关键词： 临床神经病学   杂志   稿约   学术刊物   医科大学   边缘学科   办刊宗旨   国家级  

摘要： 《临床神经病学杂志》系国家级神经病学专业性学术刊物,由南京医科大学附属脑科医院主办。刊登内容以临床神经病学为主,兼及有关边缘学科。读者对象以从事临床神经病学专业的高、中级人员为主,也可供内科、儿科、眼科、五官科医师参阅。本刊的办刊宗旨是:面向临床,面向基层,注重实用,鼎力于提高我国临床神经科医师的专业理论及诊疗水平。

关键词： telehealth   telemedicine   teleneurology   telepsychiatry   behavioral health  

摘要： Neurological conditions affect one-third of Americans and are some of the most prevalent health issues in the country. Many sufferers have difficulty accessing treatment, however, advances in technology may be able to support availability, affordability, and convenience of care through telehealth services. This review outlines the current state of telemedicine in neurological healthcare, highlighting evidence-based research and use cases for digital services. Details on expenses associated with managing certain well-known conditions are included to shed light on the financial burden of disease and how telehealth can contribute to cost savings for patients and providers. Finally, a discussion of current telehealth legislature gives additional perspective on regulatory dynamics experienced by different stakeholders in the field. Research supports telemedicine as a solution to enhance current care models given its many benefits, including efficient and clinically useful service delivery. This movement has the opportunity to help billions of individuals globally by acting as a mechanism to provide impactful and scalable neurological healthcare.

关键词： 糖尿病   疼痛   神经病学表现   疾病模型,动物   链脲佐菌素   趋化因子配体3  

摘要： 目的探讨脊髓趋化因子配体3(CCL3)在链脲佐菌素(STZ)诱导大鼠糖尿病神经病理性疼痛模型中的作用。方法将SD大鼠随机分成对照组和STZ组。STZ组进一步分为CCL3组、IgG2A组,以及A438079组、PBS组,STZ注射前1 d经鞘内注射CCL3和A438079,1次/d,持续7 d。采用免疫组织化学法检测大鼠脊髓背角(SDH)Iba1的表达,实时荧光定量聚合酶链反应检测CCL3及其受体CCR1、CCR5和P2X7R mRNA表达水平,von Frey细丝法测定大鼠机械痛阈值。结果大鼠腹腔注射STZ后机械刺激痛阈降低(P<0.05)。大鼠SDH小胶质细胞数量增加(P<0.05)。与此同时,STZ组大鼠SDH中CCL3、CCR5 mRNA表达增加(P<0.05)。鞘内注射CCL3中和抗体能减轻STZ诱导的大鼠机械性痛觉过敏(P<0.05)。P2X7R选择性拮抗剂A438079能缓解STZ所致痛觉过敏(P<0.05)。结论大鼠SHD中CCL3和P2X7R有助于STZ诱导的痛觉过敏。

关键词： 《中文核心期刊要目总览》   文献计量学   出版周期   神经疾病   研究人员   专家评审   精神病学   神经病学  

摘要： 《中国现代神经疾病杂志》主编:我们谨此郑重通知:依据文献计量学的原理和方法,经研究人员对相关文献的检索、统计和分析,以及学科专家评审,贵刊《中国现代神经疾病杂志》入编《中文核心期刊要目总览》2017年版(即第8版)之“神经病学与精神病学”类的核心期刊。该书由北京大学出版社出版。书中按《中国图书馆分类法》的学科体系,列出了78个学科的核心期刊表,并逐一对核心期刊进行了著录。著录项目包括:题名、并列题名、主办单位、创刊时间、出版周期、学科分类号、ISSN号、CN号、邮发代号、编辑部地址、邮政编码、电话、网址、电子邮箱、内容简介等。

关键词： 中西医结合学   首都医科大学   中西医结合儿科学   教学医院   附属医院   高等院校   神经病学   北京市  

摘要： 首都医科大学是北京市市属重点高等院校,2008年首都医科大学整合16家附属医院和教学医院,成立首都医科大学中西医结合学系,至今学系成员已增至21家单位.学系根据各附属医院及教学医院的特色分别在中西医结合肝病、中西医结合神经病学、中西医结合儿科学、中西医结合感染与重症医学等方向具有强大的研究实力,形成了北京市乃至全国规模最大也是最具活力的中西医结合力量之一。

关键词： 客观结构化临床考试   神经病学   实习教学  

摘要： 目的探讨结合客观结构化临床考试(OSCE)目标进行神经病学实习教学设计和考核的可行性。方法选择昆明医科大学临床医学系2012级本科神经内科实习生108人,随机分为两组,试验组结合OSCE目标进行神经病学实习教学设计和考核,对照组进行传统教学,比较两组对实习效果的评价。结果 OSCE结果显示,试验组病史采集、体格检查、辅助检查、病例分析和治疗选择站点考核成绩显著高于对照组。在深化对理论知识的掌握、提高临床操作技能、培育正确的职业观与提高医患沟通能力、提高学习兴趣方面,试验组对实习效果的评价高于对照组。结论结合OSCE目标进行神经病学实习教学设计和考核,有助于提高学生学习自主性与教学质量,值得推广。

