关键词： 工程机械行业   机械产业   提速   助推   机械工业   设备制造商   BICES   日本建筑  

摘要： 由中国工程机械工业协会联手美国设备制造商协会、日本建筑机械工业协会、韩国建筑机械工业协会联合主办的全球工程机械产业大会将在第十一届北京BICES展会期间举办，该次大会主题定为”机会、融合、应变“，将重点讨论”未来中国与全球工程机械产业的发展机遇“、”中国与全球工程机械行业如何深度融合，协同发展，

关键词： CO2-H2O solutions   QMCF-MD   hydrogen bond   vibrational spectrum   greenhouse effects  

摘要： Structure and dynamics of a carbon dioxide molecule in water were studied by an ab initio quantum mechanical charge field molecular dynamics (QMCF-MD) simulation. Radial distribution functions, angular distribution functions, and coordination number distributions as well as dynamical data such as mean ligand residence time and vibrational spectra were utilized for the evaluation of physico-chemical properties of hydrated CO2. These data served for an assessment of hydrogen bonding between solute and solvent molecules. All the results evaluated were compared with available experimental results leading to a good agreement between theoretical and experimental data. The average lifetime of hydrogen bonding between H2O and CO2 resulted as 0.61 ps, which is higher than the hydrogen bonding lifetime of pure water. The vibrational frequencies were also calculated for all the modes of hydrated CO2 to demonstrate the influence of solvent molecules on the IR spectrum of the solute. (C) 2010 Wiley Periodicals, Inc. Int J Quantum Chem 111: 1370-1378, 2011

关键词： Multiple Virtual Storage   Precursor Cell Lymphoblastic Leukemia-Lymphoma   Chronic lymphocytic leukemia   Cell Death   Kinetics   Adult Acute Lymphoblastic Leukemia   tumor necrosis  

摘要： Clinical trials using vaccine measles virus (MV) as anticancer therapy are already underway. We compared the oncolytic potential of MV in two B-cell malignancies;adult acute lymphoblastic leukemia (ALL, an aggressive leukemia) and chronic lymphocytic leukemia (CLL, an indolent leukemia overexpressing Bcl-2) using patient-derived material. In vitro, distinct cytopathological effects were observed between MV-infected primary ALL and CLL cells, with large multinucleated syncytia forming in ALL cultures compared to minimal cell-to-cell fusion in infected CLL cells. Cell viability and immunoblotting studies confirmed rapid cell death in MV-infected ALL cultures and slower MV oncolysis of CLL cells. In cell lines, overexpression of Bcl-2 diminished MV-induced cell death providing a possible mechanism for the slower kinetic of MV oncolysis in CLL. In vivo, intratumoral MV treatment of established subcutaneous ALL xenografts had striking antitumor activity leading to complete resolution of all tumors. The antitumor activity of MV was also evident in disseminated ALL xenograft models. In summary, both ALL and CLL are targets for MV-mediated lysis albeit with different kinetics. The marked sensitivity of both primary ALL cells and ALL xenografts to MV oncolysis highlights the tremendous potential of MV as a novel replicating-virus therapy for adult ALL.

关键词： EXPERIMENTS   STRAINS & stresses (Mechanics)   COUPLINGS (Gearing)   TEMPERATURE measurements   CRYSTAL grain boundaries   MOTION  

摘要： Recent results of experimental research into stress-induced grain boundary migration in aluminum bicrystals are reported. Boundary migration under a shear stress was observed to be coupled to a lateral translation of the grains for planar symmetrical aOE (c) 100 > tilt boundaries. This coupling proved to be the typical migration mode of any aOE (c) 100 > tilt boundary, no matter whether low- or high-angle, low I pound CSL coincidence or non-coincidence boundary. The measured ratios of normal boundary motion to the tangential displacement of grains are in an excellent agreement with theoretical predictions. The migration-shear coupling is also observed for asymmetrical aOE (c) 100 > boundaries. Measurements of the temperature dependence of coupled boundary migration revealed that there is a specific misorientation dependence of migration activation parameters. Grain boundaries can act during their motion under the applied stress as sources of lattice dislocations that leads to the generation and growth of new grains in the boundary region. The rate of stress-induced boundary migration decreases with increasing solute content in aluminum. Both the migration activation enthalpy and the pre-exponential mobility factor were found to increase with rising impurity concentration.

