关键词： DIHYDROPYRIMIDINES  

摘要： N-t-Butylacetamidines I on heating with methyl acrylate (2) at 200 degrees gave the 4,5-dihydro-3H-pyridin-2-one derivatives 5. Michael addition of the acetamidines 1 as their ene-1,1-diamine tautomers 1' to 2 and the subsequent cyclization of the adducts gave derivatives 5. Amidines 1 on reaction with trimethyl ethylenetri-carboxylate (9) or dimethyl acetylenedicarboxylate (12) afforded 3,4-dihydropyrrol-2-one 11 or 1,3-dihydropyrrol-2-one derivatives 13.

关键词： 5-MEMBERED HETEROCYCLES   AROMATICITY INDEX   REARRANGEMENTS   3-BENZOYL-5-PHENYL-1   2   4-OXADIAZOLE   DERIVATIVES   CHEMISTRY   ROUTE   2   5-BIS(TRIFLUOROMETHYL)-1   3   4-OXADIAZOLE   TRANSFORMATIONS   1   2   4-TRIAZINES  

摘要： The reaction of 3-benzoyl-5-perfluoroalkyl-1,2,4-oxadiazoles with hydrazine has been investigated, evidencing the possibility of competitive reaction paths. Nucleophilic addition of the hydrazine to the electrophilic C(5) of the 1,2,4-oxadiazole ring, followed by ring opening and ring closure with enlargement, leads with high yield and in very mild experimental conditions to the formation of Z-oximes of 3-perfluoroalkyl-6-phenyl-2H-1,2,4-triazin-5-ones (11a-c) as major products of the reaction. In turn, the hydrazine can attack the electrophilic carbonyl carbon giving 4-perfluoroacylamino-5-phenyl-2H-1,2,3-triazoles (13a-c) through the well-known Boulton-Katritzky rearrangement of the intermediate hydrazones.

关键词： 吡唑   咪唑   苯并咪唑   合成   生物活性  

摘要： 1-甲基-3-乙基-4-取代-5-吡唑甲酰氯与含氮杂环反应,合成了8个新型结构的双杂环化合物。其结构经1HNMR,IR,MS和元素分析表征。初步生物活性实验结果表明:在500μg·mL-1,部分化合物对稻黑尾叶蝉的抑制活性达到53.57%。

关键词： 吡啶   异噁唑   生物活性   单晶结构   杂环化合物  

摘要： 吡啶类、异噁唑类和1，3-噻唑类化合物具有广泛的生物活性，在农药和医药研究中有着重要作用。本论文利用国内资源丰富的有机化工产品双乙烯酮的衍生物乙酰乙酸乙酯为起始原料，设计合成了吡啶类、异噁唑类和噻唑类三大系列共97个新杂环化合物，这些化合物均经元素分析和1HNMR的验证，部分化合物经过IR和MS的进一步验证。所合成化合物的通式如下：\n 初步生物活性测定结果表明，吡啶类化合物有一定的杀菌和除草活性；部分异噁唑类化合物有好的除草活性和植物生长调节活性；噻唑类化合物有一定的杀菌活性。论文还讨论了目标化合物的构效关系。\n 测定了化合物N-(1-氰基-1，2-二甲基丙基)-5-甲基-4-异噁唑酰胺的单晶。

关键词： HETEROCYCLIC compounds   PYRIDINE   THIAZOLES   CHEMICAL processes   ORGANIC cyclic compounds   ORGANIC chemistry  

摘要： Perfluoro(2-methyl-2-pentene) and perfluoro(5-aza-4-nonene) react with 1,4,5,6-tetrahydropyrimidine-2-thiol, pyridine-2-thiol, and 1,2,4-triazole-3-thiol to afford fused heterocyclic systems, while their reactions with tetrahydrothiazole-2-thione and pyrimidine-2-thiol result in replacement of the fluorine atom at the double bond. Treatment of 3,3,3-trifluoro-1-pentafluoroethyl-2-trifluoromethyl-1-pentenyl isothiocyanate with ammonia gives N-(3,33-trifluoro-1-pentafluoroethyl-2-trifluoromethyl-1-propenyl)thiourea which undergoes ring closure to 4-tetratluoroethylidene-5,5-bis(trifluoromethyl)-4,5-dihydrothiazol-2-amine. Possible cyclization paths and the effect of the 1,3(N,S)-dinucleophile nature on the direction of nucleophilic addition at the double bond are discussed.

关键词： 聚合物   支持   组合化学   稠杂环化合物  

摘要： 综述了近几年稠杂环化合物的固相和液相合成研究进展.

关键词： 螺杂环   甲亚胺叶立德   环加成   合成  

摘要： The new fused quinazoline spiro-heterocyclic compounds were synthesized by combining the fused thiazolidone and quinazoline structure with spiro-heterocyclic structure for the purpose to get novel bio-active compounds. Dipolar azomethine ylides reacted with dipolarphile 2-arylmethylene-9-benzylidene-5-phenyl-6,7,8,9-tetrahydro-5H-thiazolo[2,3-b]quinazoline-3-one via 1,3-dipolar cycloaddition to give nine fused quinazoline spiro-heterocyclic compounds. The configuration and conformation of the products were determined by elementary analysis, 1H NMR, IR and X-ray crystal analysis. The results also revealed that the reaction was stereospecific.

