ISBN: (纸本)9787030686497

关键词： Chronic pain   Dorsal horn   mGluR5   Arf6   Small GTPase   Membrane trafficking  

摘要： Group I metabotropic glutamate receptors (mGluRs), mGluR1 and mGluR5, in the spinal cord are implicated in nociceptive transmission and plasticity through G protein-mediated second messenger cascades leading to the activation of various protein kinases such as extracellular signal-regulated kinase (ERK). In this study, we demonstrated that cytohesin-2, a guanine nucleotide exchange factor for ADP ribosylation factors (Arfs), is abundantly expressed in subsets of excitatory interneurons and projection neurons in the superficial dorsal horn. Cytohesin-2 is enriched in the perisynapse on the postsynaptic membrane of dorsal horn neurons and forms a protein complex with mGluR5 in the spinal cord. Central nervous system-specific cytohesin-2 conditional knockout mice exhibited reduced mechanical allodynia in inflammatory and neuropathic pain models. Pharmacological blockade of cytohesin catalytic activity with SecinH3 similarly reduced mechanical allodynia and inhibited the spinal activation of Arf6, but not Arf1, in both pain models. Furthermore, cytohesin-2 conditional knockout mice exhibited reduced mechanical allodynia and ERK1/2 activation following the pharmacological activation of spinal mGluR1/5 with 3,5-dihydroxylphenylglycine (DHPG). The present study suggests that cytothesin-2 is functionally associated with mGluR5 during the development of mechanical allodynia through the activation of Arf6 in spinal dorsal horn neurons.

关键词： Ovarian cancer   Poly-ADP ribose Polymerase inhibitors   PARP inhibitor   Haematologic malignancy   Myelodysplastic syndrome   Acute myeloid leukaemia   Outcome  

ISBN: (纸本)9787565730757

关键词： 数据处理  

ISBN: (纸本)9787516661284

摘要： 本书主要有以下三大特点：（1）理论与实战相结合，不仅对Hadoop组件基本原理、编程模型等基础理论进行深入的介绍，而且从环境搭建、案例分析、项目创建和代码实现等方面系统性地介绍如何基于hadoop组件接口开发大数据技术应用系统；（2）由浅入深，在实战方面，首先，基于接口实例，介绍接口功能及基本编程框架；然后，进一步基于综合项目案例，介绍项目实战开发的具体过程。使得读者深入浅出，避免读者陷入理解基本原理和接口，却难以具体设计和编程实现实际应用中大数据处理算法的困境；（3）系统开发前后端相结合，在项目实战案例中，本书不是仅仅介绍如何基于大数据平台实现大数据处理的过程，而是将Web系统的前后端相结合作为一个整体，进行项目总体设计和功能实现，更加贴切于现实的项目应用需求，从而提高了读者的项目实战能力和开发水平。

关键词： Aeromagnetic surveys   Magnetic anomaly   Structural mapping   Interpreted lineament   Hidden faults   North-Eastern Morocco  

摘要： This work focuses on assembling three aeromagnetic geophysical surveys with different flight attitudes and sampling profiles directions. The airborne data analysis and processing highlight magnetic source boundaries and new structural features mostly hidden by Quaternary sedimentary covers at the Oujda-Debdou-Guercif (ODG) zone of North-Eastern Morocco. We have established magnetic anomaly and lineaments maps performing sophisticated filtering techniques. The reduction to the pole of the residual magnetic map shows three different zones: (1) Strong magnetization zones express the Tertiary and Quaternary volcanic lavas, which outcropped partly in the Oujda and Saka regions. They also reflect the Paleozoic basement and the iron-manganese mineralization concentrated in the Triassic beds. (2) Zones of relatively low magnetic response came from basaltic cones, filled in a small graben at the Oujda region. (3) Zones of low magnetization correspond to the Quaternary and Tertiary cover in addition to the Triassic-Jurassic deposits. The released magnetic lineament maps emphasize new deep faults of this region and trace subsurface faults mapped by traditional structural studies using horizontal derivation, vertical derivation, and Euler's deconvolution techniques. We have considered some lineaments that arrived at 2 km of depth major deep-seated structures. We have identified NE-SW and E-W trending faults that inherited from Hercynian and Alpine directions, respectively. The geodynamic interpretation of these lineaments reveals their participation in the structuring of several subsidence basins. Our synthetic structural map of magnetic contacts gives additional structural information of the ODG zone and serves as a guide paper for all future mining exploration.

关键词： 数据处理   应用   交通运输管理   研究   物流管理  

ISBN: (纸本)9787568075206

摘要： 针对交通运输物流领域的大数据环境特点，对大数据存储以及大数据分析方法进行分析研究，主要内容如下：大数据环境下交通运输物流领域数据资源存储、计算和资源调度管理、离线数据并行计算和在线数据实时计算等方法进行剖析，实现了实时热力分析、车货信息资源实时匹配、热点词分析、物流企业信用评价等典型的交通运输物流领域大数据应用。主要章节包括：绪论；大数据分析平台软件技术基础架构；交通运输物流大数据的数据组织与描述；交通运输物流领域流式数据实时分析与应；交通运输物流领域离线数据并行计算与应用。

关键词： Aphid   beetle   insect classification   random forest classification   wingbeat harmonics  

摘要： Bioacoustic methods play an increasingly important role for the detection of insects in a range of surveillance and monitoring programmes. Weak-flying insects evade detection because they do not yield sufficient audio information to capture wingbeat and harmonic frequencies. These inaudible insects often pose a significant threat to food security as pests of key agricultural crops worldwide. Automatic detection of such insects is crucial to the future of crop protection by providing critical information to assess the risk to a crop and the need for preventative measures. We describe an experimental set-up designed to derive audio recordings from a range of weak-flying aphids and beetles using an LED array. A rigorous data processing pipeline was developed to extract meaningful features, linked to morphological characteristics, from the audio and harmonic series for six aphid and two beetle species. An ensemble of over 50 bioacoustic parameters was used to achieve species discrimination with a success rate of 80%. The inclusion of the dominant and fundamental frequencies improved prediction between beetles and aphids because of large differences in wingbeat frequencies. At the species level, error rates were minimized when harmonic features were supplemented by features indicative of differences in species' flight energies.

ISBN: (纸本)9787121422492