关键词:
radiomics
magnetic resonance imaging
multiple myeloma
cytogenetics
classifier
摘要:
Background Radiomics has shown promising results in the diagnosis, efficacy, and prognostic assessments of multiple myeloma (MM). However, little evidence exists on the utility of radiomics in predicting a high-risk cytogenetic (HRC) status in MM. Purpose To develop and test a magnetic resonance imaging (MRI)-based radiomics model for predicting an HRC status in MM patients. Study Type Retrospective. Population Eighty-nine MM patients (HRC [n: 37] and non-HRC [n: 52]). Field Strength/Sequence A 3.0 T;fast spin-echo (FSE): T1-weighted image (T1WI) and fat-suppression T2WI (FS-T2WI). Assessment Overall, 1409 radiomics features were extracted from each volume of interest drawn by radiologists. Three sequential feature selection steps-variance threshold, SelectKBest, and least absolute shrinkage selection operator-were repeated 10 times with 5-fold cross-validation. Radiomics models were constructed with the top three frequency features of T1WI/T2WI/two-sequence MRI (T1WI and FS-T2WI). Radiomics models, clinical data (age and visually assessed MRI pattern), or radiomics combined with clinical data were used with six classifiers to distinguish between HRC and non-HRC statuses. Six classifiers used were support vector machine, random forest, logistic regression (LR), decision tree, k-nearest neighbor, and XGBoost. Model performance was evaluated with area under the curve (AUC) values. Statistical Tests Mann-Whitney U-test, Chi-squared test, Z test, and DeLong method. Results The LR classifier performed better than the other classifiers based on different data (AUC: 0.65-0.82;P < 0.05). The two-sequence MRI models performed better than the other data models using different classifiers (AUC: 0.68-0.82;P < 0.05). Thus, the LR two-sequence model yielded the best performance (AUC: 0.82 +/- 0.02;sensitivity: 84.1%;specificity: 68.1%;accuracy: 74.7%;P < 0.05). Conclusion The LR-based machine learning method appears superior to other classifier methods for assessing HRC in MM. Ra