摘要： MEMBER LIST OF THE SEVENTH EDITORIAL BOARD OF JOURNAL OF CLINICAL NEUROLOGY 总 编 辑张颖冬 副总编辑 (按姓氏拼音顺序)陈生弟 郭述苏 洪 震 贾建平 刘春风 王 柠王小姗 徐 运 朱遂强

关键词： PBL   LBL   神经内科   临床规培   应用效果  

摘要： 目的探究分析PBL联合神经病学总论LBL教学模式在神经内科临床规培学员中的应用效果。方法选取我院进入神经内科临床规培学员60名,随机分为传统组(n=30)和联合组(n=30),传统组采用传统教学模式,联合组采用PBL联合神经病学总论LBL教学模式。对比两组教学效果。结果联合组学员的实践考核成绩、理论考核成绩、综合成绩均高于传统组,差异有统计学意义(P<0.05)。结论在神经内科临床规培学员中采用PBL联合神经病学总论LBL教学模式教学,学员的理论实践成绩均显著提高,教学效果显著,值得推广运用。

关键词： Acute subdural hemorrhage   Thrombin   Neurotoxicity   Argatroban   PAR1   SCH79797  

摘要： BackgroundAcute subdural hemorrhage (ASDH) is a severe consequence of traumatic brain injury. The occurrence of subdural blood increases the lethality of these patients independent of the amount of blood or elevated intracranial pressure. Thrombin is one of the potential harmful blood components. Possible harmful effects of thrombin are mediated via the Protease-activated-receptor-1 (PAR1) and thus, translating the acute Thrombin release after ASDH into cell loss. The objectives of the present study were twofold, namely to examine (1) the impact of direct thrombin inhibition in the acute phase after hemorrhage on the long-term histological and functional deficits and (2) the early inhibition of PAR1 activation by thrombin with the selective antagonist SCH79797 on lesion volume at 14days after ASDH. The effects of thrombin on the lesion size were investigated in two separate experiments via (1) direct thrombin inhibition in the subdural infused blood (Argatroban 600 mu g) as well as by (2) intraventricular injection ofthe PAR-1 antagonistSCH79797 (1 mu g or 5 mu g). Lesion volume and behavior deficits using a neurological deficit score and a motor function test (beam balance test) were analyzed as outcome parameters at 14days after ***59 Male Sprague-Dawley rats received a subdural infusion of 300 mu l autologous blood or sham operation. Lesion volume at 14days after ASDH tended to be smaller in the Argatroban-treated group when compared to the vehicle group (8.11.1 vs. 10.1 +/- 2.3mm(2), n.s.). Motor deficits in the beam balance test were not significantly less severe in the Argatroban-treated group. Animals treated with SCH79797 also showed a trend towards dose-dependent decreased lesion volume in comparison to the vehicle-treated group (1g: 4.3 +/- 0.7mm(3);5g: 3.8 +/- 1.1mm(3);vehicle: 6.5 +/- 2.0mm(3), n.s).Conclusions Thrombin inhibition in the subdural blood and local cerebral blockade of PAR-1 cause a tendency towards reduced lesion volume or funct

关键词： Biomarker   MicroRNA   real-time polymerase chain reaction   Subarachnoid hemorrhage   Stroke  

摘要： Objective: MiRNAs are important regulators of translation and have been described as biomarkers of a number of cardiovascular diseases, including stroke. The purpose of the study was to determine expression levels of serum miR-1297 in patients with aneurysmal subarachnoid hemorrhage (aSAH), and to assess whether miR-1297 was the prognostic indicator of aSAH. Methods: We treated 128 aSAH patients with endovascular coiling. The World Federation of Neurological Surgeons (WFNS) grades, Hunt-Hess grades, and modified Fisher scores were used to assess aSAH severity. Neurologic outcome was assessed using the Modified Rankin Scale (mRS) at 1-year post-aSAH. Serum was taken at various time points (24, 72, and 168 h, and 14 days). Serum samples from aSAH patients and healthy controls were subjected to reverse transcription (RT) quantitative real-time PCR (RT-qPCR). Results: A poor outcome at 1 year was associated with significantly higher levels of miR-1297 value at the four time points, higher WFNS grade, higher Hunt-Hess grade, and higher Fisher score. Serum miR-1297 levels were significantly higher in patients, compared with healthy controls. There were significant correlations of miR-1297 concentrations in serum with severity in aSAH. The AUCs of miR-1297 at the four time points for distinguishing the aSAH patients from healthy controls were 0.80, 0.94, 0.77, and 0.59, respectively. After multivariate logistic regression analysis, only miR-1297 at 24 and 72 h enabled prediction of neurological outcome at 1 year. Conclusion: Serum was an independent predictive factor of poor outcome at 1 year following aSAH. This result supports the use of miR-1297 in aSAH to aid determination of prognosis.

关键词： Transitional neurology care   Health care coordination   Adolescent health   Movement disorders   Epilepsy   Neuro-metabolic disorders  

摘要： Background: "JUMP" is a multidisciplinary program based at the Pitie-Salpetriere Hospital Paris that transitions young adults with chronic neurological conditions from paediatric to adult healthcare. Transitional care programs have been shown to improve medical, educational and psychosocial outcomes for adolescent patients. Methods: Demographic details and health-related variables of all patients referred to the JUMP program were collected. Satisfaction outcome measures were the 18-item On Your Own Feet Transfer Experience Scale (OYOF-TES) and a visual analogue scale, which assessed overall satisfaction with the transfer process. Scales were sent to JUMP patients attending the JUMP day hospital (n = 94) and their parents (n = 94). Results: Since its inception, 111 patients have been seen in the JUMP program. Nine neurological clinical syndromes and four main underlying etiologies were identified. Approximately half of all questionnaires and scales (86/188) sent to patients and parents were returned. Eighty-nine percent of patients and 91% of parents were very satisfied with their transfer experience. There was a strong, positive correlation between patient and parent satisfaction [r = 0.910;p < 0.0001]. Conclusion: The JUMP program which is rooted in a multidisciplinary and coordinated approach to transitional care encompasses a broad range of neuro-pathologies. Overall, satisfaction levels were high amongst patients within the program, and their parents. The key role played by the coordination nurse specialists throughout the transfer process is a likely key determinant in satisfaction levels.

关键词： TRPC6   Systemic lupus erythematous   Neuropsychiatric   Calcium   Apoptosis   Cytokines   Genetics  

摘要： Patients with systemic lupus erythematosus (SLE) carrying a TT genotype for the rs7925662 single nucleotide polymorphism (SNP) in the transient receptor potential canonical channel 6 (TRPC6) gene are more likely to develop neuropsychiatric manifestations (NPSLE). We functionally characterised the effects of TRPC6 on peripheral blood mononuclear cells from 18 patients with SLE and 8 healthy controls with a known genotype. TRPC6 influenced calcium currents, apoptosis rates and cytokine secretion in a disease- and genotype-dependent manner. Cells from TT patients with NPSLE were more dependent on TRPC6 for the generation of calcium currents.