关键词： 临床路径   神经病学   教学效果   实习带教   教学质量  

摘要： 目的分析临床路径教学应用于神经病学的教学效果。方法选取2017级学生40名为研究组,将临床路径教学应用于神经病学的教学中;选取2016级学生40名为对照组,采用传统教学法授课。完成教学任务后,通过考核成绩和发放调查问卷方法来评估反馈教学实施情况。结果研究组病历书写成绩(87.70±3.72)分、病例分析成绩(85.90±3.12)分、临床操作成绩(83.40±2.57)分、理论知识成绩(86.40±3.13)分与对照组相比,差异有统计学意义(P<0.05);研究组学生对带教方法的满意度、在激发学生学习兴趣满意度、培养学生临床思维满意度、针对患者的规范化满意度及个体化诊疗满意度、对带教教师授课满意度都达到90%及以上。结论将临床路径教学应用神经科疾病的教学,将会明显改善临床具体病例与教学环节不一致的矛盾,大大提高带教效果。

关键词： 中文核心期刊   来源期刊   神经免疫学   科研成果   科研人员   中国学术期刊   中国免疫学会   神经病学  

摘要： 《中国神经免疫学和神经病学杂志》是全国唯一与神经免疫学相关的神经病学学术性期刊,由国家卫健委主管,北京医院、中国免疫学会神经免疫分会主办,国内外公开发行。本刊以从事神经免疫学和神经病学临床和科研人员等为主要读者对象,报道神经疾病领域尤其是神经免疫学领域的科研成果。本刊属中国科技论文统计源期刊、中国科技核心期刊、中文核心期刊、中国科技引文数据库来源期刊与中国学术期刊综合评价数据库来源期刊等。

关键词： 微信小程序   翻转课堂   神经病学  

摘要： 神经病学课程内容多、教学难度大,传统教学方法已不能满足当前教学需要。本文回顾基于微信小程序的翻转课堂教学模式的产生和发展,介绍该模式在医学教育中的应用现状,对其在神经病学教学中的应用进行展望,指出面临的困境。

关键词： 新型冠状病毒肺炎疫情   神经病学   临床教学   角色  

摘要： 新型冠状病毒肺炎疫情对《神经病学》临床教学工作带来了冲击,改变了传统的教学模式。新形势下《神经病学》临床教学工作和临床带教老师角色都有了新变化。本文结合《神经病学》临床教学经验,对疫情防控形势下《神经病学》临床教师的角色定位做了阐述,提出新形势下《神经病学》临床教师应该在教学过程中扮演好临床教学的管理者、临床知识的传播者、临床行为的示范者和临床学生的保护者角色。《神经病学》临床教师在明确了新的角色定位后,能够不断提高教学水平和学生培养质量,为临床输送更多的高水平人才。

摘要： ~~

关键词： 临床神经病学   微信公众平台   信息反馈   微信号   三种方式   杂志  

摘要： 为了加强与广大读者、作者以及专家的沟通,及时进行信息反馈,《临床神经病学杂志》微信公众平台于2015年8月正式开通,欢迎大家关注!您可通过以下三种方式关注《临床神经病学杂志》微信公众平台:1、搜索公众订阅号名称"临床神经病学杂志"添加关注;2、搜索微信号"lcsjbx"添加关注;3、扫描位于本刊目次页右上角的微信二维码。

摘要： 《临床神经病学杂志》于1988年7月创刊,系国家级神经病学专业性学术期刊,并已入选中国科技核心期刊,由南京医科大学主管,南京医科大学附属脑科医院主办。国内统一刊号CN 32-1337/R,国际标准刊号ISSN 1004-1648。本刊曾荣获第二届全国优秀科技期刊奖及连续多次江苏省优秀期刊奖,曾被北京大学中文核心期刊收录,并先后被美国化学文摘(CA)、俄罗斯文摘杂志(РЖ)、波兰哥白尼索引(IC)、美国《乌利希国际期刊指南》以及荷兰医学文摘(EMBASE)等几大数据库收录。

关键词： Xinglou Chengqi Decoction   Ischemic stroke   Gut microbiota   Network pharmacology  

