关键词： axial diffusivity   diffusion tensor imaging   fractional anisotropy   longitudinal analysis   ordinal regression analysis   outcome measures   radial diffusivity   traumatic brain injury  

摘要： Traumatic axonal injury (TAI) is the main cause of cognitive and psychological disfunction after a traumatic brain injury (TBI). Diffusion tensor imaging (DTI) is considered a useful technique for indirect assessment of white matter (WM) integrity after a TBI. Scattered WM alterations and its relationship with patient severity have been discovered in normal appearing conventional magnetic resonance imaging (MRI) studies based on DTI sequences. However, there is a lack of large sample studies on the longitudinal changes of DTI metrics to be used to determine the temporal profile after head injury and its association with patient outcome. We performed a prospective observational study in 118 moderate-to-severe TBI patients. The study included clinical outcome assessment based on the Glasgow Outcome Scale Extended (GOSE) and serial DTI studies in the early subacute setting (< 60 days) and 6 and 12 months after injury. Fractional anisotropy (FA) and axial and radial diffusivities (AD and RD, respectively) were measured in the three portions of corpus callosum (genu, body, splenium) at each time-point and compared with normalized values from an age-matched control group. Longitudinal FA analysis and its correlation with patient improvement also was done by non-parametric testing and ordinal regression analysis. Our main results indicated that between all the time-points, dynamic changes in DTI metrics in all three portions of corpus callosum were detected, but TBI patients continued to show significantly lower FA and AD values and higher RD values compared with controls. We also have discovered differences in the change of DTI metrics among different time-points in patient subgroups according with their outcome improvement. In conclusion, even without normalization of DTI metrics in the long-term, knowledge of the temporal profile of change in DTI metrics can provide important information about patients' clinical recovery after TBI.

关键词： Inflammation   Neurological markers   Health-related quality of life   Well-being   Older adults  

摘要： Objectives: Stressful experiences, poor self-rated health, and negative emotional states have been implicated with higher levels of inflammatory markers and lower levels of neurotrophic factors in some healthy adults and clinical populations, but these relationships are unclear in the elderly. This study aimed to identify the associations between systemic inflammatory and neurological markers with well-being and health-related quality of life (HR-QoL) in independently living elderly people. Design: Cross-sectional study. Setting and participants: A total of 268 men and women aged >= 65 years living independently in retirement communities in Melbourne, Australia. Measures: Questionnaires were used to assess HR-QoL [Short Form (SF)-36 version 2] and well-being (Personal Wellbeing Index). Serum inflammatory cytokines [interleukin (IL)-4, IL-6, IL-1 beta, IL-8, IL-10, tumor necrosis factor (TNF)-alpha, and high sensitive C-reactive protein (hs-CRP)] were standardised to Z-scores and used to calculate pro- and anti-inflammatory composite score and an overall composite inflammatory index. Plasma levels of the neurological markers amyloid beta (1-40) and amyloid beta (1-42), brain derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF), were also assessed. Results: No significant associations were found between any inflammatory or neurological marker with HR-OoL or well-being, with the exception that lower perceptions of the HR-QoL vitality subscale were associated with higher levels of hs-CRP [unstandardized beta-coefficient (beta): - 1.50;95% CI: - 2.53, - 0.46;P = 0.004] and Zscores in the pro-inflammatory composite score (beta = - 2.06;95% CI: - 3.49, - 0.62;P = 0.005). Conclusions/implications: In elderly people residing in independent living retirement communities, there was no consistent evidence indicating that circulating inflammatory or neurological markers were associated with the key physical or men

关键词： Rats  

摘要： Injectable hydrogels can perfectly fill defective areas and thereby show promise as therapeutic implants or cell/drug delivery vehicles in traumatic brain injury (TBI) or other tissue repair. In this study, an injectable gelatin hydrogel in situ dual-enzymatically cross-linked by glucose oxidase (GOX) and horseradish peroxidase (HRP) was synthesized and optimized, and the therapeutic effect of this hydrogel encapsulated with bone mesenchymal stem cells (BMSC) for TBI rats was investigated. By changing the GOX content, we found that this hydrogel cross-linked by 0.1 U mL(-1) GOX possesses better cytocompatibility than that with a higher GOX content, and minimized immune response in vivo. More importantly, this hydrogel loaded with BMSC could significantly accelerate the healing process of a damaged region, facilitate the survival and proliferation of endogenous nerve cells probably by nutrition supply and apoptosis suppression, and consequently promote the neurological function recovery of the TBI rat model. All these findings highlight that this injectable and BMSC-laden gelatin hydrogel has enormous potential for TBI therapy and other tissue regeneration strategies.

