关键词：
雷米芬太尼
靶控输注
脑电双频谱指数
BIS
听觉诱发电位指数
阿片类药物
单纯
麻醉深度
临床麻醉
镇静深度
摘要：
Objective The aim of this study was to investigate if target-controlled-infusion of remifentanil as sole agent affect bispectal index(BIS) and auditory evoked potential index (AEPI).Methods Twenty two ASAⅠ-Ⅱpatients scheduled for elective surgery were enrolled in this study.A effect-site target-controlled infusion of remifentanil was started to increase concentration gradually , the initial remifentanil concentration was set at 2.0 ng·mL -1 and was increased by 1.0 ng·mL -1 until 8.0 ng·mL -*** baseline and at each successive target concentration of remifentanil ,the BIS,AEPI ,observer’s assessment of alertness/sedation (OAA/S) ,hemodynamic variables and respiratory rate were *** Increasing predicted remifentanil effect-site concentration(CeREMI) decreased BIS value,compared with 0 ng·mL -1,the mean values of BIS were significantly reduced from 4.0 ng·mL -1(P<0.05).No significant difference in AEPI values were *** was great variation existing in reaction to remifentanil in *** value decreased obviously in 9 patients(≤70)but in another 10 patients remained unchanged(≥90).In 9 remifentanil-sensitive patients,the spearman correlation coefficient of BIS mean value between CeREMI was -0.715 and between OAA/S was ***,in another10 remifentanil-insensitive patients,we had not found any correlation in BIS mean value between CeREMI or OAA/S. Conclusion We conclude that at the concentration used in clinical practice,great variation exists in patients’ reaction to *** remifentanil affects BIS or not depend on if it produce sedative effect in *** have to consider the individual difference of BIS in remifentanil application.
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