关键词： 3-氯甲基吡啶盐酸盐   含氮杂环化合物   N-烷基化  

摘要： 以3 氯甲基吡啶盐酸盐和含氮杂环化合物四氢吡咯、哌啶、吗啉、哌嗪及咔唑为原料,通过N 烷基化反应,合成了6个N (3 吡啶基甲基)氮杂环化合物。3 氯甲基吡啶盐酸盐分别与四氢吡咯、哌啶、吗啉在二甲亚砜中于50℃下反应3h,后在室温下反应16h,得到N (3 吡啶基甲基)四氢吡咯、N (3 吡啶基甲基)哌啶及N (3 吡啶基甲基)吗啉,收率分别为87 1%、85 5%和73 1%;3 氯甲基吡啶盐酸盐与无水哌嗪以不同的投料比〔n(3 氯甲基吡啶盐酸盐)∶n(无水哌嗪)=1∶2 67和3∶1),分别在甲醇中于50℃下反应8h和10h,得到N (3 吡啶基甲基)哌嗪和N,N′ 二(3 吡啶基甲基)哌嗪,收率分别为82 4%和61 3%;3 氯甲基吡啶盐酸盐与咔唑在N,N 二甲基甲酰胺中于室温下反应12h,得到9 (3 吡啶基甲基)咔唑,收率93 7%。用1HNMR和13CNMR对产品进行了表征,证明了合成方法的可靠性。

摘要： The small heterocyclic compounds pifithrin-α, also called PFT-α (1), and its closed-ring counterpart IBT ( 2) have been described in the literature as p53 and STAT6 inhibitors, respectively. We investigated both events and prepared novel compounds, structurally related to 1 and 2, with enhanced bioactivity. IL-4 and IL-13 signaling through the STAT6 pathway are crucial cytokines for the regulation of protective immune responses. Moreover, recent data indicates that they inhibit apoptosis in malignant B cells and other cancer cells. Using various survival/proliferation assays we report that certain of our compounds induce death in chronic lymphocytic leukemia (CLL) and Hodgkin's lymphoma (HL) cells by inhibiting the IL-4/IL-13 pathway linked to the enhanced survival of the malignant cells. Moreover, we confirm the relationship to this pathway by showing a decrease in expression of the STAT6-dependent 12/15-lipoxygenase (-LOX) gene by our compounds. The chemoprotection of cells from apoptosis induced by toxins or ionizing radiation could be important for biodefense, and in the treatment of acute injuries. We report that some of our small heterocyclic analogs, including fused benzothiazoles, benzimidazoles and related compounds, abrogated thymocyte apoptosis induced by dexamethasone and γ-irradiation. Optimization of the structure, based on the findings from our screen, lead to the preparation of several compounds that showed increased bioactivity. In general, the PFT-α and aromatic IBT analogs were less inherently toxic to mouse thymocytes and had greater cytoprotective ability than other isosteric ring systems. However, the most potent compound was a quinolinium salt (95), which was at least 300 fold more potent than the reference compound PFT-α, with an IC50 value of 0.013 μM compared to 4.16 μM for 1 in the DEX-induced apoptosis assay. Those compounds also provided significant protection against γ-radiation-induced apoptosis of thymocytes and protected mice from γ-

关键词： 水相   芳醛   十六烷基三甲基溴化铵   丙二酸亚异丙酯   5,5-二甲基-1   3-环己二酮   1-苯基-3-甲基-5-吡唑啉酮   缩合  

摘要： 本文共分2 章: 第1 章:近年水相中各种有机反应的研究进展近年来,以水作为有机反应的溶剂的报道相继出现,水相中的有机合成越来越成为有机化学研究的热点。本文综述了水介质中进行的各类有机化学反应。 第2 章:水中一些有机杂环化合物的合成 2.1 水中“一锅法”合成2-氨基-3-氰基-4-芳基-7,7-二甲基-5-氧代-4H-5,6,7,8-四氢苯并[b]吡喃分别以HTMAB 和十二烷基苯磺酸(DBSA)为催化剂,芳醛、丙二腈和5,5-二甲基-1,3-环己二酮为原料于水中一步生成2-氨基-3-氰基-4-芳基-7,7-二甲基-5-氧代-4H-5,6,7,8-四氢苯并[b]吡喃. 操作简便、产率较高,而且对环境友好。 2.2 水中4-芳基-7,7-二甲基-5 氧代-3,4,5,6,7,8-六氢香豆素的合成芳醛、丙二酸亚异丙酯和5,5-二甲基-1,3-环己二酮在HTMAB 的催化下,于水中常温搅拌即可一步生成4-芳基-7,7 二甲基-5 氧代-3,4,5,6,7,8-六氢香豆素,反应条件温和,后处理简便,大部分都为新化合物。 2.3 水中3-甲基-6-氨基-5-氰基-4-芳基-1-苯基-1,4-二氢吡喃[2,3-c]吡唑的洁净合成 芳醛、丙二腈和3-甲基-1-苯基-2-吡唑啉-5-酮在水中HTMAB 存在的条件下,一步即可高产率生成3-甲基-6-氨基-5-氰基-4-芳基-1-苯基-1,4-二氢吡喃[2,3-c]吡唑。