关键词： HaNDL   Pseudomigraine with pleocytosis   Acute confusional syndrome   Cerebral vasomotor changes   Transcranial Doppler   Cannabis and cocaine use   HaNDL   Pseudomigraña con pleocitosis   Síndrome confusional   Vasoespasmo   Doppler transcraneal   Consumo de cannabis y cocaína  

摘要： AbstractIntroductionHaNDL syndrome (transient headache and neurological deficits with cerebrospinal fluid lymphocytosis) is characterised by one or more episodes of headache and transient neurological deficits associated with cerebrospinal fluid lymphocytosis. To date, few cases of HaNDL manifesting with confusional symptoms have been described. Likewise, very few patients with HaNDL and confusional symptoms have been evaluated with transcranial Doppler ultrasound (TCD). TCD data from patients with focal involvement reveal changes consistent with vasomotor alterations. DevelopmentWe present the case of a 42-year-old man who experienced headache and confusional symptoms and displayed pleocytosis, diffuse slow activity on EEG, increased blood flow velocity in both middle cerebral arteries on TCD, and single-photon emission computed tomography (SPECT) findings suggestive of diffuse involvement, especially in the left hemisphere. ConclusionsTo our knowledge, this is the first description of a patient with HaNDL, confusional symptoms, diffuse slow activity on EEG, and increased blood flow velocity in TCD. Our findings suggest a relationship between cerebral vasomotor changes and the pathophysiology of HaNDL. TCD may be a useful tool for early diagnosis of HaNDL.

关键词： 一稿两投   临床神经病学   杂志   文稿  

摘要： 为维护本刊声誉和广大读者的利益,现对一稿两投和一稿两用问题的处理声明如下:(1)本声明中所涉及的文稿均指原始研究的报告或尽管2篇文稿在文字的表达和讨论的叙述上可能存在某些不同之处,但这些文稿的主要数据和图表是相同的。

关键词： 临床电生理   神经电生理   肌电图   中国   中华人民共和国   神经病学  

摘要： 光阴似箭,岁月如梭,在中华人民共和国70岁生日即将到来之际,作为神经病学和临床电生理-肌电图的晚辈,再次心怀感恩地梳理中国临床神经电生理-肌电图的发展过程。感谢前辈为中国临床神经电生理的发展做出的不可磨灭的贡献。

关键词： 《中国神经免疫学和神经病学杂志》   统计源期刊   稿约   中国免疫学会   中国学术期刊   科技论文   专业期刊   卫生健康  

摘要： 《中国神经免疫学和神经病学杂志》(双月刊,ISSN 1006-2963,CN 11-3552/R)是一本报道我国神经病学,尤其是神经免疫学领域研究新成果、新进展、新动态的学术性专业期刊,由国家卫生健康委员会主管,北京医院、中国免疫学会神经免疫分会主办,国内外公开发行(国内邮发代号:82-718;国外:BM1302)。本刊属中国科技核心期刊、北大图书馆收录期刊(2017版)、中国科技论文统计源期刊、中国学术期刊综合评价数据库来源期刊等。

关键词： 《中文核心期刊要目总览》   文献计量学   神经病学   医学杂志   研究人员   专家评审   精神病学  

摘要： 《中华神经医学杂志》主编:我们谨此郑重通知:依据文献计量学的原理和方法,经研究人员对相关文献的检索、统计和分析,以及学科专家评审,贵刊《中华神经医学杂志》入编《中文核心期刊要目总览》2017年版(即第8版)之“神经病学与精神病学”类的核心期刊。