关键词： 一稿两投   《临床神经病学杂志》  

摘要： 为维护本刊声誉和广大读者的利益,现对一稿两投和一稿两用问题的处理声明如下:(1)本声明中所涉及的文稿均指原始研究的报告或尽管2篇文稿在文字的表达和讨论的叙述上可能存在某些不同之处,但这些文稿的主要数据和图表是相同的。所指文稿不包括重要会议的纪要、学位论文、疾病的诊断标准和防治指南、有关组织达成的共识性文件、新闻报道类文稿以及在一种刊物发表过摘要或初步报道而将全文投向另一种期刊的文稿。上述各类文稿如作者要重复投稿,应向有关期刊编辑部作出说

关键词： Japanese encephalitis   JE   JE virus   JE vaccine   Japanese encephalitis vaccine   Travel medicine   Traveller  

摘要： Background: Japanese encephalitis (JE), caused by the mosquito-borne JE virus, is a vaccine-preventable disease endemic to much of Asia. Travellers from non-endemic areas are susceptible if they travel to a JE endemic area. Although the risk to travellers of JE is low, the consequences may be severe. Methods: Here, we describe three cases of JE in British travellers occurring in 2014-15. In addition, we report, through interviews with survivors and their families, personal experiences of life after JE. Results: Three cases of JE were diagnosed in British travellers in 2014/15. One was acquired in Thailand, one in China and one in either Thailand, Laos or Cambodia. All three patients suffered severe, life-threatening illnesses, all were admitted to intensive care units and required medical evacuation back to the UK. One patient suffered a cardiac arrest during the acute stage but made a good recovery. The other two patients remain significantly paralysed and ventilator dependent. All three cases had clear indications for vaccination, and all have been left with life-changing neurological sequelae. Conclusions:Travel health providers should be aware of the severity of JE, as well as the risk, allowing travellers to make fully informed decisions on JE vaccination.

摘要： MEMBER LIST OF THE SEVENTH EDITORIAL BOARD OF JOURNAL OF CLINICAL NEUROLOGY 总 编 辑张颖冬 副总编辑 (按姓氏拼音顺序)陈生弟 郭述苏 洪 震 贾建平 刘春风 王 柠王小姗 徐 运 朱遂强

关键词： PBL   LBL   神经内科   临床规培   应用效果  

摘要： 目的探究分析PBL联合神经病学总论LBL教学模式在神经内科临床规培学员中的应用效果。方法选取我院进入神经内科临床规培学员60名,随机分为传统组(n=30)和联合组(n=30),传统组采用传统教学模式,联合组采用PBL联合神经病学总论LBL教学模式。对比两组教学效果。结果联合组学员的实践考核成绩、理论考核成绩、综合成绩均高于传统组,差异有统计学意义(P<0.05)。结论在神经内科临床规培学员中采用PBL联合神经病学总论LBL教学模式教学,学员的理论实践成绩均显著提高,教学效果显著,值得推广运用。

关键词： Acute subdural hemorrhage   Thrombin   Neurotoxicity   Argatroban   PAR1   SCH79797  

摘要： BackgroundAcute subdural hemorrhage (ASDH) is a severe consequence of traumatic brain injury. The occurrence of subdural blood increases the lethality of these patients independent of the amount of blood or elevated intracranial pressure. Thrombin is one of the potential harmful blood components. Possible harmful effects of thrombin are mediated via the Protease-activated-receptor-1 (PAR1) and thus, translating the acute Thrombin release after ASDH into cell loss. The objectives of the present study were twofold, namely to examine (1) the impact of direct thrombin inhibition in the acute phase after hemorrhage on the long-term histological and functional deficits and (2) the early inhibition of PAR1 activation by thrombin with the selective antagonist SCH79797 on lesion volume at 14days after ASDH. The effects of thrombin on the lesion size were investigated in two separate experiments via (1) direct thrombin inhibition in the subdural infused blood (Argatroban 600 mu g) as well as by (2) intraventricular injection ofthe PAR-1 antagonistSCH79797 (1 mu g or 5 mu g). Lesion volume and behavior deficits using a neurological deficit score and a motor function test (beam balance test) were analyzed as outcome parameters at 14days after ***59 Male Sprague-Dawley rats received a subdural infusion of 300 mu l autologous blood or sham operation. Lesion volume at 14days after ASDH tended to be smaller in the Argatroban-treated group when compared to the vehicle group (8.11.1 vs. 10.1 +/- 2.3mm(2), n.s.). Motor deficits in the beam balance test were not significantly less severe in the Argatroban-treated group. Animals treated with SCH79797 also showed a trend towards dose-dependent decreased lesion volume in comparison to the vehicle-treated group (1g: 4.3 +/- 0.7mm(3);5g: 3.8 +/- 1.1mm(3);vehicle: 6.5 +/- 2.0mm(3), n.s).Conclusions Thrombin inhibition in the subdural blood and local cerebral blockade of PAR-1 cause a tendency towards reduced lesion volume or funct

关键词： Biomarker   MicroRNA   real-time polymerase chain reaction   Subarachnoid hemorrhage   Stroke  

摘要： Objective: MiRNAs are important regulators of translation and have been described as biomarkers of a number of cardiovascular diseases, including stroke. The purpose of the study was to determine expression levels of serum miR-1297 in patients with aneurysmal subarachnoid hemorrhage (aSAH), and to assess whether miR-1297 was the prognostic indicator of aSAH. Methods: We treated 128 aSAH patients with endovascular coiling. The World Federation of Neurological Surgeons (WFNS) grades, Hunt-Hess grades, and modified Fisher scores were used to assess aSAH severity. Neurologic outcome was assessed using the Modified Rankin Scale (mRS) at 1-year post-aSAH. Serum was taken at various time points (24, 72, and 168 h, and 14 days). Serum samples from aSAH patients and healthy controls were subjected to reverse transcription (RT) quantitative real-time PCR (RT-qPCR). Results: A poor outcome at 1 year was associated with significantly higher levels of miR-1297 value at the four time points, higher WFNS grade, higher Hunt-Hess grade, and higher Fisher score. Serum miR-1297 levels were significantly higher in patients, compared with healthy controls. There were significant correlations of miR-1297 concentrations in serum with severity in aSAH. The AUCs of miR-1297 at the four time points for distinguishing the aSAH patients from healthy controls were 0.80, 0.94, 0.77, and 0.59, respectively. After multivariate logistic regression analysis, only miR-1297 at 24 and 72 h enabled prediction of neurological outcome at 1 year. Conclusion: Serum was an independent predictive factor of poor outcome at 1 year following aSAH. This result supports the use of miR-1297 in aSAH to aid determination of prognosis.