关键词： fragile X syndrome   metformin   autism spectrum disorders   protein synthesis   mTOR   ERK  

摘要： Fragile X syndrome (FXS) is the most frequent inherited form of intellectual disability and autism spectrum disorder. Loss of the fragile X mental retardation protein, FMRP, engenders molecular, behavioral, and cognitive deficits in FXS patients. Experiments using different animal models advanced our knowledge of the pathophysiology of FXS and led to the discovery of many targets for drug treatments. In this review, we discuss the potential of metformin, an antidiabetic drug approved by the US Food and Drug Administration, to correct core symptoms of FXS and other neurological disorders in humans. We summarize its mechanisms of action in different animal and cellular models and human diseases.

关键词： 《中国神经免疫学和神经病学杂志》   稿件处理系统  

摘要： 由于本刊原网址及投稿系统:www. cjnnnct. com和www. ncuroimmunol. com使用时间较久,且无法得到有效升级维护,已不能满足目前广大作者、审稿专家以及编辑部的使用要求,故决定停止使用原网址及投稿系统的使用,并于2018年2月正式启用了新的网址及投稿系统,新的稿件处理系统网址为:www. zsmb. cbpt. cnki. net。敬请广大新老作者、读者以及

关键词： Amyloid   alzheimer disease   gene expression   single-cell analysis   drug discovery   cell line  

摘要： Background: Identifying effective candidate drug compounds in patients with neurological disorders based on gene expression data is of great importance to the neurology field. By identifying effective candidate drugs to a given neurological disorder, neurologists would (1) reduce the time searching for effective treatments;and (2) gain additional useful information that leads to a better treatment outcome. Although there are many strategies to screen drug candidate in pre-clinical stage, it is not easy to check if candidate drug compounds can also be effective to human. Objective: We tried to propose a strategy to screen genes whose expression is altered in model animal experiments to be compared with gene expressed differentially with drug treatment to human cell lines. Methods: Recently proposed tensor decomposition (TD) based unsupervised feature extraction (FE) is applied to single cell (sc) RNA-seq experiments of Alzheimer's disease model animal mouse brain. Results: Four hundreds and one genes are screened as those differentially expressed during A beta accumulation as age progresses. These genes are significantly overlapped with those expressed differentially with the known drug treatments for three independent data sets: LINCS, DrugMatrix, and GEO. Conclusion: Our strategy, application of TD based unsupervised FE, is useful one to screen drug candidate compounds using scRNA-seq data set.

关键词： 参与式教学法   神经病学   临床教学   应用效果  

摘要： 目的探析在神经病学临床教学过程中应用参与式教学理念引导下的带教方案的临床效果。方法取2016～2018年到本院神经内科实习的医学生60例为分析对象,应用随机数字表方式将实习医学生进行分组,各组有30例,为常规组(常规神经内科临床见习教学)与实验组(参与式教学理念临床见习教学),通过评价两组学生相关临床数据以归纳参与式教学法的临床效果。结果从以下方面对两组学生教学知识掌握程度进行考核:理论知识、记忆理解以及临床分析,实验组学生考核所得评分均显著优于常规组(P<0.05);通过教学质量调查问卷以了解两组学生对所接受教学模式的评价,实验组学生对教学内容肯定评价显著高于常规组(P<0.05)。结论在神经病学临床教学中采取参与式教学法带教方案能够保障学生更好的掌握知识,同时对整体教学质量也有积极影响,值得临床推广。

关键词： Inertial MEMS   Piezoresistive   Wearable   Microaccelerometer   Neurological  

摘要： Inertial MEMS sensors having high performance play a key role in several biomotion applications. However, in addition to high performance, there is a demand for wearable sensors in medical diagnostic purposes to be of small size and light weight. Tremor (2-18 Hz) and Seizure (0.5-29 Hz) occurs in patients suffering from several neurological disorders having acceleration value from almost 0 g signifying fall to maximum +/- 6 g signifying jerks. In order to capture such low g signals, reduced cross axis sensitivity is required, which is still a challenge in the available ones. This paper presents the design and analysis of such a wearable microaccelerometer of piezoresistive type for the diagnosis of neurological disorders having an area of about 25 mm(2) and mass of around 6 mg. The sensitivity obtained for a dynamic range of +/- 6 g is 0.33 mV/V/g, noise floor is 7.65 mu g/root Hz and cross axis sensitivity is 0.48%. (C) 2018 Elsevier GmbH. All rights reserved.

