关键词： 神经病学教育   翻转课堂   混合式学习   小组学习   案例教学   临床本科教学  

摘要： 目的研究并评价混合式学习模式在神经病学见习教学中的效果。方法选择2015-2016学年期间在昆明医科大学第二附属医院进行见习的临床医学专业本科学生193人,分为两组。实验组(n=96)采取混合式学习模式进行神经病学病史采集和体格检查见习,此模式整合了翻转课堂、小组学习、基于病例学习等主动学习形式。对照组(n=97)继续原有的见习教学模式。比较实验组和对照组学生的病史采集和体格检查的通过率和成绩,调查学生对于混合式学习模式的评价。结果实验组在病史采集、体格检查通过率均优于对照组。学生评价显示,混合式学习模式有助于神经系统病史采集和体格检查的学习。结论混合式学习模式有益于提高神经病学见习收效,得到学生好评,值得进一步推广。

关键词： 神经病学   神经系统变性病   炎性脱髓鞘病   中枢神经系统   神经肌肉病   脑血管病   帕金森病  

摘要： 2018年是神经病学各项研究取得丰硕成果的一年。这一年,脑血管病、神经系统变性病、帕金森病、癫痫、中枢神经系统炎性脱髓鞘病、神经肌肉病、头痛等领域均有很多进展和发现,本文对2018年神经病学研究进展进行盘点、总结。

摘要： 《国际神经病学神经外科学杂志》创刊于1974年,由教育部主管,中南大学主办,中南大学湘雅医院承办。是目前国内。唯一一本同时涵盖神经病学和神经外科学两个相联学科的专业学术期刊。本刊为中国科技核心期刊(中国科技论文统计源期刊)。

关键词： PBL   积极性   动手能力   讨论式学习   开拓性人才   神经病学教学  

摘要： 神经病学内容繁多、枯燥、深邃且抽象,对学生的动手能力和分析问题的能力要求很高,传统教学难以调动学生们学习的积极性,不利于提高学生们自主解决问题的能力,难以提高神经病学的教学质量。PBL教学模式是一种开放式的教学模式,是基于现实世界的以学生为中心、以教师为引导的教学模式,其实质是以学生自主学习为中心的小组讨论式学习,其优势和重点是充分调动学生们学习的积极性,令学生不断发现新问题,启发学生自主解决问题,从而培养学生们解决现实问题的能力。在神经病学的教学中,开展PBL教学模式能有效培养出更多具备理论创新和解决临床实际问题能力的开拓型复合人才。

关键词： 《中文核心期刊要目总览》   文献计量学   脑血管病   研究人员   专家评审   精神病学   神经病学   北京大学  

摘要： 《中国脑血管病杂志》主编:我们谨此郑重通知:依据文献计量学的原理和方法,经研究人员对相关文献的检索、统计和分析,以及学科专家评审,贵刊《中国脑血管病杂志》入编《中文核心期刊要目总览》2017年版(即第8版)之“神经病学与精神病学”类的核心期刊。该书由北京大学出版社出版。

关键词： assessment tools   clinical outcomes   clinical research   common data elements   data sets   traumatic brain injury  

