关键词： 《临床神经病学杂志》   作者姓名   第一作者   版面费  

摘要： 《临床神经病学杂志》系国家级神经病学专业性学术刊物,由南京医科大学附属脑科医院主办。刊登内容以临床神经病学为主,兼及有关边缘学科。读者对象以从事临床神经病学专业的高、中级人员为主,也可供内科、儿科、眼科、五官科医师参阅。本刊的办刊宗旨是:面向临床,面向基层,注重实用,鼎力于提高我国临床神经科医师的专业理论及诊疗水平。

摘要： B Background: b In the past decade there has been a focus on uncovering the genetic contribution to complex diseases - including psychiatric and neurodegenerative disorders - and genome wide association studies (GWAS) have identified robust associations with these disorders. B Methods: b Polygenic risk scores (PRS) were generated for individuals included in both brain (total n = 2,300 samples) and blood (total n = 5,700 samples) datasets with matched genetic and DNA methylation data. Epigenome-wide association study (EWAS) analyses were performed in R, using the PRS, quantifying genome-wide patterns of DNA methylation associated with polygenic burden separately in each dataset. [Extracted from the article]

关键词： MeIIg   Methylmercury   Neurological alteration   Clinical evidence   Mercury   CNS disorder  

摘要： The mercury-related central nervous system disorders have been extensively studied on animal models and human beings. However, clinical evidences of which neurological changes are in fact associated with mercury exposure remains controversial. This systematic review (Prospero registration under the number CRD42016041760) aimed to elucidate the association of methylmercury (MeHg) exposure with neurological alteration in populations living in MeHg-endemic risk area. A systematic search was performed according to the Preferred Reporting Items for Systematic Review and Meta-Analysis criteria using available databases PubMed, LILACS, Scopus, Web of Science, The Cochrane Library, OpenGrey and Google Scholar. A search of the following terms: "methylmercury compounds", "organomercury compounds", "neurologic manifestations", "memory disorders", "neurobehavioral manifestations" and "communication disorders" were performed in a systematic way. Studies focusing on MeHg exposure and subsequent neurological alteration on humans (> 13 years) were included. Evaluation of methodological quality and risk of bias as well as the level of evidence was performed. Our results have identified 470 studies and six articles were eligible for systematic review inclusion criteria. The studies suggested alterations related to the psychosensory, motor and coordination system, as well as motor speech, hearing, visual impairment, mood alterations and loss of intelligent quotient. Of all the six studies, two presented a high risk of bias, with methodological problems related to the confounding factors and all studies presented evidence level ranged from very low to low. In this way our results revealed that a definitive demonstration of an association of MeHg and neurological alterations in human beings is still a pending subject. Future studies in this topic should take into consideration more confident and reliable methods to answer this question.

关键词： Spinal cord injury   Wnt-3a   Wnt/beta-catenin signaling pathway   Neuroprotection   Axon regeneration   Autophagy   Apoptosis   Mammalian target of rapamycin signaling pathway  

摘要： Background: Spinal cord injury (SCI) is a constant challenge in medical research and a global therapeutic problem. Treatment of this condition remains difficult in clinical practice. Hence, prevention, treatment, and rehabilitation of SCI have become imminent tasks in the medical field. Summary: Recent evidence suggest the important role of Wnt/beta-catenin signaling pathway, a canonical Wnt signaling pathway, in neural development, axon guidance, neuropathic pain relief, and neuronal survival. Wnt-3a is regarded as an activator of the canonical Wnt signaling pathway. This activator is expressed in the dorsal midline region and is responsible for spinal cord development. In addition, Wnt-3a plays a regulatory role in autophagy, apoptosis, and regeneration of neurons;neurogenic inflammation;and axon regeneration. Herein, we demonstrated that neuronal autophagy was regulated by Wnt-3a via beta-catenin and mammalian target of rapamycin signaling pathways after SCI. Our study also discovered that the Wnt-3a provided a favorable microenvironment for the recovery of nerve function after SCI. Key Messages: This study systematically elaborates the neuroprotective effect of Wnt-3a and its neuroprotection molecular mechanism after SCI. This study provides a new molecular mechanism and research basis for clinical treatment of SCI. (C) 2019 S. Karger AG, Basel

关键词： 神经病学   神经内科   教学实践模式   创新  

摘要： 因为人体的神经系统具有非常强的复杂性以及重要性,因此,神经病学在医学各个学科当中具有着举足轻重的地位.从本质上而言,神经病学是一门具有非常强理论研究性以及实践性的综合应用型学科.因为神经类的疾病的具体表现形式是非常非常复杂的,具有多样性,因此,这就要求其相关医生不仅仅要掌握较高的理论基础,还应该掌握高超的医疗技能以及丰富的临床经验等等.相信很多人都知道,医学类学生在不可能直接走到工作岗位单独进行诊断,而是要经历实习阶段,我们也可以说实习阶段是学生到医生的过度阶段,然而传统的实习模式随着时代的发展弊端愈发明显,所以,新的神经内科实习模式早已成为我国医疗体系当中不可或缺的重要组成内容

摘要： 《临床神经病学杂志》系国家级神经病学专业性学术期刊。国内统一刊号CN 32-1337/R,国际标准刊号ISSN 1004-1648。曾荣获第二届全国优秀科技期刊奖及连续多次江苏省优秀期刊奖,并已入选中文核心期刊及中国科技核心期刊。2005年、2006年先后被美国化学文摘(CA)、俄罗斯文摘杂志(РЖ)、波兰哥白尼索引(IC)以及美国《乌利希国际期刊指南》四大数据

关键词： Brain banking   Non-neurological controls   MRI   Neuropathology  

摘要： Well-characterized, high-quality brain tissue of non-neurological control subjects is a prerequisite to study the healthy aging brain, and can serve as a control for the study of neurological disorders. The Normal Aging Brain Collection Amsterdam (NABCA) provides a comprehensive collection of post-mortem (ultra-)high-field MRI (3Tesla and 7 Tesla) and neuropathological datasets of non-neurological controls. By providing MRI within the pipeline, NABCA uniquely stimulates translational neurosciences;from molecular and morphometric tissue studies to the clinical setting. We describe our pipeline, including a description of our on-call autopsy team, donor selection, in situ and ex vivo post-mortem MRI protocols, brain dissection and neuropathological diagnosis. A demographic, radiological and pathological overview of five selected cases on all these aspects is provided. Additionally, information is given on data management, data and tissue application procedures, including review by a scientific advisory board, and setting up a material transfer agreement before distribution of tissue. Finally, we focus on future prospects, which includes laying the foundation for a unique platform for neuroanatomical, histopathological and neuro-radiological education, of professionals, students and the general (lay) audience.

关键词： 版面费  

摘要： 近期,有不法分子以本刊名义收取作者审稿费和版面费,损害了广大作者的利益,造成了极其不良的影响,希望广大投稿作者提高警惕,谨防上当受骗。本刊编辑部特此严正声明:(1)我刊为卫计委主管、北京医院和中国免疫学会神经免疫分会共同主办的学术性刊物,官方投稿网站为http://***,无任何其他投稿、采编方式;(2)投稿成功后,一般会经过"初审-退作者修改-复审-退作者修改-录用"等过程,此过程均通过本刊官网投稿系统中