关键词： 《临床神经病学杂志》   第一作者  

摘要： 1.请打开本刊网址(http://***),点击"投稿及审稿办公系统",进行在线注册。2.注册后登录系统,并以第一作者的中文姓名在线提交稿件(请勿以通讯作者或姓名拼音提交稿件)。3.在网站首页下载中心下载《版权转让确认书》,签字并加盖公章后拍照或扫描成电子版发至2105933141@***,并在邮件主题中注明"第一作者姓名"及"投稿"字样,如"张三-投稿"。4.不需要邮寄纸质材料。《临

关键词： Co-exposure   hexavalent chromium (VI)   nickel (II)   acetylcholinesterase (AChE)   chromium-electroplater  

摘要： BACKGROUND: Metal co-exposure of human subjects is an important matter of public health concern. It has been shown that Acetylcholinesterase activity is a suitable biomarker for the neurological risk assessment of some metals. A few studies have reported neurotoxicity risk among humans in co-exposure to chromium and nickel. OBJECTIVE: In this study, AChE activity was assessed in occupational exposure to chromium (VI) and co-exposure to nickel (II) and chromium (VI). METHODS: Air sampling was done in chromium electroplating workshops with the NIOSH 7600 and OSHA ID-121 methods for chromium and nickel assessment. Thirty-two workers from hard chromium plating and 30 from decorative chromium plating were evaluated, while AChE activity was measured by the Elman method. RESULTS: Personal exposure to chromium in 20% of the studied people exceeded the TWA set by ACGIH. Occupational exposure to nickel in 47% of the DCP subjects was found to be higher than TWA. Cholinergic inhibition in plating workers was marked by a decrease in AChE compared to controls. Subjects with chromium (VI) exposure contained significantly higher inhibition of AChE activity (p < 0.001) than workers with co-exposure to nickel (II) and chromium (VI). CONCLUSIONS: The chromium-matched electroplaters have no significant difference in AChE activity. It can be concluded that cholinergic inhibition with chromium (VI) is higher than nickel (II) exposure.

关键词： 版面费   《中国神经免疫学和神经病学杂志》  

摘要： 近期,有不法分子以本刊名义收取作者审稿费和版面费,损害了广大作者的利益,造成了极其不良的影响,希望广大投稿作者提高警惕,谨防上当受骗。本刊编辑部特此严正声明:(1)我刊为卫计委主管、北京医院和中国免疫学会神经免疫分会共同主办的学术性刊物,官方投稿网站为http://***,无任何其他投稿、采编方式;(2)投稿成功后,一般会经过"初审-退作者修改-复审-退作者修改-录用"等过程,此过程均通过本刊官网投稿系统中进行,如作者在投稿后3个月

关键词： 投稿系统   编辑部  

摘要： 由于本刊原投稿系统:***和***使用时间较久,且无法得到有效升级,不能满足目前广大作者、审稿专家以及编辑部的使用要求,故决定停止使用原投稿系统,并于2018年2月正式启用了新的投稿系统,新投稿网址为:***。请广大新老作者通过新投稿系统进行投稿,如投稿过程中存在任何问题,请及时联系编辑部。

关键词： 中国神经免疫学和神经病学杂志   神经病学   神经免疫学  

摘要： 《中国神经免疫学和神经病学杂志》是全国惟一与神经免疫学相关的神经病学学术性期刊,由国家卫生健康委员会主管,北京医院、中国免疫学会神经免疫分会主办,国内外公开发行。本刊以从事神经免疫学和神经病学临床和科研人员等为主要读者对象,报道神经疾病领域尤其是神经免疫学领域的科研成果。本刊属中国科技论文统计源期刊、中国科技核心期刊、北大核心期刊、中国科技引文数据库来源期刊与中国学术期刊综合评价数据库来源期刊等。