教学课程资源库 更多>>

ISBN: (纸本)9787200126181

关键词： chemometric   hepatotoxic constituent   hepatotoxicity   UPLC fingerprint  

摘要： Evodia rutaecarpa (E. rutaecarpa) has been used to treat aches, vomiting and dysentery in traditional Chinese medicine. However, as a mildly toxic herb its toxic components have not been elucidated. An attempt was made to illuminate the hepatotoxic constituents of E. rutaecarpa. The 50% ethanol extracts of E. rutaecarpa from 19 different sources were used to establish UPLC fingerprints and administered to mice at a dose of 35g/kg (crude medicine weight/mouse weight) once daily for 14days. Serum levels of alanine transaminase, aspartate aminotransferase and liver coefficient were used as indices of liver injury. Additionally, the characteristic peaks of 19 fingerprints were identified. Spectrum-effect relationships between fingerprints and hepatotoxic indicators were analyzed using bivariate correlation analysis (BCA). The UPLC fingerprints were established and a total of 28 main compounds were identified. Because of the inherent variations in chemical compositions, the liver injury levels were different among the E. rutaecarpa samples from 19 sites of production. BCA results indicated that compounds dihydrorutaecarpine, 6-acetoxy-5-epilimonin, goshuyuamide I, 1-methyl-2-[(Z)-5-undecenyl]-4(1H)-quinolone, 1-methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, evocarpine and 1-methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone were tentatively determined as the primary hepatotoxic components. The present study provides a valuable method for the discovery of hepatotoxic constituents by combination of fingerprints and hepatotoxicity index.

关键词： 祭祀   戏剧研究   中国  

ISBN: (纸本)9787503962318

摘要： 本书是研究“祭祀戏剧”的专著，作者在全面总结当下学界同仁的相关成果的基础上，做了颇有价值的独立学术思考，从祭祀戏剧的概念界定、研究范畴、祭祀戏剧的源流、祭祀戏剧的地域特色、祭祀戏剧的展演形态和展演场所、祭祀戏剧与文人戏剧等角度对民间“祭祀戏剧”做了系统性的理论研究，概括的民间祭祀戏剧形态各异、细节丰富，令人耳目一新。作者在跨学科思考的同时，提供了中国“祭祀戏剧”和“仪式戏剧”的模版，对戏剧史学科有着开拓与创新的意义。

关键词： 吴茱萸碱   柠檬苦素   有效成分含量   活性成分   盐制   甘草汁  

摘要： 吴茱萸别名吴萸、茶辣等,在我国分布广泛。具有镇痛、抗炎、抗肿瘤、抗菌的功效,主要有效成分为吴茱萸碱、吴茱萸次碱和柠檬苦素。中药吴茱萸是以炮制品入药,盐制吴茱萸也是常用的炮制方法。本文采用RP-HPLC法,测定盐制吴茱萸炮制过程中吴茱萸碱、柠檬苦素、吴茱萸次碱的含量和动态变化。结果表明,3种有效成分含量在不同的炮制条件下有明显差异,且呈现出一定规律。

关键词： 吴茱萸   涌泉穴   眩晕  

摘要： 目的:探讨吴茱萸贴敷涌泉穴治疗眩晕的临床观察。方法:72例眩晕患者,随机分为治疗组和对照组,各36例。治疗组采用吴茱萸醋调贴敷双侧足底涌泉穴联合口服尼莫地平治疗,对照组口服尼莫地平治疗,观察两组患者的临床疗效。结果:两组患者经过2个疗程治疗,治疗组总有效率为94.4%,明显高于对照组的72.2%,差异有统计学意义(P<0.05)。结论:吴茱萸外敷涌泉对眩晕在消除临床症状,改善椎-基底动脉供血等方面有较好疗效,可起到标本兼治的作用。