摘要： Background Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune demyelinating disorder of the central nervous system that was previously thought to be a subtype of multiple sclerosis (MS). We describe radiological characteristics of a case series of NMOSD patients from the largest tertiary neurology centre in *** This is a case series study of NMOSD patients who were seen at the Multiple Sclerosis clinic, Ibn Sina Hospital from January 2017 to January 2019. We describe their magnetic resonance imaging (MRI) *** Our study identified 32 patients who fulfilled the 2015 international NMOSD diagnostic criteria. Twenty-six females and 6 males were identified of whom 22 patients tested positive for AQP4 antibodies in the serum while 10 were seronegative. The mean age was 35.4 and mean age at onset was 28.5 years with an average disease duration of 7 years. There was a strong female predominance with a ratio of 4.3:1. We identified MRI features of the cohort and compared it with those reported in other worldwide *** This is the first study from Kuwait describing the radiological characteristics of NMOSD. We highlighted the similarities and differences of our cohort from other worldwide cohorts reported in the literature.