关键词:
Porous polyether ether ketone(PEEK)implant
Osteointegration
Interface biomechanics
Maxillofacial implants
Finite element analyses
Fused filament fabrication(FFF)3D printing
摘要:
The bioinert nature of polyether ether ketone(PEEK)material limits the widespread clinical application of PEEK *** the porous structure is considered to improve osseointegration of PEEK implants,it is hardly used due to its mechanical *** study investigated the combined influence of the porous structure and in vivo mechanical stimulation on implantation safety and bone growth based on finite element analysis of the biomechanical behavior of the implantation *** combined control of pore size and screw preloads allows the porous PEEK implant to achieve good osseointegration while maintaining a relatively high safety level.A pore size of 600μm and a preload of 0.05 N·m are the optimal combination for the long-term stability of the implant,with which the safety factor of the implant is>2,and the predicted percentage of effective bone growth area of the bone-implant interface reaches 97%.For further clinical application,PEEK implants were fabricated with fused filament fabrication(FFF)three-dimensional(3D)printing,and clinical outcomes demonstrated better bone repair efficacy and long-term stability of porous PEEK implants compared to solid PEEK ***,good osteointegration performance of 3D-printed porous PEEK implants was observed,with an average bone volume fraction>40%three months after *** conclusion,3D-printed porous PEEK implants have great potential for clinical application,with validated implantation safety and good osseointegration.