摘要： The current study was designed to explore the brain protection mechanism of Xinglou Chengqi Decoction(XCD)based on gut microbiota analysis and network pharmacology. A transient middle cerebral artery occlusion(MCAO) model of mice was established, followed by behavioral evaluation, TTC and TUNEL staining. Additionally, to investigate the effects of gut microbiota on neurological function after stroke, C57BL/6 mice were treated with anti-biotic cocktails 14 days prior to ischemic stroke(IS) to deplete the gut microbiota. High-throughput 16S rDNA gene sequencing, metabonomics technique, and flow multifactor technology were used to analyze bacterial communities, SCFAs and inflammatory cytokines respectively. Finally, as a supplement, network pharmacology and molecular docking were applied to fully explore the multicomponent-multitarget-multichannel mechanism of XCD in treating IS, implicated in ADME screening, target identification, network analysis, functional annotation, and pathway enrichment *** found that XCD effectively improved neurological function, relieved cerebral infarction and decreased the neuronal ***, XCD promoted the release of anti-inflammatory factor like IL-10, while down-regulating pro-inflammatory factors such as TNF-α, IL-17A, and IL-22. Furthermore, XCD significantly increased the levels of short chain fatty acids(SCFAs), especially butyric acid. The mechanism might be related to the regulation of SCFAs-producing bacteria like Verrucomicrobia and Akkermansia, and bacteria that regulate inflammation like Paraprevotella, Roseburia, Streptophyta and Enterococcu. Finally, in the network pharmacological analysis, 51 active compounds in XCD and 44 intersection targets of IS and XCD were selected. As a validation, components in XCD docked well with key targets. It was obviously that biological processes were mainly involved in the regulation of apoptotic process, inflammatory response, response to fatty acid, and regulation of est

关键词： Neurofilament   COVID-19   NfL   Hyposmia   Hypogeusia   SARS-CoV-2  

摘要： The persistence of neurological symptoms after SARS-CoV-2 infection, as well as the presence of late axonal damage, is still unknown. We performed extensive systemic and neurological follow-up evaluations in 107 out of 193 consecutive patients admitted to the COVID-19 medical unit, University Hospital of Verona, Italy between March and June 2020. We analysed serum neurofilament light chain (NfL) levels in all cases including a subgroup (n = 29) of patients with available onset samples. Comparisons between clinical and biomarker data were then performed. Neurological symptoms were still present in a significant number (n = 49) of patients over the follow-up. The most common reported symptoms were hyposmia (n = 11), fatigue (n = 28), myalgia (n = 14), and impaired memory (n = 11) and were more common in cases with severe acute COVID-19. Follow-up serum NfL values (15.2 pg/mL, range 2.4-62.4) were within normal range in all except 5 patients and did not differentiate patients with vs without persistent neurological symptoms. In patients with available onset and follow-up samples, a significant (p < 0.001) decrease of NfL levels was observed and was more evident in patients with a severe acute disease. Despite the common persistence of neurological symptoms, COVID-19 survivors do not show active axonal damage, which seems a peculiar feature of acute SARS-CoV-2 infection.

关键词： FEES   pediatric dysphagia   sensory deficit   sensibility   sensitivity   dysphagia   ILS  

摘要： Background Aspirations are frequent in children with neurological impairment. They significantly increase the risk for acute and chronic respiratory insufficiencies leading to high morbidity and mortality. Laryngeal sensation deficits have been linked to aspirations in adults and are a suspected cause for dysphagia in children. In a similar neurological circuit as swallowing, laryngeal receptors trigger coughing as a protective airway reflex. The aim of this study was to examine the association between impaired laryngeal sensation (ILS), aspiration, and coughing in neurologically impaired children. Design and Methods In a retrospective study, 110 children with suspected dysphagia underwent a clinical evaluation of swallowing and a flexible endoscopic evaluation of swallowing (FEES) between 2013 and 2019 in the children's university clinic Dusseldorf were analyzed. Laryngeal sensation was tested by the endoscopic touch method. Associations were computed using chi(2)-test. Results Fifty-four patients (49.1%) had a neurological impairment, 56 patients (50.9%) had no or other comorbidities and served as a control cohort. Children with neurological impairment suffered from ILS significantly more often than children with no or other comorbidities (chi(2)(1) = 4.63, p = .031). ILS was associated with all other FEES variables but did not correlate with coughing. The symptom coughing correlated with aspiration in the group of neurologically impaired children and in children ILS. Conclusion ILS is a potential cause of aspirations in children with neurological impairment. Physicians need to pay special attention to the occurrence of coughing in children with neurological impairment and/or ILS since it signals aspirations that took place.