关键词： Kinetics  

摘要： This article focuses on the mechanically induced reactivity of boehmite prepared by thermal decomposition of gibbsite. Boehmite, which retained the morphology of gibbsite, was characterized by a specific surface area of 264 m(2)/g. Mechanical activation (MA) was carried out in a planetary mill up to 240 minutes. The samples were characterized in terms of morphology, characteristic particle diameters, Brunauer Emmett Teller (BET) specific surface area (SSA(BET)), microcrystallite dimension (MCD), microstrain (epsilon) and Fourier transform infrared spectroscopy. The reactivity was construed from the kinetics of thermal transformation of boehmite into gamma-Al2O3. The transformation observed between 600 K and 900 K (327 A degrees C and 627 A degrees C), manifested itself as two overlapping peaks in the differential thermogravimetric plot. These peaks correspond to two stages of dehydroxylation involving Al2OH and AlOH groups in succession. The peaks were resolved using Gaussian deconvolution. The reactivity was assessed separately for the two stages by comparing the fraction reacted in MA samples (alpha) with that of nonactivated sample (alpha (ref)). During both stages, enhanced kinetics, as revealed by alpha-alpha (ref) plots, indicated an increase in reactivity with MA. The transformation mechanism conformed to n (th) order reaction (f[alpha] = [1 - alpha] (n) with n = 1.3-1.5 in both stages). Values of n remained similar for the activated and reference samples. Activation energies (E (a)) for the first and second dehydroxylation stages were respectively 115 and 300 kJ/mol for the nonactivated sample. E (a) for the second stage decreased exponentially to a value of 222 kJ/mol after 240 minutes of milling. An anomalous negative correlation between reactivity and SSA(BET) was observed. Reactivity parameters were strongly correlated with MCD and epsilon. A plausible explanation for the observed correlations is presented.

关键词： 2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide   Dealkylation   additional mass   Cholinesterases   mass measurement   adduct   salicyl alcohol  

摘要： Aerotoxic syndrome is assumed to be caused by exposure to tricresyl phosphate (TCP), an antiwear additive in jet engine lubricants and hydraulic fluid. CBDP (2-(ortho-cresyl)4H-1,2,3-benzodioxaphosphoran-2-one) is the toxic metabolite of triortho-cresylphosphate, a component of TCP. Human butyrylcholinesterase (BChE;EC 3.***.1.8) and human acetylcholinesterase (AChE;EC 3.***.1.7) are irreversibly inhibited by CBDP. The bimolecular rate constants of inhibition (k(i)), determined under pseudo-first-order conditions, displayed a biphasic time course of inhibition with k(i) of 1.6 x 10(8) M-1 min(-1) and 2.7 x 10(7) M-1 min(-1) for E and E' forms of BChE. The inhibition constants for AChE were 1 to 2 orders of magnitude slower than those for BChE. CBDP-phosphorylated cholinesterases are nonreactivatable due to ultra fast aging. Mass spectrometry analysis showed an initial BChE adduct with an added mass of 170 Da from cresylphosphate, followed by dealkylation to a structure with an added mass of 80 Da. Mass spectrometry in O-18-water showed that O-18 was incorporated only during the final aging step to form phospho-serine as the final aged BChE adduct. The crystal structure of CBDP-inhibited BChE confirmed that the phosphate adduct is the ultimate aging product. CBDP is the first organophosphorus agent that leads to a fully dealkylated phospho-serine BChE adduct.

关键词： EPOXY compounds   COPPER   DYNAMICS of a particle   MOLECULAR models   STRAINS & stresses (Mechanics)   MECHANICS (Physics)  

摘要： The current paper successively applies molecular modeling and mesoscale modeling to scale mechanical models from an atomistic angstrom level to a sub-micron level and determine modulus, stress/strain behavior and defect formation in an epoxy and epoxy-copper interface. The results will show that molecular modeling may be applied directly to parameterize the bead properties used in the mesoscale model, which scale to the physical properties so could provide a means to understand interface behavior linked directly back to molecular origins. (C) 2011 Elsevier Ltd. All rights reserved.