关键词： Organ donation   Biomarker   Clinical trial   Transplantation   Risk prediction   Brain death  

摘要： Purpose: We sought to build prediction models for organ transplantation and recipient survival using both biomarkers and clinical information. Materials and methods: We abstracted clinical variables from a previous randomized trial (n - 556) of donor management. In a subset of donors (n = 97), we measured two candidate biomarkers in plasma at enrollment and just prior to explantation. Results: Secretory leukocyte protease inhibitor (SLPI) was significant for predicting liver transplantation (C-statistic 0.65 (0.53, 0.78)). SLPI also significantly improved the predictive performance of a clinical model for liver transplantation (integrated discrimination improvement (IDI): 0.090 (0.009. 0.210)). For other organs, clinical variables alone had strong predictive ability (C-statistic >0.80). Recipient 3-years survival was 80.0% (71.9%, 87.0%). Donor IL-6 was significantly associated with recipient 3-years survival (adjusted Hazard Ratio (95%CI): 126(1.08, 1.48), P .004). Neither clinical variables nor biomarkers showed strong predictive ability for 3-year recipient survival. Conclusions: Plasma biomarkers in neurologically deceased donors were associated with organ use. SLPI enhanced prediction within a liver transplantation model, whereas IL-6 before transplantation was significantly associated with recipient 3-year survival. (C) 2018 Elsevier Inc. All rights reserved.

关键词： Genetic polymorphism   Glutathione S-tranferases   Neurological disorders  

摘要： Glutathione S-tranferases (GSTs) are phase II drug metabolizing enzymes, they play crucial role in detoxification of environmental pollutants, carcinogens, drugs, xenobiotics and oxidative stress products. Genetic differences in expression and activity of GSTs are due to the existence of polymorphic alleles which encode them. Because of genetic polymorphism the GST activity has altered that lead to the increased susceptibility for toxic chemical compounds. GST genetic polymorphism is the main reason for many neurological dysfunctions. GST has over expressed in epileptic brain and pi (π) GST has used to predict stroke;mu (μ) and pi (π) GST are over expressed in Alzheimer's disease (AD). Null and single nucleotide polymorphism of GST has associated with many neurodisorders. Over all, it can be concluded that the GST genetic polymorphism has associated with neurodegenerative diseases. © 2018 Elsevier B.V.

关键词： Aneurysm expansion   Aneurysm growth   Flow diverter   Intracranial aneurysm   Neurological deficit  

摘要： OBJECTIVE: Patients with large and giant intracranial aneurysms (lAs) can experience neurological deterioration within 6 months after successful flow diverter (FD) placement. The purpose of the present study was to assess whether the occurrence of neurological deterioration can he linked to IA expansion within 6 months after FD treatment. METHODS: From 2010 to 2016, 45 FD procedures were performed in 44 patients with a large or giant IA. From this group, we selected all patients (14 patients with 15 lAs) with neurological deterioration within 6 months after FD treatment. All these patients had undergone follow-up imaging studies within the same period. The patients were then divided into 2 groups, those with mass effect-related and those with ischemia-related symptoms. The volumes of all treated lAs were determined through manual segmentation of the available pre- and postoperative imaging studies to determine IA expansion after FD treatment. To rule out false-positive findings, we only considered an IA volume increase of >20% after FD treatment as a true IA volume increase. RESULTS: During the follow-up period, 6 !As increased in volume and 9 lAs did not. More patients presenting with mass effect-related symptoms showed IA expansion (6 of 10 lAs) compared with patients presenting with ischemia-related symptoms (0 of 5 lAs;Fisher's exact test, 2-sided;P = 0.044). CONCLUSION: The volume of large and giant lAs can increase in the first 6 months after FD treatment. More patients presenting with mass effect-related symptoms showed IA expansion than patients with ischemia-related symptoms.

关键词： graduate medical education   qualitative inquiry   quality improvement  

摘要： The goal of medical residency programs is to provide educational opportunities to residents to facilitate their transformation into independent and competent health care practitioners. Despite an abundance of quantitative data on resident performance, qualitative data are lacking in published literature. Our study involved a standardized interview with all graduating child neurology residents to better understand their educational experiences during training. Qualitative data analysis resulted in 5 basic themes experienced by all trainees: (1) appreciation for faculty supportiveness, (2) appreciation for faculty receptiveness to feedback, (3) the difficulty of balancing clinical and academic demands during residency, (4) the benefit of structured mentorship and research, and (5) the value of independent and experiential learning. Our findings demonstrate that qualitative inquiry can be used to better understand the educational experience of child neurology residents. The themes identified through this qualitative analysis were useful targets for programmatic quality improvements.