关键词： Spinal tuberculosis   Thoracolumbar junction   Neurological deficit   Posterior decompression  

摘要： BackgroundA multicentre retrospective study was conducted to evaluate the safety and efficacy of single-stage posterior debridement, decompression and transpedicular screw fixation for the treatment of thoracolumbar junction (T12-L1) tuberculosis in patients with associated neurological *** junction (T12-L1) tuberculosis patients (n=69) with neurological deficit who underwent single-stage posterior debridement, decompression and transpedicular screw fixation from January 2005 to January 2015 were included in the study. Antituberculosis therapy was performed both before and after surgery. The surgery duration and patient blood loss were evaluated, in addition to the change in pain visual analogue score (pVAS), kyphotic angle, Oswestry disability index (ODI) score and American Spinal Injury Association (ASIA) grade assessed preoperatively, immediate postoperatively and at the final follow-up *** average blood loss was 354291mL. The average kyphosis angle was corrected from 21 +/- 9 degrees preoperatively to 9 +/- 4 degrees postoperatively, with a mean decrease in pVAS and ODI scores of 3.4 and 16, respectively. The postoperative ASIA grading was grade A for five patients, grade C for 15 and grade D for 49 patients, which had improved to grade C for four patients, grade D for three patients and grade E for 62 patients at the final follow-up. The neurological deficit did not worsen in any of the *** Single-stage posterior debridement, decompression and transpedicular screw fixation is an effective treatment method in thoracolumbar junction (T12-L1) tuberculosis patients with neurological deficit, with good neurological recovery and no progression of kyphosis.

摘要： Ethnopharmacological relevance: Viscum album L., commonly known as mistletoe, has been used for centuries in traditional medicine to treat various neurological diseases, including epilepsy, hysteria, nervousness, hysterical psychosis, dizziness and headaches. Aim of the study: The aim of this review is to summarize existing evidence confirming the influence of mistletoe on the central nervous system and to investigate the compounds that may be responsible for this activity. Materials and methods: Available information from studies of various species of the Viscum L. genus was collected from scientific journals, books, and reports via a library and an electronic data search (Elsevier, Google Scholar, PubMed, Springer, Science Direct, ResearchGate, and ACS). Results: The main chemical constituents of Viscum L. species are viscotoxins, lectins, flavonoids, phenolic acids, terpenoids, sterols, phenylpropanoids, and alkaloids. Various extracts of Viscum album L. showed central nervous system activity, including antiepileptic, sedative, antipsychotic, anxiolytic, antidepressant and antinociceptive effects in mice and rats. Additionally, the extracts increased the level of brain-derived neurotrophic factor, prevented apoptotic neuronal death induced by amyloid beta and weakly inhibited cholinesterase activity. Conclusions: Numerous historical references describe the use of mistletoe for the treatment of central nervous system disorders. In recent years, studies have started to confirm the antiepileptic, antipsychotic, sedative and antinociceptive effects of mistletoe. Additionally, mistletoe can be used as a complementary treatment for Alzheimer's disease. The therapeutic effect of mistletoe might be a result of the synergistic interactions of various secondary metabolites, including mistletoe-specific lectins. Further studies of the chemical composition and CNS activity of mistletoe are required. The mechanisms of action, target sites, pharmacokinetics, metabolic mechanis

关键词： 《中文核心期刊要目总览》   文献计量学   神经病学   医学杂志   研究人员   专家评审   精神病学   北京大学  

摘要： 《中华神经医学杂志》主编:我们谨此郑重通知:依据文献计量学的原理和方法,经研究人员对相关文献的检索、统计和分析,以及学科专家评审,贵刊《中华神经医学杂志》入编《中文核心期刊要目总览》2017年版(即第8版)之“神经病学与精神病学”类的核心期刊。该书由北京大学出版社出版。

关键词： Achyranthes bidentata polypeptides   Transient ischemic stroke   Microthrombi   Long-term outcome  

