide (reviewing applicable organic chemistry and biochemistry review principles) are all provided in the Supporting Information.

关键词： Organic chemistry   Undergraduates   Students  

关键词： Green Chemistry   Textbooks/Reference Books   Organic Chemistry   General Public   Second-Year Undergraduate  

摘要： This paper examines the current state of the implementation of green chemistry into organic chemistry textbooks. Content analysis of the 15 most used organic chemistry textbooks revealed that only 10 of them had any mention of green chemistry. In textbooks that contained mentions of green chemistry, it was mentioned on less than 1% of pages. Green chemistry topics mentioned include the 12 green chemistry principles, atom economy, greener solvents and reagents, recycling, biodegradable materials, renewable feedstocks, and catalysis. Only three textbooks contained several end-of-chapter problems with green chemistry content, and all but two included the majority of green chemistry content in extraneous textboxes. The current presentation of green chemistry concepts and lack of assessment items is more suitable for a lecture-based approach as opposed to creating a student-centered learning environment.

关键词： First-Year Undergraduate/General   Second-Year Undergraduate   Curriculum   Organic Chemistry   Testing/Assessment   Green Chemistry  

摘要： The American Chemical Society (ACS), Division of Chemical Education, Examinations Institute, has been developing content maps to describe comprehensively the undergraduate curriculum aligned to traditional subdisciplines. These content maps have been developed through the combined efforts of many faculty members who teach the targeted courses in the subdiscipline. A recent collaboration between the Examinations Institute and the ACS Green Chemistry Institute has resulted in the consideration of green chemistry content in the context of the content maps. The inclusion of green chemistry concepts in the context of organic chemistry has been the initial focus of the work of this collaboration. Through working with faculty who teach green chemistry courses or organic chemistry courses with the theme of green chemistry, the organic chemistry content map has been revised and reconceptualized with the theme of green chemistry included. The process, excerpts of the content map, and alignments of traditional organic chemistry exam items to both the organic chemistry content map and the organic chemistry content map with the inclusion of green chemistry are reported.

ISBN: (纸本)9787122357939

关键词： chemoinformatics   combinatorial chemistry   drug discovery   natural products   organic synthesis  

摘要： All pharmaceutical products contain organic molecules;the source may be a natural product or a fully synthetic molecule, or a combination of both. Thus, it follows that organic chemistry underpins both existing and upcoming pharmaceutical products. The reverse relationship has also affected organic synthesis, changing its landscape towards increasingly complex targets. This Review article sets out to give a concise appraisal of this symbiotic relationship between organic chemistry and drug discovery, along with a discussion of the design concepts and highlighting key milestones along the journey. In particular, criteria for a high-quality compound library design enabling efficient virtual navigation of chemical space, as well as rise and fall of concepts for its synthetic exploration (such as combinatorial chemistry;diversity-, biology-, lead-, or fragment-oriented syntheses;and DNA-encoded libraries) are critically surveyed.