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关键词： Organic chemistry   Alcohols   Organic synthesis   Anions   Pharmaceuticals  

关键词： Upper-Division Undergraduate   Second-Year Undergraduate   Organic Chemistry   Constructivism   Mechanisms of Reactions   Computer-Based Learning Assessment  

摘要： The mechanism maps that guide student instruction in organic chemistry curricula are structural representations of bond-breaking and bond-making events that transform a reactant into a product. For students, these pathways represented by electron pushing formalism (EPF) can be challenging to navigate. For instructors, providing formative feedback to students to support their learning of the EPF arrow system is difficult to provide in a timely manner. The Mechanisms App ("the App") was developed as a method for students to explore the electron movement of organic chemistry through a touch screen interface of a smart phone or tablet with real-time feedback of these moves. In this paper, the pedagogical content of the App and its backend system is described. This system produces a graphical record of a user's move within the App and is called a decision tree. A study of students' use of the App in two different modes was devised to understand whether the in-app experience can facilitate a hypothesis- driven approach to learning EPF. Examples of classroom implementation for the App in a variety of institutions and future research are also described.

关键词： High School/Introductory Chemistry   First-Year Undergraduate/General   Organic Chemistry   Testin Assessment  

摘要： A dual-enrollment course was designed in which the elementary concepts of organic chemistry were introduced to high school students. Students were assessed at the end of the term using an American Chemical Society (ACS) standardized exam. The same exam was given to corresponding traditional on-campus sections of the same class taught by the same professor. Intriguingly, when dual-enrollment students' performance was compared with the performance of the traditional on-campus students studying the same content, no statistical difference was detected. Moreover, the dual-enrollment students have scored at a level significantly higher than the nationwide averages advertised by the Examinations Committee of the ACS.

关键词： Positive ions  

摘要： The use of sulfinic acids and their salts continues to be extensively developed in organic chemistry. This is attributable to their dual capacity for acting as nucleophilic or electrophilic reagents, as well as their ease of preparation and stability on storage. This report highlights the research accomplished since 2015 on this topic, updating a previous review published by our team in 2014.

关键词： 命名原则   有机化合物命名   有机化学教学  

摘要： 在对《有机化合物命名原则(2017)》基本原则进行梳理的基础上,对一些调整后的规则进行简化,使其适用于本科有机化学教学中有机化合物的命名。并结合实例,对命名的原则及用法进行说明。

关键词： 科教协同   有机化学   积极性   创新思维能力  

摘要： 科教协同理念已成为当今高校打造教学研究型大学的发展目标,是教学改革发展的重要方向。而在药学专业课程中,有机化学是一门依托教学和科研相结合的基础学科。在课堂教学中引入前沿的科研成果,注重科教协同理念,不仅能够扩宽学生的知识面,还提高学习的积极性以及创新思维能力。本文将结合近几年在药物合成以及药物活性方面的前沿成果,介绍了如何把科研成果融入到有机化学课堂教学中的几点应用实例。

关键词： 有机化学   共晶   3-氨基-4-(四唑-5-基)呋咱   HAFT   EDN   晶体结构   热分析  

摘要： 以3-氨基-4-(四唑-5-基)呋咱(HAFT)和硝酸乙二胺(EDN)为原料,制备得到二元共晶HAFT·EDN,采用X射线衍射仪(XRD)、红外光谱、元素分析和X-射线单晶衍射仪表征了目标物结构;采用差示扫描量热(DSC)对HAFT·EDN共晶进行了热性能测试,并测试了其撞击感度和摩擦感度;通过Kissinger法、Ozawa法和Starink法计算分析了非等温动力学、热爆炸临界温度等性能参数。结果表明,该晶体属于单斜晶系,空间群为P21/c,晶体学参数为:a=7.515(4),b=9.823(5),c=14.828(8),β=86.152(9),V=1092.1(10)3,Dc=1.680g/cm3,其活化能为127.58kJ/mol,热爆炸临界温度为283.7℃,分解反应过程活化熵(ΔS≠)为-44.08kJ/mol,活化焓(ΔH≠)为119.68kJ/mol,吉布斯自由能(ΔG≠)为143.33kJ/mol,具有较好的稳定性,对撞击和摩擦刺激均钝感。