摘要： Through a partnership with the National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, and Department of Defense, the development of Sport-Related Concussion (SRC) Common Data Elements (CDEs) was initiated. The aim of this collaboration was to increase the efficiency and effectiveness of clinical research studies and clinical treatment outcomes, increase data quality, facilitate data sharing across studies, reduce study start-up time, more effectively aggregate information into metadata results, and educate new clinical investigators. The SRC CDE Working Group consisted of 32 worldwide experts in concussion from varied fields of related expertise divided into three Subgroups: Acute (<72h post-concussion), Subacute (3 days-3 months post-concussion) and Persistent/Chronic (>3 months post-concussion). To develop CDEs, the Subgroups reviewed various domains, then selected from, refined, and added to existing CDEs, case report forms and field-tested data elements from national registries and funded research studies. Recommendations were posted to the NINDS CDE Website for Public Review from February 2017 to April 2017. Following an internal Working Group review of recommendations, along with consideration of comments received from the Public Review period, the first iteration (Version 1.0) of the NINDS SRC CDEs was completed in June 2017. The recommendations include Core and Supplemental-Highly Recommended CDEs for cognitive data elements and symptom checklists, as well as other outcomes and end-points (e.g., vestibular, oculomotor, balance, anxiety, depression), and sample case report forms (e.g., injury reporting, demographics, concussion history) for domains typically included in clinical research studies. The NINDS SRC CDEs and supporting documents are publicly available on the NINDS CDE website ***. Widespread use of CDEs by researchers and clinicians will facilitate consistent SRC clinical res

关键词： adjudin   AQP4   neuroinflammation   NF-kappa B   TBI  

摘要： Adjudin, a small molecular compound that is used as a male contraceptive, has been reported to play a neuroprotective role in an ischemic stroke injury model. However, its effect on traumatic brain injury (TBI) has not been assessed. Hence, we investigated the effects of adjudin on cerebral edema using a mouse model of TBI and explored the underlying mechanisms. Adult male C57BL/6 mice received controlled cortical impact (CCI) injury, then an injection of adjudin (50 mg/kg). The mice were euthanized 3 days post-CCI injury, and samples were collected for further analysis. Cultured primary mouse astrocytes were used for in vitro experiments. Adjudin treatment significantly attenuated cerebral edema on Day 3 and improved neurobehavioral outcomes on Days 3, 7, and 14 after CCI injury, compared with the vehicle group. Additionally, the evaluation of Evans blue extravasation and expression of tight junction proteins demonstrated remarkable effects of adjudin on blood-brain barrier protection. Further, adjudin treatment significantly decreased the gene and protein expression of aquaporin 4 in post-injury mice and inhibited progression of neuroinflammation in both mice and cultured astrocytes. The Western blot results of the peritraumatic protein samples demonstrated that adjudin significantly blocked the phosphorylation of IKK alpha, I kappa B alpha/beta, and NF-kappa B p65, which resulted in a reduction of NF-kappa B p65 nuclear translocation. In conclusion, adjudin attenuated the development of TBI-induced cerebral edema at least partly via anti-inflammatory effects and inhibition of the NF-kappa B pathway. These findings suggest that adjudin is a potential therapeutic intervention preventing the development of cerebral edema after TBI.

关键词： 神经病学与神经康复学杂志   证明文件   缩略词   投稿声明  

摘要： Information for authors《神经病学与神经康复学杂志》(CN:31-1927/R;ISSN:1672-7061)由上海市卫生和计划生育委员会主管,上海市中西医结合学会、上海交通大学医学院附属仁济医院主办,是国内外公开发行的神经病学与神经康复学领域的专业学术期刊,以神经科、神经康复科和精神科临床医师及相关领域的科研人员及在校师生为主要读者对象。

关键词： Neurological   Abnormality   Symptom   of   Familial   Hemophagocytic   Lymphohistiocytosis  

摘要： To the Editor:Hemophagocytic lymphohistiocytosis (HLH)is a life-threatening disease which impacts many parts of the body including the digestive,circulatory,and respiratory *** central nervous system (CNS)can also be affected,particularly in patients with familial HLH-2 (FHL-2),responsible for approximately 20% of all ***-2 is a result of mutations to the perforin 1 (PRF1)gene,which can occur at numerous sites on the gene.

关键词： 临床实践   神经病学   留学生   角色扮演   角色互换  

摘要： 为提高留学生《神经病学》临床教学质量,在留学生临床实践教学中开展"角色扮演和角色互换"教学法。结果显示,该教学法可以提高学生学习兴趣、巩固理论知识、提高临床技能,总体教学效果良好,值得推广。