摘要： Introduction Central nervous system involvement is one of the most devastating aspects of *** The aims of this review are to document the range of neurological complications of sickle cell *** This is a prospective Hospital based, cross-sectional study. One hundred Sudanese patients with Sickle cell anemia were included in the study during the period from March to July *** The most common age group affected was below 20 years, Male to female ratio was almost equal, irritability & headache were the most common symptoms 41%, 40% respectively. Numbness was observed in 25%, hemiplegia in 24%, seizure in 19%, recurrence of hemiplegia occurred in 8%, gait was found to be spastic in 14%, limping gait (due to non neurological causes) in 7%, while inability to walk in 6% and cerebeller manifestation in 2%.Conclusion The study revealed high incidence of irritability and headache followed by numbness then hemiplegia. Hemiplegia is usually ischemic in children and hemorrhagic in adults. Silent brain infarcts occur in 17% of patients. Convulsions occur as an isolated event but frequently associated with stroke.