摘要： Achyranthes bidentata Bl. (A. bidentata) occupies an important position in traditional Chinese medicine owing to the property of promoting the circulation of blood and removing stasis. Achyranthes bidentata polypeptide k (ABPPk) is one of the active components isolated from A. bidentata. We previously demonstrated that ABPPk has potent neuroprotective effects against neuronal apoptosis both in vitro and in vivo, but the roles and mechanisms of ABPPk on long-term functional recovery after ischemic stroke remain unknown. In the current study, we investigated the neuroprotective effects of ABPPk on filament transient middle cerebral artery occlusion (tMCAO) rats and found that ABPPk reduced the infarct volume and maintained the neuronal integrity in the ischemic penumbra. Moreover, we found that ABPPk might reduce the formation of downstream microthrombus through preventing ischemic-induced oxidative damage of brain endothelial cells and activation of tissue factor (TF), plasminogen activator inhibitor-1 (PAI-1), and NF-kappa B. ABPPk also inhibited polymorphonuclear leukocytes (PMNs) infiltration and matrix metalloproteinase-2/-9 (MMP-2/-9) activation in the ischemic penumbra. Morris water maze, foot fault test, and modified neurological severity score were assessed for a period of 6 weeks following tMCAO. ABPPk improved long-term recognition abilities and neurological outcomes after stroke compared with saline-treated rats. Taken together, these results suggested that ABPPk is beneficial to the improvement of long-term outcomes after transient cerebral ischemia injury and can be used as a potential neuroprotective agent.

关键词： 中华医学会   神经病学   神经科   会议   杂志   出版   合作   学术  

摘要： 中华神经科杂志将与2019年9月份在青岛召开的“中华医学会第22次全国神经病学学术会议”合作出版重点号(正刊,不是增刊)。凡向会议投稿的作者,可把没有发表过的、有关神经科临床或与临床相关的各类稿件(论著,病例报告,综述等)投到中华神经科杂志该期重点号发表。

关键词： 柳叶刀   颅脑创伤   仁济医院   神经病学   长篇论文   神经科学   影响因子   上海交通大学医学院  

摘要： 2月13日,上海交通大学医学院附属仁济医院首席专家、上海市颅脑创伤研究所所长江基尧教授作为唯一通信作者在世界神经科学排名第一《柳叶刀神经病学》杂志(影响因子27.138分)在线发表题为《中国颅脑创伤》的长篇论文。

关键词： 神经病学与神经康复学杂志   证明文件   缩略词   投稿声明  

摘要： 《神经病学与神经康复学杂志》(CN:31-1927/R;ISSN:1672-7061)由上海市卫生和计划生育委员会主管,上海市中西医结合学会、上海交通大学医学院附属仁济医院主办,是国内外公开发行的神经病学与神经康复学领域的专业学术期刊,以神经科、神经康复科和精神科临床医师及相关领域的科研人员及在校师生为主要读者对象.

关键词： 标准化病人   多媒体   神经病学   教学  

摘要： 标准化病人(standardized patients,SP),又称为模拟病人(simulate patients),是指经过标准化、系统化培训后,能准确表现患者的实际临床问题的正常人或患者。SP能够发挥扮演患者、充当评估者和教师3种功能,在医学教学中越来越受到重视,许多学科都已开始应用SP进行教学、培训和考核。而多媒体教学可提供丰富的内容和形式,有助于弥补SP不能提供的教学内容。本文就在脑血管教学中联合应用SP与多媒体教学方法的作用进行讨论。

关键词： 缺血性中风   标化死亡率   发病率   中国   伤残调整生命年   疾病负担   神经病学  

摘要： 2019年3月11日,Lancet神经病学子刊发表的2016全球疾病负担研究一项分析显示,2016年,全球1370万人新发生中风,中国就占了40%,为551万人;全球550万人因中风死亡,中国占1/3,为179万人;全球中风所致伤残调整生命年(DALY)为1.164亿,中国占1/3(3 862万)。2016年,全球有8010万人发生中风,84.4%为缺血性中风。1990-2016年,全球中风死亡率和发病率总体呈下降趋势,年龄标化死亡率和发病率分别降低了36.2%和8.1%。

关键词： 脑卒中   神经病学   医科大学   心内科   义诊   宁夏   健康生活方式   卫生健康  

摘要： 为倡导健康生活方式,提升广大群众对脑卒中防治的关注度,实现脑卒中疾病的早诊早治,近日,由医务处牵头,神经病学中心内科高级卒中中心联合康复医学科开展了“战胜卒中,再立人生”大型义诊活动。宁夏医科大学总医院作为国家卫生健康委批准的高级卒中中心及脑卒中筛查与防治基地,承担着全区脑卒中疾病的检查、治疗、预防工作。本次义诊宣传活动是总医院积极落实《国家卫生健康委疾控局办公厅关于开展2018年“世界卒中日”宣传活动的通知》文件要求的重要举措。