关键词： Complexity   Entropy   Heart rate variability   Weaning outcome  

摘要： Purpose: The aim of the study was to investigate heart rate (HR) and respiratory rate (RR) complexity in patients with weaning failure or success, using both linear and nonlinear techniques. Materials and Methods: Forty-two surgical patients were enrolled in the study. There were 24 who passed and 18 who failed a weaning trial. Signals were analyzed for 10 minutes during 2 phases: (1) pressure support (PS) ventilation (15-20 cm H2O) and (2) weaning trials with PS (5 cm H2O). Low-and high-frequency (LF, HF) components of HR signals, HR multiscale entropy (MSE), RR sample entropy, cross-sample entropy between cardiorespiratory signals, Poincare plots, and alpha 1 exponent were computed in all patients and during the 2 phases of PS. Results: Weaning failure patients exhibited significantly decreased RR sample entropy, LF, HF, and alpha 1 exponent, compared with weaning success subjects (P < .001). Their changes were opposite between the 2 phases, except for MSE that increased between and within groups (P < .001). A new model including rapid shallow breathing index (RSBI), alpha 1 exponent, RR, and cross-sample entropies predicted better weaning outcome compared with RSBI, airway occlusion pressure at 0.1 second (P-0.1), and RSBI x P-0.1 (conventional model, R-2 = 0.887 vs 0.463;P < .001). Areas under the curve were 0.92 vs 0.86, respectively (P < .005). Conclusions: We suggest that nonlinear analysis of cardiorespiratory dynamics has increased prognostic impact upon weaning outcome in surgical patients. (C) 2011 Elsevier Inc. All rights reserved.

关键词： FLUID mechanics   SHEAR (Mechanics)   RELAXATION phenomena   ELASTICITY   NONLINEAR theories   LANGEVIN equations   RHEOLOGY   COUPLING constants (Nuclear physics)  

摘要： We apply the quiescent and mechanically driven versions of nonlinear Langevin equation theory to study how particle softness influences the shear modulus, the connection between shear elasticity and activated relaxation, and nonlinear rheology of the repulsive Hertzian contact model of dense soft sphere fluids. Below the soft jamming threshold, the shear modulus follows a power law dependence on volume fraction over a narrow interval with an apparent exponent that grows with particle stiffness. To a first approximation, the elastic modulus and transient localization length are controlled by a single coupling constant determined by local fluid structure. In contrast to the behavior of hard spheres, an approximately linear relation between the shear modulus and activation barrier is predicted. This connection has recently been observed for microgel suspensions and provides a microscopic realization of the elastic shoving model. Yielding, shear and stress thinning of the alpha relaxation time and viscosity, and flow curves are also studied. Yield strains are relatively weakly dependent on volume fraction and particle stiffness. Shear thinning commences at values of the effective Peclet number far less than unity, a signature of stress-assisted activated relaxation when barriers are high. Apparent power law reduction of the viscosity with shear rate is predicted with a thinning exponent less than unity. In the vicinity of the soft jamming threshold, a power law flow curve occurs over an intermediate reduced shear rate range with an apparent exponent that decreases as fluid volume fraction and/or repulsion strength increase. [ABSTRACT FROM AUTHOR]

标准号: BS EN ISO 22868-2011

摘要： CAUTION — Some of the test procedures specified in this International Standard involve processesthat could lead to a hazardous situation. Any person performing tests in accordance with thisInternational Standard shall be appropriately trained in the type of work to be carried *** International Standard specifies a noise test code for determining, efficiently and under standardizedconditions, the noise emission characteristics of portable, hand-held, combustion-engine-powered forest andgarden machines, including chain-saws, brush-cutters, grass-trimmers, pole-mounted powered pruners,hedge-trimmers and garden blowers/vacuums. Noise emission characteristics include the A-weightedemission sound pressure level at the operator position and the A-weighted sound power level.