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关键词： Catalysis  

摘要： The conversion and upgrading of biomass-derived platform molecules are essential for achieving high-value utilization of biomass. This review firstly introduces the constituents of biomass and various pretreatment technologies, and further elaborates on the research progress of biomass catalytic conversion, especially the applications and advantages of homogeneous catalytic and heterogeneous catalytic conversion systems as well as different solvent catalytic conversion systems, covering their contributions to the improvement of conversion and selectivity of the target products. Secondly, the properties, generation pathways, and current research progress of several typical biomass-derived platform molecules are summarized, and their potential applications in high-value-added products such as fuels and chemicals are briefly assessed. Finally, by summarizing the current research status, it points out several challenges in the conversion of biomass-derived platform molecules, such as the unclear catalytic reaction mechanism, the need to improve the selectivity and stability of the catalysts, as well as the high cost of the catalysts. And a brief look at its future direction is given. © 2025 Chemical Industry Press Co., Ltd.. All rights reserved.

关键词： Chemical industry  

摘要： This paper conducts a comparative analysis of the current status and developmental trends in bio-based material technologies and industrial ecosystems between domestic and international contexts. It summarizes the enlightenment derived from the advancement of global bio-based material industries, while systematically analyzing existing challenges within China’s bio-based material from both policy frameworks and industrial development perspectives. Taking the advancement of carbon peak and carbon neutrality as the fundamental objectives for developing bio-based materials, and considering the diversity in raw material sources, product portfolios, and technological pathways for bio-based materials, six guiding principles for prioritizing bio-based material products development and selecting technological routes in China are established. The study specifically proposes bio-based polyethylene as a strategic focal point for China’s bio-based material industry advancement, accompanied by three key recommendations: ①Expedite breakthroughs in core technologies to establish a mature and advanced technological chain;② Cultivate a stable and reliable raw material supply chain;③ Implement concrete and well-defined policy measures with urgency. © 2025 Chemical Industry Press Co., Ltd.. All rights reserved.

关键词： 晚期非小细胞肺癌   EGFR-TKI   疗效   循环肿瘤细胞   循环肿瘤DNA  

摘要： 目的分析接受一线EGFRTKI治疗的非小细胞肺癌患者的外周血CTCs和ctDNA水平,探究CTCs和ctDNA检测对晚期肺癌疗效评估的临床价值。方法纳入109例接受一线EGFR-TKI治疗的非小细胞肺癌患者,在基线和治疗1月后检测血清肿瘤指标CEA、CTCs和ctDNA水平,并行胸部CT检查,依据RECIST1.1标准评估疗效,CTCs通过富集-染色-计算算法分析恶性特征进行计数,ctDNA通过数字PCR进行。结果基线时CEA、ctDNA检测异常和治疗后外周血CTCs降低的患者生存率更低。在SD亚组患者中,脑转移、晚期的患者PFS获益更低。结论SD亚组患者的复发风险显著高于PR或CR组患者,因此,建议将CTCs和ctDNA检测应用于SD亚组患者中,以识别对EGFRTKI治疗疗效不佳的高危患者,及时介入额外治疗干预以期获得更长的无进展生存期。