关键词： 上海交通大学   瑞金医院   医学院   学术期刊   SCIE   神经变性病   期刊出版   神经病学  

摘要： Translational Neurodegeneration（拟定中文名为《转化神经变性病》，简称TN），由上海交通大学医学院附属瑞金医院主办，陈生弟教授主编。期刊出版已6年，运行良好。2017年12月，TN被纳入Science Citation Index Expanded（SCIE），是国内神经病学领域的一项重要突破。2018年6月，TN将获得第一个影响因子。

关键词： 脑血管病学   青岛市   中国   十八   山东省医学会   中华医学会   脑血管疾病   神经病学  

摘要： 为了进一步提高我国脑血管疾病诊疗水平和研究能力，积极推动我国脑血管疾病规范化防治，由中华医学会、中华医学会神经病学分会主办，中华医学会神经病学分会脑血管病学组、山东省医学会、山东省医学会神经病学委员会承办的“第十八次中国脑血管病大会”将于2018年4月19—21日在山东省青岛市召开。

关键词： 翻转课堂   中西医结合   神经病学   临床教学  

摘要： 根据中西医结合神经病学的教学特点,将翻转课堂这一教学模式引入中西医结合神经病学临床教学中,并初步探索翻转课堂在该学科临床教学中的实施方法,弥补传统教学模式的缺点,最大化利用了课前、课堂时间,激发了学生的学习兴趣,实现了"以学生为中心"的教学理念,不仅增强了学生对知识的理解掌握,更促进自主学习能力、团队合作能力以及分享交流意识的全面发展,提高了学习效果。

关键词： HIV   HIV dementia   antiretroviral therapy   neuroAIDS  

摘要： Background: The differential effects of commonly prescribed combined antiretroviral therapy (cART) regimens on AIDS-defining neurological conditions (neuroAIDS) remain unknown. Setting: Prospective cohort studies of HIV-positive individuals from Europe and the Americas included in the HIV-CAUSAL Collaboration. Methods: Individuals who initiated a first-line cART regimen in 2004 or later containing a nucleoside reverse transcriptase inhibitor backbone and either atazanavir, lopinavir, darunavir, or efavirenz were followed from cART initiation until death, lost to follow-up, pregnancy, the cohort-specific administrative end of follow-up, or the event of interest, whichever occurred earliest. We evaluated 4 neuroAIDS conditions: HIV dementia and the opportunistic infections toxoplasmosis, cryptococcal meningitis, and progressive multifocal leukoencephalopathy. For each outcome, we estimated hazard ratios for atazanavir, lopinavir, and darunavir compared with efavirenz via a pooled logistic model. Our models were adjusted for baseline demographic and clinical characteristics. Results: Twenty six thousand one hundred seventy-two individuals initiated efavirenz, 5858 initiated atazanavir, 8479 initiated lopinavir, and 4799 initiated darunavir. Compared with efavirenz, the adjusted HIV dementia hazard ratios (95% confidence intervals) were 1.72 (1.00 to 2.96) for atazanavir, 2.21 (1.38 to 3.54) for lopinavir, and 1.41 (0.61 to 3.24) for darunavir. The respective hazard ratios (95% confidence intervals) for the combined end point were 1.18 (0.74 to 1.88) for atazanavir, 1.61 (1.14 to 2.27) for lopinavir, and 1.36 (0.74 to 2.48) for darunavir. The results varied in subsets defined by calendar year, nucleoside reverse transcriptase inhibitor backbone, and age. Conclusion: Our results are consistent with an increased risk of neuroAIDS after initiating lopinavir compared with efavirenz, but temporal changes in prescribing trends and confounding by indication could explain our f

关键词： 中西医结合   神经病学   临床教学   教学改革  

摘要： 中西医结合神经病学要求掌握传统医学和现代医学知识治疗神经系统常见病,是一门实践性很强的学科。培养一名合格的中西医结合神经科医生,离不开优质科学的临床教学。临床教学的目的是培养学生基本操作技能、基本临床知识及基本临床思维能力。在中西医结合神经病学的临床教学中如何优化教学方法,构建中医学与现代医学相结合的临床实践教学体系,从而提高医学生的临床能力,与住院医师规范化培养相接轨,塑造实用型人才,是医学临床教师面临的新挑战。

关键词： 临床医学教育   教育国际化   教学体会   神经病学   留学生   临床实践   内科临床教学   临床教学实践  

摘要： 国际留学生到我国进行临床医学教育的数量逐年增长,医学生的国际化是医学高等教育国际化的必然趋势,因而需不断提高我国培养国际留学生的能力。现将我们临床教学实践过程中医学留学生神经内科临床教学方面存在的问题及相关教学体会,报告如下。

关键词： Aged and inpatients   Comorbidity   Hospital mortality   Nervous system diseases   Risk factors  

摘要： Background: Neurological disorders (NDs) are associated with high hospital mortality. We aimed to identify predictors of hospital mortality among elderly inpatients with NDs. Methods: Patients aged ≥60 years admitted to the hospital between January 1, 2009 and December 31, 2010 with acute NDs, chronic NDs as underpinnings of acute clinical disorders, and neurological complications of other diseases were studied. We analyzed demographic data, NDs, and comorbidities as independent predictors of hospital mortality. Logistic regression was performed for multivariable analysis. Results: Overall, 1540 NDs and 2679 comorbidities were identified among 798 inpatients aged ≥ 60 years (mean 75.8±9.1). Of these, 54.5% were female. Diagnostic frequency of NDs ranged between 0.3% and 50.8%. Diagnostic frequency of comorbidities ranged from 5.6% to 84.5%. Comorbidities varied from 0 to 9 per patient (90% of patients had ≥2 comorbidities), mean 3.2±1.47(CI, 3.1-3.3). Patients with multimorbidities presented with a mean of 4.7±1.7 morbidities per patient. Each ND and comorbidity were associated with high hospital mortality, producing narrow ranges between the lowest and highest incidences of death (hospital mortality = 18%) (95% CI, 15%-21%). After multivariable analysis, advanced age (P<0.001) and low socioeconomic status (P=0.003) were recognized as predictors of mortality, totaling 9% of the variables associated with hospital mortality. Conclusion: Neither a particular ND nor an individual comorbidity predicted hospital mortality. Age and low socioeconomic class accounted for 9% of predictors. We suggest evaluating whether functional, cognitive, or comorbidity scores will improve the risk model of hospital mortality in elderly patients admitted with ND. © 2018 Bacellar et al.