关键词： 神经病学   高峰论坛  

摘要： 由国家核心期刊《中国神经精神疾病杂志》编辑部主办的国家级继续教育项目"第二十一届国际神经病学中山高峰论坛·2018"将于2018年11月24日在广州花都皇冠假日酒店举行。本次大会将邀请国内外著名专家进行主题演讲,主要内容有脑血管病、神经遗传病、脑血管介入治疗、神经系统退行变性疾病、

关键词： Neurological diseases   Bone marrow stem cells   Intrathecal  

摘要： Background: Cellular transplantation is a promising treatment strategy for neurological diseases. Objective: To report the results of intrathecal hematopoietic stem cell therapy in different neurological diseases in the past 6 years in a single center. Methods: From October 2011 to September 2018, 220 patients with various neurological diseases were transplanted intrathecally by their bone marrow stem cells. To have a longer follow up, we only reported the first 80 patients, transplanted up to July 2015-10 patients had spinal cord injuries and paralysis, 12 had advanced Parkinson's disease, 28 had cerebral palsy, 7 had hypoxic brain damage, 2 had autism, 4 had multiple sclerosis, 5 had progressive cerebellar atrophy, and 12 had other neurological diseases. The patients were admitted to the Bone Marrow Transplant Unit. On the first day, 50-200 (median 100) mL bone marrow was aspirated from the patients' posterior iliac crests, mixed with 120 mL culture media (RPM!), and 12 mL heparin. The samples were then transferred to immunology lab in cold box. Mononuclear cells (MNCs) were separated by a Ficoll-Hypaque gradient, washed, and suspended in ringers. Cell viability was assessed with trypan blue viability test. Transplantation was performed 3-4 hours after bone marrow collection. 5-10 mL of the cerebrospinal fluids were aspirated and about 20 mL MNCs (containing stem cells) in ringers were injected intrathecally (IT). The patients were laid down on their back for 4-5 hours. The median number of MNCs was 4x10 7 (range 1-450x10(7)). The median viability of the cells was 90% (range 60%-98%). The patients received intravenous ceftriaxone every 12 hours and were discharged from the hospital few days after autologous stem cell therapy. Results: We noted clinical improvements in 9 of 12 patients with Parkinson's disease, 20 of 28 patients with cerebral palsy, 6 of 7 patients with hypoxic brain damage, 2 of 4 patients with multiple sclerosis, and 4 of 5 patients with cerebell

关键词： 磁刺激   神经病学  

摘要： 中国著名神经病学专家中国医师协会神经内科医师分会副会长中国卒中学会血管性认知障碍分会主任委员中国老年保健协会阿尔茨海默病分会(ADC)副主任委员中华医学会神经病学分会神经心理学和行为神经病学组组长安徽医科大学第一附属医院神经内科主任

关键词： 临床神经病学杂志   科技期刊学术不端文献检测系统   学术不端文献  

摘要： 为了提高编辑部对于学术不端文献的辨别能力,端正学风,维护作者权益,《临床神经病学杂志》日前已正式启用"科技期刊学术不端文献检测系统",对来稿进行逐篇检查。该系统以《中国学术文献网络出版总库》为全文比对数据库,可检测抄袭与剽窃、伪造、篡改、不当署名、一稿多投等学术不端文献,论文的文字复制比不应高于20%。如查出作者所投稿件存在上述学术不端行为,本刊将立即做退稿处理。希望广大作者在论文撰写中保持严谨、谨慎、端正的态度,自觉抵制任何有损学术声誉的行为。

关键词： Aging   Alzheimer's disease   memory consolidation   entorhinal cortex   hippocampus  

摘要： Objective: Traditional episodic memory tests employ a delayed recall length ranging from 10 to 30 min. The neurobiological process of memory consolidation extends well beyond these time intervals, however, raising the possibility that these tests might not be fully sensitive to the subtle neurocognitive changes found in early disease or age-related decline. We aimed to determine the sensitivity of a 1-week delayed recall paradigm to medial temporal lobe (MTL) structure among neurologically normal older adults. Methods: One hundred and forty functionally intact, older adults (mean age=75.8) completed a story recall test in which participants learned to 90% criterion. Recall was tested after 30-min and 1-week. Participants also completed a standardized list learning task with a 20-min delay (n=129) and a structural brain MRI. The MTL, including the parahippocampal gyrus, hippocampus, and entorhinal, was our primary region of interest. Results: Controlling for age, education, gender and total intracranial volume, the standard 20- and 30-min recalls showed no significant relationship with MTL. In contrast, 1-week recall was uniquely associated with MTL structure (partial r=.24, p=.006), specifically entorhinal (partial r=.27;p=.001) and hippocampal (partial r=.21, p=.02) volumes. Conclusion: Memory paradigms that utilize 1-week delays are more sensitive than standard paradigms to MTL volumes in neurologically normal older adults. Longer delay periods may improve detection of memory consolidation abilities associated with age-related, and potentially pathological, neurobehavioral change.

关键词： 临床神经病学杂志   办公系统  

摘要： 《临床神经病学杂志》网络采编办公系统原网址(http://***)自2018年8月15日起停用。本刊网址正式变更为http://***。您可以输入新网址域名http://***进行登录,也可以通过本刊主管单位——南京脑科医院的官方网站(http://***)的链接进行登录。此次网址变更不影响网络采编办公系统使用,原用户名及密码

关键词： Developmental disability   epilepsy   intelligence   neuropsychological assessment   psychometrics  

摘要： The assessment of intellectual abilities is intensive, time-consuming, and might be considered burdensome for patients. We examined psychometric qualities of short forms (SFs) of the Wechsler Intelligence Scales for Children (WISC-third edition) and for adults (WAIS-fourth edition), in children (n = 986;M-age = 10.9) and adults (n = 324;M-age = 40.9) with neurological disorders. SF estimates were compared with Full Scale IQ (FSIQ), obtained by a complete administration, for the entire sample and for the subgroups FSIQ < 80 and FSIQ 80. The FSIQ was correctly identified within +/- 7 points in 86% of children and 87% of adults. There were, however, some differences regarding the optimal SF subtest combination between subgroups. Although clinical inferences should not be made, SFs may be useful in research settings to obtain a global estimate of intelligence, and in clinical settings to screen periodically for possible intellectual deterioration.

ISBN: (纸本)9787117259736

关键词： 临床神经病学杂志   审稿专家  

摘要： 在过去的2017年度(2017年1月1日～2017年12月31日),《临床神经病学杂志》的各位编委和审稿人群策群力、保质保量地完成了审稿任务,在此向他们表示诚挚的谢意!以下是2017编辑年度审稿专家名单: