关键词： outcome   quality of life   severe trauma   traumatic brain injury  

摘要： After traumatic brain injury (TBI), the relationship between age and outcome at 1 year, including quality of life, has been poorly explored. The aim of our study was to describe this relationship in a cohort of TBI patients in a regional trauma system. Consecutive TBI patients with severe lesions on initial brain computed tomography (CT) scan were included from July 2014 to July 2016 in two French level-1 trauma centers. The primary outcome was the mortality at 1 year and secondary outcomes were Glasgow Outcome Scale-Extended (GOS-E) and quality of life using the Short Form Health Survey (SF-12). The relationship between age and outcome was modeled using the generalized linear model (GLM). Within the study period, 427 patients with TBI and type 3 Abbreviated Injury Scale (AIS) lesions were included. Finally, 380 patients were assessed for mortality. Ninety-six (25%) patients died at 1 year. The detailed neurological status was available for 317 patients. One year after the trauma, 141 (44%) patients had a favorable outcome (GOS-E 7 and 8), whereas 53 (17%) patients had a moderate disability (GOS-E 5-6), 27 (9%) patients had a severe disability or were in a vegetative state (GOS-E 2-4), and 96 (30%) patients had died (GOS-E 1). After 70 years of age, a dramatic increase in the odds of death and poor neurological outcome was found using GLM. No difference according to age was found for the quality of life. After TBI, the mortality at 1 year dramatically increased with age after 70 years. For elderly survivors, impairment of quality of life was not different from younger patients.

关键词： mass spectrometry imaging   mouse brain   proteomics   metabolomics   glycomics   lipidomics  

摘要： Mass spectrometry imaging (MSI) has emerged as a powerful tool for multiomics study in neurology. MSI combines the multichannel (m/z) measurement capability of mass spectrometers with a surface sampling process that allows for rapid probing and mapping of the characterized intact proteins, proteolytic digested peptides, released glycans, phospholipids, glycolipids, and small metabolites in brain tissues. The present review is focused on the application of MSI to the study of proteomics, glycomics, peptidomics, metabolomics, and lipidomics in mouse brain tissues.

关键词： 中华医学会   认知障碍   神经病学   痴呆   学分   治疗方法   学术组织   临床医师  

摘要： 随着人口的老龄化进程加快,全世界痴呆发病率逐年上升,不仅危害着老年人的身心健康和生活质量,同时给家庭和社会带来沉重的负担,已成为家庭、社会和政府面临的严峻问题.然而痴呆治疗方法有限,目前的治疗方法尚不能遏制痴呆发病率的快速增长.早在20世纪末,美国、英国等发达国家开始成立学术组织,旨在于推动国际痴呆的研究,提高早期痴呆防治水平,有效降低发病率.我国中华医学会神经病学分会痴呆学术组织起步较晚,直到2006年才成立了痴呆与认知障碍学组.学组的成立顺应了医学发展的潮流,极大地推动了我国痴呆和认知障碍专业的临床和基础研究多学科交叉,使痴呆研究得到了广泛的关注,吸引了大批的临床医师和研究者投入其中,对推动我国神经病学和痴呆事业的发展具有重要的意义。

关键词： 神经病学   高峰论坛  

摘要： 由国家核心期刊《中国神经精神疾病杂志》编辑部主办的国家级继续教育项目“第二十二届国际神经病学中山高峰论坛?2019”将于2019年11月22-24日在广州花都皇冠假日酒店举行。本次大会将邀请国内外著名专家进行主题演讲,主要内容有脑血管病、脑小血管病、脑血管介入治疗、神经遗传病、神经系统退行变性疾病、神经科学基础研究、神经电生理、中枢神经系统感染、疑难病例讨论与论文交流等。

关键词： 《中文核心期刊要目总览》   文献计量学   神经病学   医学杂志   研究人员   专家评审   精神病学  

摘要： 《中华神经医学杂志》主编:我们谨此郑重通知:依据文献计量学的原理和方法,经研究人员对相关文献的检索、统计和分析,以及学科专家评审,贵刊《中华神经医学杂志》入编《中文核心期刊要目总览》2017年版(即第8版)之“神经病学与精神病学”类的核心期刊。

关键词： 脑血管病   神经病学   学科建设  

摘要： 首都医科大学附属北京天坛医院从建立神经内科,搭建神经病学学科建设平台的过程中,以脑血管病为中心,全面发展神经病学各个亚专业,创建了包括多个神经科学相关临床专业、临床和基础研究、统计学在内的神经病学中心。本文介绍了天坛医院瞄准国际前沿脉动,创新发展各个学科,注重青年人才培养,在基础和临床研究领域做出了国际一流的突出成绩,改写国际指南,使得神经病学科全面发展,其卓有成效的发展模式为全国神经病学中心建设和人才培养提供了典范和经验。

关键词： neurological disorders   epigenetics   ART  

摘要： About 1-4% of children are currently generated by Assisted Reproductive Technologies (ART) in developed countries. These babies show only a slightly increased risk of neonatal malformations. However, follow-up studies have suggested a higher susceptibility to multifactorial, adult onset disorders like obesity, diabetes and cardiovascular diseases in ART offspring. It has been suggested that these conditions could be the consequence of epigenetic, alterations, due to artificial manipulations of gametes and embryos potentially able to alter epigenetic stability during zygote reprogramming. In the last years, epigenetic alterations have been invoked as a possible cause of increased risk of neurological disorders, but at present the link between epigenetic modifications and long-term effects in terms of neurological diseases in ART children remains unclear, due to the short follow up limiting retrospective studies. In this review, we summarize the current knowledge about neurological disorders promoted by epigenetics alterations in ART. Based on data currently available, it is possible to conclude that little, if any, evidence of an increased risk of neurological disorders in ART conceived children is provided. Most important, the large majority of reports appears to be limited to epidemiological studies, not providing any experimental evidence about epigenetic modifications responsible for an increased risk.

关键词： 形成性评价   终结性评价   神经病学   临床实习  

摘要： 目的:探讨形成性评价在神经病学临床实习教学中的作用,为提高神经病学临床实习效果提供理论依据。方法:将武汉市某医院2014级神经病学临床医学专业90名本科实习生分为对照组(终结性评价)和实验组(形成性评价)进行研究。结果:实验组学生总成绩明显高于对照组学生,两组差异有统计学意义。实验组学生对形成性评价的教学效果高度认同。结论:在神经病学临床实习中引入形成性评价教学方式,能够显著提高学生的实习效果和教学质量,值得应用和推广。

关键词： 阿尔茨海默病   高等教育   神经病学   教育水平   痴呆症  

摘要： 2019-02-06在线发表在《神经病学杂志》(Journal of Neurology)上新的研究表明,寻求高等教育有很多充分的理由,但是避免阿尔茨海默病可能不是其中之一。该研究发现,一个人的教育水平与记忆和思维(认知)问题的发生或痴呆症发展的速度无关。

关键词： hindlimb unloading   chronic low-dose irradiation   brain   transcriptome  

摘要： Spaceflight poses many challenges for humans. Ground-based analogs typically focus on single parameters of spaceflight and their associated acute effects. This study assesses the long-term transcriptional effects following single and combination spaceflight analog conditions using the mouse model: simulated microgravity via hindlimb unloading (HLU) and/or low-dose gamma -ray irradiation (LDR) for 21 days, followed by 4 months of readaptation. Changes in gene expression and epigenetic modifications in brain samples during readaptation were analyzed by whole transcriptome shotgun sequencing (RNA-seq) and reduced representation bisulfite sequencing (RRBS). The results showed minimal gene expression and cytosine methylation alterations at 4 months readaptation within single treatment conditions of HLU or LDR. In contrast, following combined HLU+LDR, gene expression and promoter methylation analyses showed multiple altered pathways involved in neurogenesis and neuroplasticity, the regulation of neuropeptides, and cellular signaling. In brief, neurological readaptation following combined chronic LDR and HLU is a dynamic process that involves pathways that regulate neuronal function and structure and may lead to late onset neurological sequelae.